Antigenic stability of fimbriae of Bacteroides nodosus

Successful vaccination of sheep against footrot and attempts to eradicate the disease depend on there being a limit to the antigenic diversity of the causative bacterium, Bacteroides nodosus. Fimbrial antigenic variation was therefore investigated in vivo, both under conditions of chronic infection and under the pressure of a vaccine-induced immune response, to ascertain whether this represented an obstacle to such goals. Material was available from 5 experiments and although B. nodosus appeared to have undergone changes in its fimbrial antigens in one of these, the possibility that superinfection was responsible for the variation detected could not be ruled out because all sheep in this case were maintained at pasture. Overall, the results provided no evidence of fimbrial antigenic shift in B. nodosus in vivo and in conclusion, the survival of the organism in the sheep's foot, both in long-term natural infection and following vaccination, must therefore be related to factors other than the ability to undergo antigenic variation in order to evade the host's immune response.     

康氏木霉的寄生性及其在防治棉花立枯病中的应用

研究结果显示,康氏木霉(Trichoderma koningii)以菌丝缠绕、博贴等形式寄生于病例菌的菌丝上,吸取其营养,并产生抑菌物质,致使病茵丝的断裂,原生质凝固,直至死亡.大田小区实验和大面积防治示范部表明,康氏木霉可有效防治棉立枯病(Rhizoclonia solani)等土传病害,降低其发病率和发病程度.