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The present investigation describes the synthesis and characterization of novel biodegradable nanoparticles based on chitosan for biomedical applications. The presence of primary amine groups in repeating units of chitosan grants it several properties like antibacterial activity, antitumor activity and so on. Chitosan forms nanoparticles spontaneously on the addition of polyanion tripolyphosphate which has greater antimicrobial activity than parent chitosan. In the present study, chitosan nanoparticles (ChNP) were prepared by the ionic gelation method. The physiochemical characteristics of nanoparticles were analyzed using XRD, SEM, FTIR. The antibacterial activity of chitosan nanoparticles against medical pathogens Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was evaluated by calculation of minimum inhibitory concentration (MIC) and compared with chitosan and chitin activity. The mode of action and factors affecting antibacterial activity were also analyzed. ChNP compounds exhibited superior antimicrobial activity against all microorganisms in comparison with chitosan and chitin. The antibiofilm activity was studied using crystal violet assay and growth on congo red agar. The study is thus a good demonstration of the applicability of chitosan nanoparticles as an effective antimicrobial agent with antibiofilm activity as well. 相似文献
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Pareek Shalini Jaiswal Poonam Subhash Shrivastava Divya 《Genetic Resources and Crop Evolution》2022,69(7):2279-2290
Genetic Resources and Crop Evolution - Guar (Cyamopsis tetragonoloba (L.) Taub.), or cluster bean, traditionally grown for vegetable and fodder, has gained commercial importance across the globe... 相似文献
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Surfaces of raw wool fibers possess high amounts of greasy substances that need to be removed prior to further processing. Acidic lipases using Bacillus licheniformis (MTCC 2618) were produced with the optimum activity levels closer to the room temperature. Scouring of wool fibers using mesophile acidic lipase has been attempted, in the present work, as an alternative to the existing alkaline treatment and the samples were assessed in terms of weight loss, moisture regain, tenacity, elongation, surface appearance, and friction of the fibers. The lipase scoured wool fibers showed moisture regain and weight loss values comparable to that of alkaline treatment, with lower static and dynamic frictional coefficients. Higher tenacity and elongation values were observed in the lipase scoured fibers compared to the alkaline scoured samples and clear appearance of the surface, compared to the raw wool fibers, was also observed in the lipase scoured samples. 相似文献
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Jeyavani Jeyaraj Sibiya Ashokkumar Sivakamavalli Jeyachandran Divya Mani Preetham Elumalai Vaseeharan Baskaralingam Faggio Caterina 《Aquaculture International》2022,30(2):1071-1086
Aquaculture International - Aquaculture-based foods have enriched nutritional and medicinal value to meet the needs of the global population. Recently, improper maintenance of aquatic organisms in... 相似文献