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Yinghua Li Seung-Beom Cha Youngil Park Bo-Ho Gong In-Yeong Jeong Hak-Soo Kim Min-Soo Kang Young-Suk Kim Chang Hoon Han Hyun-Kul Lee Si-Whan Song Chae-Gyoo Park Boo-Hyon Kang 《Journal of toxicologic pathology》2022,35(1):45
Platycodi radix is widely used in traditional herbal medicine for the treatment of bronchitis, asthma, pulmonary tuberculosis, hypertension, hyperlipidemia, and diabetes. This study aimed to investigate cell proliferation (Ki-67) and apoptosis (Caspase-3) potential in squamous cell hyperplasia of the stomach induced by a Platycodi radix water extract in a subchronic toxicity study. One hundred formalin-fixed, paraffin-embedded stomach tissues of rats treated with Platycodi radix at doses of 0, 500, 1,000, and 3,000 mg/kg body weight/day were used for the analysis. They were conventionally stained using hematoxylin and eosin (H&E) and immunohistochemically (IHC) stained using caspase-3 and Ki-67 antibodies. The incidence of squamous cell hyperplasia was significantly increased in the 3,000 mg/kg b.w./day treatment group in both sexes (p<0.01). However, the hyperplastic change was completely repaired after 4 weeks of recovery period. Ki-67 expression was similar in all groups, with no statistically significant differences among the groups. Caspase-3 expression was significantly increased in both sexes in the 3,000 mg/kg b.w./day treatment group (p<0.01), compared with the vehicle control groups, and then reduced to normal levels in the recovery groups in both sexes. In conclusion, this study showed that squamous cell hyperplasia induced by the Platycodi radix water extract in the limiting ridge of the stomach is not considered to be abnormal proliferative change; as a result, squamous cell hyperplasia is considered to be a non-adverse effect when induced by the oral administration of the Platycodi radix water extract once daily for 13 weeks in rats. 相似文献
204.
农村人居环境是乡村地区的短板之一,也是乡村振兴的重要建设内容,探究农村人居环境质量的时空演化特征与驱动因素,可为科学有序推进农村人居环境整治提供理论支撑。本研究以四川省为例,系统梳理了四川省农村人居环境政策,并基于统计年鉴和政府公报数据,运用ArcGIS及地理探测器等工具,探究农村人居环境质量时空演化特征以及驱动因素。结果表明:2005—2019年四川省农村人居环境质量逐渐向好,评价分数由0.260上升到0.917,各市(州)间存在显著的地域差异,呈现东高西低的空间格局;农村人居环境质量变化由社会经济子环境单一驱动转变为社会经济与居住支持环境协同驱动;人均生活消费支出、人均可支配收入、生活污水处理率、乡(镇)拥有卫生院数量、乡(镇)拥有文化站数量是影响农村人居环境质量的主导因素。未来,四川省农村人居环境整治应加强公共资源投入及公共服务建设,尤其应注重偏远地区的农村人居环境提升。 相似文献
205.
一、何为救生犬救生犬是指经过特殊训练的,不需要踪迹就能找到失踪者的犬。它能通过人的气味在无路可行的开阔地或在废墟中找到需要救援的人。救生犬在培训中要适应极高的地方,通过栅栏、挡板和梯子等障碍锻炼。救生犬能不受白天黑夜、气候条件的限制完成任务,也不会因为受到视觉和声觉刺激而中断搜寻。警报、火、烟和其他救援人员或高分贝噪音不会影响救生犬工作。救生犬对人友善,对人或动物没有攻击性。二、救生犬能做什么(一)地面搜寻搜寻链中的一头救生犬在50米宽的走廊地带搜寻,要比使用25名救生人员在同一地带搜寻快5倍。搜寻链可由5… 相似文献
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207.
Wei Chen Kaixiong Ye Xiaoji Zhu Huihui Zhang Ranran Si Jianing Chen Zijun Chen Kaili Song Zhicheng Yu Bingnan Han 《Marine drugs》2022,20(1)
Actinomycins as clinical medicine have been extensively studied, while few investigations were conducted to discover the feasibility of actinomycins as antimicrobial natural dye contributing to the medical value of the functional fabrics. This study was focused on the application of actinomycin X2 (Ac.X2), a peptide pigment cultured from marine-derived Streptomyces cyaneofuscatus, in the dyeing and finishing of silk fabric. The dyeing potential of Ac.X2 with silk vs. cotton fabrics was assessed. As a result, the silk fabric exhibited greater uptake and color fastness with Ac.X2. Through Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray diffraction (XRD) analyses, some changes of chemical property for the dyed fabric and Ac.X2 were studied. The silk fabric dyed with Ac.X2 exhibited good UV protection ability. The antibacterial properties of dyed and finished silk were also evaluated, which exhibited over 90% antibacterial activity even after 20 washing cycles. In addition, the brine shrimp assay was conducted to evaluate the general toxicity of the tested fabric, and the results indicated that the dyed silk fabrics had a good biological safety property. 相似文献
208.
Sohee Kim Tu Cam Le Sang-Ah Han Prima F. Hillman Ahreum Hong Sunghoon Hwang Young Eun Du Hiyoung Kim Dong-Chan Oh Sun-Shin Cha Jihye Lee Sang-Jip Nam William Fenical 《Marine drugs》2022,20(1)
Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ-490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7-chloro-4(1H)-quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti-quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560. 相似文献
209.
210.
为比较杭白菊主栽品种早、晚小洋菊对菊小长管蚜Macrosiphoniella sanborni、棉蚜Aphis gossypii、桃蚜Myzus persicae的抗性,通过刺吸电位技术(electrical penetration graph,EPG)研究菊蚜在菊顶叶上刺吸行为,并检测了菊顶叶主要化合物。结果表明:在晚小洋菊上,菊小长管蚜的E1、E2波平均持续时间4.31、3.47 min,分别短于在早小洋菊上的4.63、3.75 min;棉蚜、桃蚜的E1、E2波平均持续时间分别为4.32、4.72 min和4.92、4.64 min;3种蚜虫的平均刺探次数均大于在早小洋菊上的平均刺探次数。聚类分析结果显示,2个主栽品种之间抗性存在差异。早小洋菊顶叶平均可溶性糖和可溶性蛋白含量分别为2.71 mg/g和25.36 mg/g,均高于晚小洋菊;早小洋菊顶叶总酚含量为0.24 mg/g,显著低于晚小洋菊;早、晚小洋菊总黄酮含量分别为3.46 mg/g和3.37 mg/g。早小洋菊顶叶可溶性糖、可溶性蛋白含量基本上与每种菊蚜的E1、E2波持续时间显著正相关,总酚含量、总黄酮含量与每种菊蚜的E1或E2波持续时间显著负相关。推测早小洋菊对于菊长管蚜的抗性稍弱于晚小洋菊,2种杭白菊对棉蚜或桃蚜的抗性相当,且菊叶中的这4种物质含量与抗蚜性相关。 相似文献