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61.
The prognosis of canine soft-tissue sarcomas (STS) has traditionally been based on histologic grading. We have recently demonstrated the prognostic value of cellular proliferation markers in canine STS. Another method of predicting the behavior of neoplasms is intratumoral microvessel density (IMD), which is a measure of tumor angiogenesis. The prognostic significance of IMD has been documented in many human neoplasms and in a limited number of canine and feline neoplasms. To evaluate the prognostic value of IMD in canine STS, we studied 57 STS and compared IMD with histologic features, histologic grade, cellular proliferation, metastatic propensity, and survival. Using immunohistochemistry, the STS were labeled with anti-factor VIII-related antigen (FVIII-RA) and anti-CD31 antibodies to determine 3 IMD parameters: mean microvessel density, high microvessel density, and microvessel area. Using FVIII-RA and CD31, increasing IMD was statistically associated with increasing histologic grade, necrosis scores, and mitotic scores. Higher FVIII-RA IMD values were significantly associated with higher median argyrophilic nucleolar organizing region (AgNOR) values (as previously investigated) and increased metastatic propensity. Fibrosarcomas appear to be the least vascularized of STS. There is no correlation between IMD and survival. Our results indicate that IMD is of prognostic value for histologic grade, histologic features, cellular proliferation (based on AgNOR), and metastatic propensity of canine STS, specifically when using FVIII-RA as the endothelial marker. Assessing histologic grading, cellular proliferation, and IMD of canine STS at the time of diagnosis could therefore provide better prognostic information for the veterinary clinician.  相似文献   
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冬季日光温室的保温措施及对天气性灾害的预防对策   总被引:1,自引:0,他引:1  
高效节能日光温室以太阳能为主要能源 ,不加温或临时加温就能进行果菜类生产 ,但近几年发展的温室偏高偏宽 ,保温措施又跟不上 ,结果在1 999年冬至 2 0 0 0年春雪多、严寒的条件下 ,不少温室出现了 2℃以下低温 ,甚至冻害 ,使果菜类生产受到很大影响 ,造成了很大的损失。对此 ,我站经过试验和调研 ,提出如下的保温措施及对天气灾害性的对策 ,使果菜类冬季能在日光温室得以正常生长 ,进一步提高冬季蔬菜生产的经济效益和社会效益 ,保证我市保护地蔬菜生产持续发展。1 温室结构与保温的关系沈阳市地处北纬 41°以北 ,冬至太阳高度角低 ,中午 …  相似文献   
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An assessment was made of the growth-inhibiting, bactericidal, and urease inhibitory activities of paeonol (PA), benzoic acid (BA), methyl gallate (MG), and 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose (PGG) identified in Paeonia lactiflora root, structurally related compounds, and four antibiotics toward three reference strains and four clinical isolates of Helicobacter pylori using broth dilution bioassay and Western blot. BA and PA showed strong bactericidal effect at pH 4, while MG and PGG were effective at pH 7. These constituents exhibited strong growth-inhibiting and bactericidal activity toward the five strains resistant to amoxicillin (minimal inhibitory concentration (MIC) 12.5 mg/L), clarithromycin (64 mg/L), metronidazole (64 mg/L), or tetracycline (15 mg/L), indicating that these constituents and the antibiotics do not share a common mode of action. Structural characteristics, such as types of functional groups and carbon skeleton, and hydrophobicity appear to play a role in determining the anti- H. pylori activity. H. pylori urease inhibitory activity of PGG was comparable to that of acetohydroxamic acid, while MG was less potent at inhibiting urease than thiourea. The UreB band disappeared at 250 mg/L PGG on Western blot, while the UreA bands were faintly visible at 1000 mg/L PGG. These constituents showed no significant cytotoxicity. Global efforts to reduce the level of antibiotics justify further studies on P. lactiflora root-derived materials containing MG, PA, and PGG as potential antibacterial products or lead molecules for the prevention or eradication from humans from diseases caused by H. pylori .  相似文献   
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自1960年来,已建造了数千幢部分或全部漏缝地板的肥育猪舍,但每头肥育猪的空间有限,通常为O.54~O.64平方米.在西欧进行的比较试验证明,当采用部分漏缝地板,且每头猪有o.70平方米空间时,技术效益较好.而如果猪能在箱型矮栏里休息,效果就更佳好动的肥育猪一般不怕贼风或低温的影响.试验表明,把饲喂和排粪区与躺卧区分开,是很有利的.躺卧区三面能够关闭,并可用顶盖覆盖,以创造  相似文献   
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Gases are transparent and the piping layout in anesthesia machines is not obvious, making it hard to understand anesthesia machine function, potential failure modes, and recovery from faults. We experimented with an approach that simplified the layout of the anesthesia machine piping by removing extraneous details and making gases not only visible, but also color-coded. More than 15 anesthesia machine controls were represented by icons that a user can adjust by clicking on the icon with a pointing device and subsequently observing the effect of his/her intervention on anesthesia machine function in real time. We simulated two anesthesia machine failures and also supported non-English languages and non-US gas color codes. Further, we initiated an experiment in Web philanthropy by deliberately choosing to make the educational module accessible without charge and selected the Web as the preferred medium for dissemination of the Virtual Anesthesia Machine (VAM) viewable at http://www.anest.ufl.edu/vam . Originally designed for use in human anesthesiology, a significant percentage (about 30%) of the 54 000 international visitors, as tracked by an independent third-party Web traffic monitoring service, for the period 9/00–5/02, were from the veterinary field. VAM is being used as part of the curriculum in veterinary programs in the US and overseas and has been well received by the global anesthesia community (human and veterinary).  相似文献   
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传统的营销模式已经不能满足企业发展的需求,建立新的兽药产品区域市场营销体系是兽药企业的选择。  相似文献   
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