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141.
Maret S Franken P Dauvilliers Y Ghyselinck NB Chambon P Tafti M 《Science (New York, N.Y.)》2005,310(5745):111-113
Delta oscillations, characteristic of the electroencephalogram (EEG) of slow wave sleep, estimate sleep depth and need and are thought to be closely linked to the recovery function of sleep. The cellular mechanisms underlying the generation of delta waves at the cortical and thalamic levels are well documented, but the molecular regulatory mechanisms remain elusive. Here we demonstrate in the mouse that the gene encoding the retinoic acid receptor beta determines the contribution of delta oscillations to the sleep EEG. Thus, retinoic acid signaling, which is involved in the patterning of the brain and dopaminergic pathways, regulates cortical synchrony in the adult. 相似文献
142.
Mohaddeseh A. Tabari Mohammad Reza Youssefi Seyed Mehdi Hosseinifard Ali Akbar Moghaddamnia Sohrab Kazemi NadAli Yousefi Sadati Azadeh Jalali Mothahari Mario Giorgi 《Journal of veterinary pharmacology and therapeutics》2020,43(3):276-281
The pharmacokinetic parameters of levamisole were determined in the Caspian salmon after intramuscular (IM), oral by gavage, and oral by feed administrations. Eighty-one healthy fish in three different groups received levamisole at the dose of 25 mg/fish by each route. Blood samples were collected at time points of 0, 0.5, 1, 2, 4, 6, 12, 14, and 24 hr after administrations. Plasma levamisole concentrations were measured by a validated high-performance liquid chromatography (HPLC) assay and were analyzed using a noncompartmental approach. The mean terminal half-life was 4.56, 3.95, and 2.91 hr for IM, gavage and feed routes, respectively. The peak plasma concentration for IM, gavage, and feed routes of levamisole were 35.53, 4.63, and 8.36 µg/ml, respectively, at the time of 0.25 for IM, and 1 hr for gavage and feed. The relative bioavailability for gavage and feed routes was 54.80 and 69.30. The similar bioavailability for gavage and feed might be indicative of similar efficacy for these routes of administrations. Further studies are warranted to evaluate the absolute oral bioavailability and the effective dose in Caspian salmon. 相似文献
143.
Jiriaei Fatemeh Kazemi-Bonchenari Mehdi Moradi Mohammad Hossein Mirmohammadi Davood 《Tropical animal health and production》2020,52(2):829-837
Tropical Animal Health and Production - The effects of feeding corn steep liquor (CSL; 420 g/kg crude protein, DM basis) along with different cereal grains on performance, digestibility,... 相似文献
144.
Sadeghi Seyed Abu Taleb Rokouei Mohammad Valleh Mehdi Vafaye Abbasi Mokhtar Ali Faraji-Arough Hadi 《Tropical animal health and production》2020,52(2):733-742
Tropical Animal Health and Production - Non-additive genetic effects are important to increase the accuracy of estimating genetic parameters for growth traits. The aim of this study was to estimate... 相似文献
145.
Sotelo E Gutierrez-Guzmán AV Del Amo J Llorente F El-Harrak M Pérez-Ramírez E Blanco JM Höfle U Jiménez-Clavero MA 《Veterinary research》2011,42(1):11
ABSTRACT: West Nile virus (WNV) is an emerging zoonotic pathogen whose geographic spread and incidence in humans, horses and birds has increased significantly in recent years. WNV has long been considered a mild pathogen causing self-limiting outbreaks. This notion has changed as WNV is causing large epidemics with a high impact on human and animal health. This has been particularly noteworthy since its introduction into North America in 1999. There, native bird species have been shown to be highly susceptible to WNV infection and disease with high mortalities. For this reason, the effect of WNV infection in North American bird species has been thoroughly studied by means of experimental inoculations in controlled trials. To a lesser extent, European wild birds have been shown to be affected clinically by WNV infection. Yet experimental studies on European wild bird species are lacking. The red-legged partridge (Alectoris rufa) is a gallinaceous bird indigenous to the Iberian Peninsula, widely distributed in South Western Europe. It plays a key role in the Mediterranean ecosystem and constitutes an economically important game species. As such it is raised intensively in outdoor facilities. In this work, red-legged partridges were experimentally infected with two recent WNV isolates from the Western Mediterranean area: Morocco/2003 and Spain/2007. All inoculated birds became viremic and showed clinical disease, with mortality rates of 70% and 30%, respectively. These results show that Western Mediterranean WNV variants can be pathogenic for some European bird species, such as the red-legged partridge. 相似文献
146.
147.
Namazi F Namavari MM Rahimi E Lotfi M Tahamtan Y 《Veterinary research communications》2011,35(7):425-431
The Apicomplexan parasite Besnoitia caprae infects wild and domestic goats. Knowledge on Besnoitia caprae specially an optimized animal model is sparse. Experimental infections with tachyzoites of BC-Pars obtained from BALB/c mice
were conducted in outbred mice to determine the infectivity and LD50 of Besnoitia caprae. Six groups of five mice were intraperitoneally infected with 12.5 × 103, 25 × 103, 5 × 104, 1 × 105 and 2 × 105 tachyzoites and a control inoculum of DMEM, respectively. Although morbidity and mortality were observed in all groups, two
mice in the 12.5 × 103 group showed alopecia and skin lesions on 60 days post-infection (DPI). Histopathological and molecular examination of skins
confirmed B. caprae infection. The LD50 was calculated as 25 × 103.2 tachyzoites per mouse. The results indicate that outbred BALB/c mice can be used as a suitable model of besnoitiosis and
to screen candidate treatments and to test the efficacy of vaccines for besnoitiosis. 相似文献
148.
Lamien CE Le Goff C Silber R Wallace DB Gulyaz V Tuppurainen E Madani H Caufour P Adam T El Harrak M Luckins AG Albina E Diallo A 《Veterinary microbiology》2011,149(1-2):30-39
Sheep poxvirus (SPPV), Goat poxvirus (GTPV) and Lumpy skin disease virus (LSDV) are Capripoxviruses (CaPVs) responsible for causing severe poxvirus disease in sheep, goats and cattle, respectively. Serological differentiation of CaPVs is not possible and strain identification has relied on the implicitly accepted hypothesis that the viruses show well defined host specificity. However, it is now known that cross infections can occur and authentication of identity based on the host animal species from which the strain was first isolated, is not valid and should be replaced with molecular techniques to allow unequivocal strain differentiation. To identify a diagnostic target for strain genotyping, the CaPV homologue of the Vaccinia virus E4L gene which encodes the 30 kDa DNA-dependent RNA polymerase subunit, RPO30 was analyzed. Forty-six isolates from different hosts and geographical origins were included. Most CaPVs fit into one of the three different groups according to their host origins: the SPPV, the GTPV and the LSDV group. A unique 21-nucleotide deletion was found in all SPPV isolates which was exploited to develop a RPO30-based classical PCR test to differentiate SPPV from GTPV that will allow rapid differential diagnosis of disease during CaPV outbreaks in small ruminants. 相似文献
149.
Shirani D Nassiri SM Aldavood SJ Seddigh HS Fathi E 《The Canadian veterinary journal. La revue veterinaire canadienne》2011,52(4):389-393
Dysplastic features of erythroid and megakaryocytic lineages were observed in a cat with acute erythroid leukemia. We demonstrated that flow cytometry analysis of the expression of glycophorin A and CD71 by neoplastic cells can be helpful in the diagnosis of this type of feline leukemia. 相似文献
150.
Density and resin content are two factors that have a signifi- cant effect on the production cost of wood composite. However, particle size affects resin content and density, which suggests that the interaction of these three factors can be manipulated to reduce the board density and resin content of particleboard without adversely influencing its mechani- cal properties. Some mathematical functional forms based on resin con- tent, board density and slenderness ratio were regressed and an appropri- ate form was chosen. According to analysis of the results using SHA- ZAM 9 software, the exponential function best fit the experimental data. Finally, "indifference curves" of mechanical properties were illustrated and analyzed. The results indicated that negative effects of density or resin content reduction on mechanical properties could be compensated for by controlling particles’ slenderness ratio. Interestingly, increases in slenderness ratio compensated for the negative effects of decreases in resin content or board density on module of rupture (MOR) and module of elasticity (MOE). Moreover, this "compensation ratio" intensified as resin content or density decreased and/or as the MOR or MOE increased. On the other hand, reduction in slenderness ratio indicated a comple- mentary effect on reducing internal bond (IB) strength, a result of de- creases in resin content or density. Moreover, this "complementary ratio" was intensified as resin content or density decreased and/or as IB strength increased. 相似文献