排序方式: 共有73条查询结果,搜索用时 15 毫秒
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van Herten J 《Tijdschrift voor diergeneeskunde》2006,131(4):140-142
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Chiara Valtolina DVM MRCVS Joris H Robben DVM PhD Diplomate ECVIM-CA Joost Uilenreef DVM Diplomate ECVAA Joanna C Murrell BVSc PhD Diplomate ECVAA John Aspegrén† MSc Brett C McKusick† DVM MS PhD & Ludo J Hellebrekers DVM PhD Diplomate ECVAA 《Veterinary anaesthesia and analgesia》2009,36(4):369-383
ObjectiveTo compare postoperative analgesia provided by a constant rate infusion (CRI) of dexmedetomidine (DMED) to that of a well-established positive control [morphine (MOR)] in critically ill dogs. The sedative, cardiorespiratory effects and clinical safety of a 24-hour DMED CRI were also evaluated.Study designProspective, randomised, blinded, positive-controlled parallel-group clinical study.AnimalsForty hospitalised, client-owned dogs requiring post-operative pain management after invasive surgery.MethodsAfter surgery, a loading dose of either DMED (25 μg m?2) or MOR (2500 μg m?2) followed by a 24-hour CRI of DMED (25 μg m?2 hour?1) or MOR (2500 μg m?2 hour?1) was administered. Pain was measured using the Short Form of the Glasgow Composite Measure Pain Scale, sedation and physiological variables were scored at regular intervals. Animals considered to be painful received rescue analgesia and were allocated to a post-rescue protocol; animals which were unresponsive to rescue analgesia were removed from the study. Data were analysed with anova, two-sample t-tests or Chi-square tests. Time to intervention was analysed with Kaplan–Meier methodology.ResultsForty dogs were enrolled. Twenty dogs (9 DMED and 11 MOR) did not require rescue analgesia. Eleven DMED and eight MOR dogs were allocated to the post-rescue protocol and seven of these removed from the study. Significant differences in pain scores between groups were not observed during the first 12 hours, however, DMED dogs were less (p = 0.009) painful during the last 12 hours. Sedation score over the entire 24-hour study was not significantly different between groups.Conclusion / Clinical RelevanceDexmedetomidine CRI was equally effective as MOR CRI at providing postoperative analgesia and no clinically significant adverse reactions were noted. This study shows the potential of DMED to contribute to a balanced postoperative analgesia regimen in dogs. 相似文献
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Veerle Lamote Joost Baert Isabel Roldán-Ruiz Marc De Loose Erik Van Bockstaele 《Euphytica》2002,123(2):159-164
Several genotypes of Lolium perenne (2n = 2x = 14) were screenedfor the production of 2n eggs. In each cross a diploid genotype, used asfemale parent, was pollinated with a tetraploid genotype. All interploidycrosses were made in isolation cages. Flow cytometrical analysis of theprogeny of 154 diploid plants revealed 28 tetraploid descendants. Theseoffspring plants were harvested on 15 different diploid mother plants.Amplified Fragment Length Polymorphism (AFLP) markers were used tocheck the parenthood of these tetraploids. Two seedlings died, theremaining plants could, after AFLP fingerprinting, be identified as meiotictetraploids. The results obtained allowed to conclude that the tetraploidprogeny plants harvested on 15 diploid mother plants were the result ofthe fertilisation of an unreduced egg by a reduced pollen grain of thetetraploid plant. 相似文献
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Thomas C. Ponsioen Huib Hengsdijk Joost Wolf Martin K. van Ittersum Reimund P. Rötter Tran Thuc Son Alice G. Laborte 《Agricultural Systems》2006
Agricultural research in East and Southeast Asia is increasingly challenged by the search for land-use options that best match multiple development objectives of rural societies (e.g., increased income, food security, and reduced environmental pollution). In order to support the identification of sustainable land-use options and to support decision making with respect to land use, a tool was developed for quantifying inputs and outputs of cropping systems at the field level. TechnoGIN, the tool described in this paper, integrates systems analytical and expert knowledge and different types of agronomic data enabling the assessment of inputs and outputs of a broad range of cropping systems and the evaluation of their resource use efficiencies. By using methods of spatial aggregation in combination with linear programming, results can also be used to explore trade-offs in resource-use efficiencies at higher levels such as the farm household, municipality and province. New features in TechnoGIN compared with similar tools include the annual rotation of up to three crops, the distinction between aerobic and anaerobic growing conditions of crops, and the procedure for estimating crop nutrient uptake. TechnoGIN is illustrated with results from the Tam Duong district in North Vietnam. The design of TechnoGIN enables easy access to its data, parameters and assumptions, and rapid generation and evaluation of input–output relationships of cropping systems in order to add new information and to improve data. TechnoGIN raises awareness about the assumptions incorporated and thus supports data collection and setting of the research agenda with respect to agro-ecological processes for which knowledge is incomplete, and is relevant for showing trade-offs between production, economic and environmental impacts of different land-use systems. 相似文献
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The paper assesses the impact of the removal of operating subsidies to the Philippine National Irrigation Administration on the management performance of a small canal irrigation system in Southern Luzon. It shows that in this case the creation of financial autonomy of the agency did not fully engender the often assumed positive effects regarding both accountability relationships and irrigation management performance. The conclusions specify a number of issues related to the theory of financial autonomy which require further study. 相似文献