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Lefaucheur L Lebret B Ecolan P Louveau I Damon M Prunier A Billon Y Sellier P Gilbert H 《Journal of animal science》2011,89(4):996-1010
Residual feed intake (RFI) is defined as the difference between the observed feed intake and that expected based on requirements for maintenance and production. A divergent selection was conducted during 4 generations in Large White male pigs to produce low and high RFI lines. The present study aims at determining the influence of this selection on biochemical and histological traits of skeletal muscle, and relating these changes to correlated effects on growth, carcass composition, and meat quality traits. At 8 d preslaughter, biopsies from the LM were taken in the fed state on 14 females from each RFI line fed ad libitum. Animals were slaughtered at 107.8 ± 8.0 kg of BW without any previous fasting. Samples of LM, semimembranosus (SM), biceps femoris (BFM), and rhomboideus muscles were taken at both 30 min and 24 h postmortem. Myofiber typing was only assessed in LM. Low RFI pigs ("efficient") had leaner carcasses with greater muscle content (P < 0.001), less backfat thickness (P < 0.001), and less intramuscular fat content in all 4 muscles (P < 0.01 to P = 0.04). Their greater muscle content was associated with hypertrophy of all fast-twitch fibers. Glycogen content in all glycolytic muscles (i.e., LM, SM and BFM), was greater in low than high RFI pigs. The greater accumulation of glycogen in LM of low RFI pigs was specifically located in the fast-twitch glycolytic IIBW fibers, which correspond to fibers containing IIb, IIb + IIx, or IIx myosin heavy chains. The difference in muscle glycogen content between RFI line pigs was more significant in the living animals (P = 0.0003) than at 30 min postmortem (P = 0.08). This was associated with a decreased ultimate pH (P = 0.001), and greater lightness of color (P = 0.002) and drip loss (P = 0.04) in LM of low than high RFI line pigs, suggesting that selection for reduced RFI may impair some meat quality traits, such as water-holding capacity. Pigs from the low RFI line exhibited a greater (P = 0.02) percentage of IIBW fibers in LM and tended (P < 0.10) to have less lipid β-oxidative capacity in LM, SM, and BFM. In contrast, no difference (P > 0.10) between lines was found for citrate synthase and lactate dehydrogenase activities, mitochondrial activity, and expression of genes coding for uncoupling proteins 2 and 3. Differences between RFI pigs in plasma leptin, cortisol, and thyroid hormone concentrations are presented and discussed. In conclusion, selection for low RFI influenced muscle properties in a way favoring muscle mass, but likely impairing meat quality. 相似文献
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The Effects of Substituting Selected Oilseed Protein Concentrates for Fish Meal in Rainbow Trout Oncorhynchus mykiss Diets 总被引:3,自引:0,他引:3
Robert R. Stickney Ronald W. Hardy Kim Koch Robert Harrold Damon Seawright Kenneth C. Massee 《Journal of the World Aquaculture Society》1996,27(1):57-63
Three oilseed protein concentrates (soybean, canola, and sunflower) were evaluated to determine their potential, when supplemented with deficient essential amino acids, to partially or completely replace fish meal in diets fed to rainbow trout Oncorhynchus mykiss . Triplicate aquaria of juvenile trout (average weight of 12 g) were fed the experimental diets for 10 wk, at which time the average weight of the fish was approximately sixfold higher than the initial weight. Average fish weight gains on diets in which the protein component was 100% fish meal; 75% fish meal, 25% soybean protein concentrate; 50% fish meal, 50% soybean protein concentrate; and 75% fish meal, 25% sunflowerseed protein concentrate were not significantly different ( P < 0.05). The average weight of fish fed a commercial feed was significantly lower than that of fish fed the 100% fish meal diet, but not significantly different from fish fed the three other formulations mentioned above. Fish fed diets containing 50% fish meal, 50% canola protein concentrate; and 25% fish meal, 75% sunflowerseed protein concentrate had significantly lower average final weights than those of fish fed the other diets. Feed conversion ratio patterns among the dietary treatment groups reflected those of weight gain. Fish survival exceeded 95% on all diets. Apparent protein digestibility coefficients ranged from 79.5% (75% soybean protein concentrate, 25% canola protein concentrate) to 90.6% (100% soybean protein concentrate). The results of this study demonstrated that certain oilseed protein concentrates have good potential as protein sources in rainbow trout feeds when properly supplemented with essential amino acids. 相似文献
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Heidi McDevitt Christopher Stauthammer Damon Leeder Melissa Hanson Janet Olson Daniel Gruenstein 《Journal of Veterinary Cardiology》2013,15(3):211-216
Unilateral absence of the left or right pulmonary artery with concurrent contralateral pulmonary arterial branch stenoses is an exceptionally rare disorder. We describe this anomaly in a cat with severe exercise intolerance and respiratory distress. Transthoracic echocardiography and angiography demonstrated the absence of the left pulmonary artery with concurrent right pulmonary branch stenosis. Palliative balloon angioplasty of the right pulmonary artery substantially reduced right ventricular systolic pressure load and alleviated the patient's clinical signs. 相似文献
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Endris RG Hair JA Anderson G Rose WB Disch D Meyer JA 《Veterinary therapeutics : research in applied veterinary medicine》2003,4(1):47-55
The efficacy of two formulations of a topically applied 65% permethrin spot-on (Defend Exspot Treatment for Dogs, Schering-Plough Animal Health) was evaluated against experimental infestations of the cat flea Ctenocephalides felis and the lone star tick Amblyomma americanum in dogs. Eighteen dogs were randomly assigned to treatment with 65% permethrin in either diethylene glycol monomethyl ether (DGME; original formulation) or propylene glycol monomethyl ether (PGME) or to be untreated as a control. Treated dogs received either 1 (body weight < 15 kg) or 2 ml (body weight > or =15 kg) of the assigned formulation on Day 0. One hundred unfed, adult C. felis were placed on each dog on Days -6, -1, 4, 11, 18, 25, and 32. Fifty unfed, adult ticks were placed on each dog on Days -1, 3, 9, 16, 23, and 30. Live fleas and ticks were counted and removed on Days 3, 7, 14, 21, and 28. Treatment of dogs with the 65% permethrin in DGME reduced flea numbers by 90.4% to 99.9% from Days 3 through 21 (P < or =.05) and by 48.2% 28 days after treatment. Treatment of dogs with 65% permethrin in PGME reduced flea numbers by 93.7% to 99.7% from Days 3 through 28 and by 78.4% 35 days after treatment (P < or =.05). Treatment with 65% permethrin in DGME reduced tick numbers by 90% or more only on Day 7, whereas treatment with 65% permethrin in PGME reduced the number of live ticks by 90%or more on Days 7 and 14 and approached 90%(87.9%) on Day 21. Efficacy against fleas and ticks for the PGME formulation was significantly better (P < or =.05) than for the DGME formulation on Day 28. Findings in this study indicate that both the DGME and PGME formulations of 65% permethrin performed well in reducing numbers of live C. felis and A. americanum on laboratory beagles; however, the PGME formulation was effective approximately 1 to 2 weeks longer than the DGME formulation. 相似文献
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Wu B Chien EY Mol CD Fenalti G Liu W Katritch V Abagyan R Brooun A Wells P Bi FC Hamel DJ Kuhn P Handel TM Cherezov V Stevens RC 《Science (New York, N.Y.)》2010,330(6007):1066-1071
Chemokine receptors are critical regulators of cell migration in the context of immune surveillance, inflammation, and development. The G protein-coupled chemokine receptor CXCR4 is specifically implicated in cancer metastasis and HIV-1 infection. Here we report five independent crystal structures of CXCR4 bound to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution. All structures reveal a consistent homodimer with an interface including helices V and VI that may be involved in regulating signaling. The location and shape of the ligand-binding sites differ from other G protein-coupled receptors and are closer to the extracellular surface. These structures provide new clues about the interactions between CXCR4 and its natural ligand CXCL12, and with the HIV-1 glycoprotein gp120. 相似文献
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Shammas K. O'Connell A. M. Grove T. S. McMurtrie R. Damon P. Rance S. J. 《Biology and Fertility of Soils》2003,38(4):228-235
Amounts of nutrients in harvest residues and their contribution to nutrient cycling were quantified following logging of a Eucalyptus globulus plantation in south-western Australia. An estimated 64 t ha–1 of leaf, bark and branch material less than 3 cm in diameter was deposited on the forest floor during harvesting. Leaves contributed about one-third of the residue dry weight but accounted for almost three-quarters of residue-N stores (299 of 428 kg N ha–1) and 36% to 52% of P, K, Ca, and Mg stores. Stores of nutrients in slash were significant in comparison to amounts in surface soil (0–20 cm). Residue-N amounted to 11% of total surface soil N and cations stored in residues were equivalent to 23–114% of surface soil exchangeable cations. Decomposition of the leaf fraction of slash was rapid with more than 90% of dry weight released during the 105-week study. Bark and branch fractions of diameters 0.5, 1 and 2 cm lost 39%, 37%, 32% and 29% of dry weight, respectively, during the same period. Single and double exponential decay models fitted to the data indicated half lives ranging from 20 weeks for leaves and from 3 to 4 years for bark and the branch fractions. During decomposition, K was leached rapidly from all residue fractions, Mg and P were released at similar rates to dry weight, and Ca and N were released more slowly than dry weight. In the 105-week study period, 250 kg ha–1 of N, 20 kg ha–1 of P, 213 kg ha–1 of Ca, 298 kg ha–1 of K, and 63 kg ha–1 of Mg were returned to the soil from decomposing harvest slash. The leaf fraction was the major contributor to nutrient cycling, accounting for almost all of the N and Ca release and from half to three-quarters of the K, Mg and P released. Amounts of nutrients released from residues in the year following logging greatly exceeded quantities likely to be taken up by the newly established tree crop. 相似文献
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Elizabeth M. Glenn Damon B. Lesmeister Raymond J. Davis Bruce Hollen Anne Poopatanapong 《Landscape Ecology》2017,32(3):563-579