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101.
Tetragonal zirconium oxide, stable at room temperature, was synthesized at 15 to 20 kb and 12000 to 17000C. Rapid quenching produced a mixture of the monoclinic and tetragonal phases. The high-pressure specimens, when heated to 1200 degrees C in air and quenched, reverted to the all-monoclinic form. 相似文献
102.
Genes can affect natural behavioral variation in different ways. Allelic variation causes alternative behavioral phenotypes, whereas changes in gene expression can influence the initiation of behavior at different ages. We show that the age-related transition by honey bees from hive work to foraging is associated with an increase in the expression of the foraging (for) gene, which encodes a guanosine 3',5'-monophosphate (cGMP)-dependent protein kinase (PKG). cGMP treatment elevated PKG activity and caused foraging behavior. Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior. 相似文献
103.
Robinson AL 《Science (New York, N.Y.)》1974,185(4154):846-848
104.
Robinson AL 《Science (New York, N.Y.)》1974,184(4138):785-787
105.
Robinson AL 《Science (New York, N.Y.)》1979,205(4413):1367
106.
Robinson AL 《Science (New York, N.Y.)》1983,220(4603):1259-1261
107.
Robinson AL 《Science (New York, N.Y.)》1982,217(4558):435-436
108.
Robinson AL 《Science (New York, N.Y.)》1977,195(4284):1315-1367
109.
110.
Transducin activation by rhodopsin without a covalent bond to the 11-cis-retinal chromophore 总被引:3,自引:0,他引:3
Rhodopsin and the visual pigments are a distinct group within the family of G-protein-linked receptors in that they have a covalently bound ligand, the 11-cis-retinal chromophore, whereas all of the other receptors bind their agonists through noncovalent interactions. The retinal chromophore in rhodopsin is bound by means of a protonated Schiff base linkage to the epsilon-amino group of Lys-296. Two rhodopsin mutants have been constructed, K296G and K296A, in which the covalent linkage to the chromophore is removed. Both mutants form a pigment with an absorption spectrum close to that of the wild type when reconstituted with the Schiff base of an n-alkylamine and 11-cis-retinal. In addition, the pigment formed from K296G and the n-propylamine Schiff base of 11-cis-retinal was found to activate transducin in a light-dependent manner, with 30 to 40% of the specific activity measured for the wild-type protein. It appears that the covalent bond is not essential for binding of the chromophore or for catalytic activation of transducin. 相似文献