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101.
Journal of Plant Diseases and Protection - Coffee berry disease (Colletotrichum kahawae) causes fruits rots on Arabica coffee leading to harvest losses of around 40%. Using biological molecules may... 相似文献
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Genoveffa Nuzzo Giuseppina Senese Carmela Gallo Federica Albiani Lucia Romano Giuliana dIppolito Emiliano Manzo Angelo Fontana 《Marine drugs》2022,20(6)
Cancer is one of the leading causes of death globally. Anticancer drugs aim to block tumor growth by killing cancerous cells in order to prevent tumor progression and metastasis. Efficient anticancer drugs should also minimize general toxicity towards organs and healthy cells. Tumor growth can also be successfully restrained by targeting and modulating immune response. Cancer immunotherapy is assuming a growing relevance in the fight against cancer and has recently aroused much interest for its wider safety and the capability to complement conventional chemotherapeutic approaches. Natural products are a traditional source of molecules with relevant potential in the pharmacological field. The huge structural diversity of metabolites with low molecular weight (small molecules) from terrestrial and marine organisms has provided lead compounds for the discovery of many modern anticancer drugs. Many natural products combine chemo-protective and immunomodulant activity, thus offering the potential to be used alone or in association with conventional cancer therapy. In this review, we report the natural products known to possess antitumor properties by interaction with immune system, as well as discuss the possible immunomodulatory mechanisms of these molecules. 相似文献
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AC Johnstone BI Davidson AR Roe MR Eccles RD Jolly 《New Zealand veterinary journal》2013,61(5):307-314
AIM: To describe the pathology and inheritance of a congenital polycystic kidney disease (PKD) of sheep. METHODS: Mode of inheritance of PKD was investigated by evaluation of results of the disorder from planned matings in two consecutive years within subsets of a flock that had a high prevalence of PKD in lambs. Gross pathological and histopath- ological studies were based on tissues derived from this study. Haematoxylin and eosin (H&E)-stained paraffin sections of kidney, liver, extrahepatic biliary and pancreatic ducts, pancreas and epididymis were used to describe the lesions. RESULTS: Twenty-five lambs affected by PKD, of both sexes, were born, numbers in accord with those expected for an autosomal recessive disorder in the population studied. In all cases for which tissues were available, the renal, bile ductal (intrahepatic and extrahepatic), pancreatic and epididymal tissues had widespread dysplastic changes and associated cyst formation. CONCLUSIONS: The findings of renal cysts in conjunction with cysts in other organs are unifying features in many of the human and animal forms of PKD and suggest a related pathogenic and genetic base consistent with an autosomal recessive disorder. 相似文献
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Rienske AR Mortier Herman W Barkema Karin Orsel Robert Wolf Jeroen De Buck 《Veterinary research》2014,45(1):71
Although substantial fecal shedding is expected to start years after initial infection with Mycobacterium avium subspecies paratuberculosis (MAP), the potential for shedding by calves and therefore calf-to-calf transmission is underestimated in current Johne’s disease (JD) control programs. Shedding patterns were determined in this study in experimentally infected calves. Fifty calves were challenged at 2 weeks or at 3, 6, 9 or 12 months of age (6 calves served as a control group). In each age group, 5 calves were inoculated with a low and 5 with a high dose of MAP. Fecal culture was performed monthly until necropsy at 17 months of age. Overall, 61% of inoculated calves, representing all age and dose groups, shed MAP in their feces at least once during the follow-up period. Although most calves shed sporadically, 4 calves in the 2-week and 3-month high dose groups shed at every sampling. In general, shedding peaked 2 months after inoculation. Calves inoculated at 2 weeks or 3 months with a high dose of MAP shed more frequently than those inoculated with a low dose. Calves shedding frequently had more culture-positive tissue locations and more severe gross and histological lesions at necropsy. In conclusion, calves inoculated up to 1 year of age shed MAP in their feces shortly after inoculation. Consequently, there is potential for MAP transfer between calves (especially if they are group housed) and therefore, JD control programs should consider young calves as a source of infection. 相似文献
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A Matini Behzad B Ebrahimi AR Alizadeh V Esmaeili A Dalman L Rashki AH Shahverdi 《Reproduction in domestic animals》2014,49(4):599-605
Our aim was to evaluate the effects of fish oil feeding on sperm classical parameters, level of reactive oxygen spices (ROS), spermatozoa death incidence and in vitro fertilization (IVF) rate in rams. We randomly assigned nine rams, into two experimental groups (isoenergetic and isonitrogenous rations with constant level of vitamin E supplement): control (CTR; n = 5) and fish oil (FO; n = 4, 35 g/day/ram). Diets were fed for 70 days during the physiological breeding season. After a 21‐day dietary adaptation period, semen was collected weekly from each ram by an artificial vagina. Sperm classical parameters were determined by the computer‐assisted sperm analyzer system (CASA), and it was prepared for IVF process by swim‐up technique. These evaluations were performed during the first and last weeks of sampling. Intracellular ROS level and spermatozoa death incidence were detected by flow cytometry on a weekly basis after adaptation. Data were analysed with SPSS 15. The volume, concentration (3.6 and 2.7 × 109/ml) and sperm progressive motility (60 and 48%) were significantly improved in the FO group compared with the CTR (p < 0.05). A comparison of two‐cell stage embryos following IVF in the two groups showed a significantly higher fertilization rate in the FO group (56%) compared with the CTR (49%). Superoxide anion (O2?) rate was significantly lower (p < 0.05) at the third week of sampling in the FO. Although the H2O2 rate was numerically lower in the FO group compared with the CTR, this difference was not significant. In addition, apoptosis showed a significant difference in the third week of sampling (15 and 30% for FO and CTR, respectively; p < 0.05). Overall, adding fish oil to the ram diet not only improved sperm quality and IVF results, it also could reduce oxygen‐free radicals and the incidence of spermatozoa death. 相似文献
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Paolo Tarolli Giulia Sofia Simone Calligaro Massimo Prosdocimi Federico Preti Giancarlo Dalla Fontana 《Land Degradation \u0026amp; Development》2015,26(1):92-102
Vineyard landscapes are a relevant part of the European culture, and several authors concluded that they are the agricultural practice that causes the highest soil loss. Grape quality depends on the availability of water, and soil erosion is an important parameter dictating the vineyard sustainability; therefore, soil and water conservation measures are often implemented. Among them, the construction of terraces is the most widely used system. However, while favouring agricultural activities, terraces if not properly maintained can lead to local instabilities creating hazards for settlements and cultivations, and for the related economy. Terraced fields are also served by agricultural roads that can have deep effects on water flows triggering surface erosion. The goal of this research is to use lidar elevation data for a hydro‐geomorphological analysis of terraced vineyards. The work is divided in two parts. At first, the Relative Path Impact Index is tested in two vineyards to identify terrace‐induced and road‐induced erosions. Statistical thresholds of the Relative Path Impact Index are then defined to label the most critical areas. On the second step, using the index and the defined thresholds, we simulate different scenarios of soil conservation measures, establishing the optimal solution to reduce erosion. The results highlight the effectiveness of high‐resolution topography in the analysis of surface erosion in terraced vineyards, when the surface water flow is the main factor triggering the instabilities. The proposed analysis can help in scheduling a suitable planning to mitigate the consequences of the anthropogenic alterations induced by the terraces and agricultural roads. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
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