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541.
Preliminary studies showed that lufenuron inhibits chitin synthesis, a dermatophyte cell wall constituent, and may be effective in the treatment of dermatophytosis. Our purpose was to evaluate the efficacy of lufenuron in the treatment of feline dermatophytosis. Forty-six cats (Persians and mixed-breed cats from 1-month to 4-years old) naturally infected with Microsporum canis were included in this study. Fifteen cats were treated isolated in cages in the veterinary hospital and 31 were treated in their home environment (some with access to the outdoors). Dermatophyte skin lesions were seen in 29 animals while 17 other cats were asymptomatic carriers. Wood's lamp, direct microscopic examination of hairs, fungal culture and skin biopsies were used for the diagnosis. Affected cats and all in-contact animals received lufenuron at a dose of 120 mg/kg every 21 days for four treatments. Of the 29 symptomatic cats treated with lufenuron, 70% recovered within 21 days and 28% within 42 days of initiation of therapy. One cat had only partial recovery and another was euthanized. Negative fungal culture was recorded only after the fourth dose of lufenuron in 98% of affected cats and 100% of asymptomatic carriers. There was no difference in clinical response to lufenuron between the cats treated in their home environment and those treated in the veterinary hospital. Side effects were not observed, thus the drug proved to be safe and effective for the treatment of dermatophytosis.
Funding: Novartis. 相似文献
Funding: Novartis. 相似文献
542.
利用雷诺平均Navier-Stokes方程,采用标准k-ε双方程湍流模型,对具有代表性的FFA-W系列翼型的气动性能进行了模拟计算,结果表明该系列翼型适合于在风能热利用系统中应用。探讨了台阶翼型在系统中应用的可行性。分析了系统气动扭矩和负载匹配的关系,对各种热能转换设备的特性进行了比较,结果表明,选用油压泵作为负载,薄壁阻尼孔作为热转换设备,可以使系统始终在最佳工况点运行。结合分析,给出了系统的主要选型结果。 相似文献
543.
van Breugel M Hirono M Andreeva A Yanagisawa HA Yamaguchi S Nakazawa Y Morgner N Petrovich M Ebong IO Robinson CV Johnson CM Veprintsev D Zuber B 《Science (New York, N.Y.)》2011,331(6021):1196-1199
Centrioles are cylindrical, ninefold symmetrical structures with peripheral triplet microtubules strictly required to template cilia and flagella. The highly conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. We determined the x-ray structure of the amino-terminal domain of SAS-6 from zebrafish, and we show that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers. Point mutations are consistent with the notion that centriole formation in vivo depends on the interactions that define the self-assemblies observed here. Thus, these interactions are probably essential to the structural organization of cartwheel centers. 相似文献
544.
C. Kiribuchi-Otobe T. Nagamine T. Yanagisawa M. Ohnishi I. Yamaguchi 《Cereal Chemistry》1997,74(1):72-74
In our wheat breeding program to introduce the low amylose character of Tanikei A6099 to elite lines, five waxy lines were unexpectedly obtained from 249 doubled haploid lines of the F1 hybrid of Saikai 168 × Tanikei A6099. The amylose content of all the waxy lines was <1% and the blue value was <0.1. Starch granule-bound proteins were extracted and subjected to modified sodium dodecyl sulfate polyacrylamide gel electrophoresis. The waxy lines lacked the Wx protein. Starch paste viscosity measurements gave pasting profiles of waxy wheat starch that were quite different from those of nonwaxy wheats but similar to those of waxy maize. However, the peak viscosity of waxy wheats was much higher than that of the waxy maize. 相似文献