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241.
Neena SINGLA Gaganpreet KAUR Bhupinder Kaur BABBAR Bhupinder Singh SANDHU 《Integrative zoology》2013,8(3):260-276
Mature and healthy male house rats, Rattus rattus (n= 160) were fed on bait (cracked wheat: powdered sugar, 98:2) containing different concentrations of triptolide (0.1, 0.05, 0.025 and 0%) for 7 and 14 days in no‐choice and bi‐choice feeding tests in the laboratory. The objective of the study was to record the antifertility affects of triptolide after 30 and 60 days of termination of treatment. Results revealed no significant effect of triptolide treatment on weights of testis, epididymis, seminal vesicles and prostate gland of rats. Overall, sperm motility, live sperm count, sperm density and sperm morphology in the cauda epididymal fluid were found to differ significantly (P≤ 0.05) between untreated and treated groups of rats. The major effect of triptolide on sperm morphology was in the form of sperm head tail separation, which was up to 56.0% in rats treated for 14 days in no‐choice and autopsied after 30 days. A significant effect (P≤ 0.05) of triptolide treatment was observed on the histomorphology of the testis, which included a dose‐dependent decrease in diameter of seminiferous tubules, thickness of germinal epithelium and numbers of various spermatogenic cells. Cell associations in the seminiferous epithelial cycle were poorly developed in rats ingesting medium (4.7–5.1 mg/100 g bw) and high doses (6.9–7.2 mg/100 g bw) of triptolide than rats ingesting low doses (1.8–2.3 mg/100 g bw) and untreated rats. The cell stages affected had not recovered fully within the 60 day period following triptolide withdrawal. The present study suggests the potential of triptolide in reproductive management of Rattus rattus. 相似文献
242.
Ravinder Sappal Rakesh Kumar Chaudhary Harpal Singh Sandhu Pritam Kaur Sidhu 《Veterinary research communications》2009,33(7):659-667
Pharmacokinetics, urinary excretion and plasma protein binding of danofloxacin was investigated in buffalo calves following
intravenous administration at the dose rate of 1.25 mg/kg to select the optimal dosage regimen of danofloxacin. Drug concentrations
in plasma and urine were measured by microbiological assaying. In vitro plasma protein binding was determined employing the equilibrium dialysis technique. The distribution and elimination of danofloxacin
were rapid, as indicated by values (mean ±SD) of distribution half-life (t1/2α = 0.16 ± 0.07 h) and elimination half-life (t1/2β = 4.24 ± 1.78 h), respectively. Volume of distribution at steady state (Vss) = 3.98 ± 1.69 L/kg indicated large distribution
of drug. The area under plasma drug concentration versus time curve (AUC) was 1.79 ± 0.28 μg/mlxh and MRT was 8.64 ± 0.61 h.
Urinary excretion of danofloxacin was 23% within 48 h of its administration. Mean plasma protein binding was 36% at concentrations
ranging from 0.0125 μg/ml to 1 μg/ml. On the basis of pharmacokinetic parameters obtained, it is concluded that the revision
of danofloxacin dosage regimen in buffalo calves is needed because the current dosage schedule (1.25 mg/kg) is likely to promote
resistance. 相似文献
243.
Kumar Antul Sharma Achla Sharma Rajni Choudhary Anuj Srivastava Puja Kaur Harmanjot Padhy Asish Kumar 《Genetic Resources and Crop Evolution》2022,69(1):411-430
Genetic Resources and Crop Evolution - Gradual deterioration in water resources and unpredictable distribution pattern of annual precipitation amount are major threats having drastic effects on... 相似文献