Cationic antimicrobial peptides are present throughout the plant and animal kingdoms and bear striking structural and functional similarities across species lines. They provide primitive, nonspecific means of combating a variety of bacteria, fungi, enveloped viruses, and protozoa. Some are also cytotoxic against host cells, including neoplastic cells. Cationic antimicrobial peptides may play various roles in inflammation and tissue repair. Antimicrobial peptides are found in epithelial tissues regularly exposed to microbial attack as well as in cells whose primary function is defense against potential pathogens. They constitute an important part of the nonoxidative antimicrobial arsenal of leukocytes. They are preformed and/or readily synthesized when the cells are stimulated by exposure to pathogens. They exert their effects directly by inserting into membranes of target cells and forming ion channels which increase membrane permeability; however, antimicrobial peptides can also act as opsonins to facilitate phagocytosis. Resistance to defensins is a virulence factor for organisms such as Salmonella sp. The study of cationic antimicrobial peptides is increasing our understanding of innate immunity, inflammation, and the pathogenesis of genetic diseases such as specific granule disease in humans. Therapeutic applications of antimicrobial peptides are currently under investigation. 相似文献
The relationship between fine-scale spatial patterns of forage abundance and the feeding patterns of large ungulates is not well known. We compared these patterns for areas grazed in winter by elk and bison in a sagebrush-grassland landscape in northern Yellowstone National Park. At a fine scale, the spatial distribution of mapped feeding stations in 30 m × 30 m sites was found to be random where there were no large patches devoid of vegetation. In areas similar to the mapped sites, the underlying spatial distribution pattern of biomass was also determined to be random. At a broad scale, forage biomass differed among communities across the northern range but forage quality did not. These results suggest that ungulates are feeding randomly within forage patches (fine scale) but may select feeding sites based upon forage abundance at broader, landscape scales. Contrary to what has been suggested in other systems, ungulates were not overmatching at finer scales. 相似文献
1. Pullets of 2 high‐producing commercial stocks (both brown‐egg layers) were exposed to 5 different lighting patterns between 18 and 72 weeks to test the hypothesis that photoperiods used in commercial lighting programmes early in the laying year may be unnecessarily long and, by accelerating the development of photorefractoriness, may contribute to the decline in egg production observed after the initial peak. Two rooms of 288 pullets were allocated to each treatment.
2. The rate of lay observed with a Step‐Up treatment which gave increases in photoperiod from 8L:16D at 18 weeks to 15L:9D at 27 weeks of age was not significantly different from that of treatments which held the birds on 11L:13D during peak egg production but gave increments up to 15L:9D later in the laying year.
3. A control group maintained on 11L:13D from 20 to 72 weeks laid 295 eggs per bird housed and a further group held on 8L:16D from 0 to 72 weeks laid 284 eggs per bird. These yields were lower than the Step‐Up treatment (299 eggs) but show the potential of modern hybrid stocks to lay prolifically even without light stimulation.
4. It is concluded that the stocks tested in this experiment showed no advantage when given lighting programmes in the first laying year which were designed to minimise the adverse effects of photorefractoriness. 相似文献
Twenty-four Thoroughbred and twelve Standardbred racehorses aged between 2 and 6 years, presented for reported poor racing performance, underwent clinical exercise testing. During the last 10 s of exercise at each speed throughout an incremental speed exercise test on a treadmill inclined at a 10% slope, samples of arterial blood and expired gases were collected. Maximum oxygen uptake and the partial pressures of oxygen and carbon dioxide in arterial blood were determined. These values were compared between the two breeds of horses and also with reference to cytological findings of bronchoalveolar lavage samples, including neutrophil, erythrocyte and haemosiderophage percentage and the total nucleated cell concentration. The results revealed an inverse relationship (Spearman R = -0.45, p < 0.05) between the total nucleated cell count in bronchoalveolar lavage samples and arterial oxygen partial pressure during exercise at 11 m.s(-1). This result suggests that subclinical pulmonary disease may be a more important cause of poor racing performance than previously thought. Also of note was a positive correlation (Spearman R = 0.50, p < 0.05) between maximum oxygen uptake and the percentage of erythrocytes. 相似文献
The efficacy of an ivermectin jetting fluid against the sheep body louse, Bovicola (Damalinia) ovis, in long-woolled sheep was investigated in three field trials. In all trials, louse populations in hand-jetted sheep were reduced to nondetectable numbers within 2 weeks of treatment. Bv comparison, shorn and unshorn control sheep maintained detectable infestations for the duration of the trials. 相似文献
Two cats with chronic eosinophilic skin disease were investigated. The clinical investigation of the skin disease in one cat was limited and inflammatory bowel disease was diagnosed post mortem. A history of weight loss and a palpably thickened bowel in the second cat suggested concurrent gastrointestinal disease. Diagnosis of inflammatory bowel disease was confirmed on biopsy. Treatment with azathioprine and methylprednisolone acetate resolved the signs of gastrointestinal disease, the pruritus and 95% of the skin lesions. The concurrence of eosinophilic papulocrustous dermatitis and eosinophilic bowel disease raises the possibility of their being linked bv a common aetiology or pathophysiology. 相似文献
Veterinarians commonly predict mature heart scores for yearling and 2-year-old horses to aid clients in assessing a horse's racing potential. Sixty-six thoroughbreds were assessed as a yearlings or 2-year-olds, then re-assessed as a mature horse (over the age of 3). Of these horses, 82% of the yearlings and 87% of the 2-year-olds had a correctly predicted mature heart score within one heart score range (i.e. three points). 相似文献
1. ISA Brown hens were housed as groups of 4 from 18 to 72 weeks in 24 cages 450 mm deep, each with a softwood perch of rectangular cross‐section fitted across the rear. There were 4 treatments, each with 6 cages: cage widths and perch lengths were 480, 520, 560 or 600 mm.
2. Daytime perching did not differ significantly between the treatments. At night, over the whole year, 81% of birds in the 480 mm cages and 86% in the 520 mm cages roosted on the perch. This figure reached about 95% in the 560 and 600 mm cages, significantly more at most ages than in the 480 mm cages.
3. Feather damage was slightly less, but claw problems slightly more, in the 2 wider treatments than in the 2 narrower treatments. Birds in the wider cages were calmer when approached or handled by humans than those in the narrower cages. This may have been associated with variation in space allowance between the treatments.
4. There was a trend for lower production in the 480 mm cages than in the other treatments which may have been associated with the reduced feeding space in this treatment. There were few other treatment differences in production traits.
5. The balance of the evidence from this study is that when perches are provided in laying cages for medium weight hybrids, 140 mm of perch space per hen is adequate. For the amelioration of a number of the welfare problems of conventional cages, provision of perches should be combined with other modifications. 相似文献