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21.
Fuji RN Patton KM Steinbach TJ Schulman FY Bradley GA Brown TT Wilson EA Summers BA 《Veterinary pathology》2005,42(5):608-617
A rare, multisystemic intravascular proliferative disorder was identified postmortem in eight cats. The majority of these cats died or were euthanized following episodes of dyspnea, lethargy, and anorexia. Microscopic examination revealed occlusive, intraluminal proliferations of spindle cells within small vessels. The heart was consistently involved, and myocardial dysfunction was the probable cause of illness in all cats. Immunohistochemically, the majority of intravascular cells expressed von Willebrand factor, and a smaller number expressed smooth muscle actin, compatible with a dual population of endothelial cells and pericytes, suggesting a reactive rather than a neoplastic process. Four cases of a similar feline vascular disorder from the veterinary literature are reviewed. The histopathology resembles reactive angioendotheliomatosis in humans, a benign cutaneous intravascular endothelial and pericytic proliferative condition. However, in contrast, this feline disease is multisystemic and fatal. We propose the name "feline systemic reactive angioendotheliomatosis" for this unique, idiopathic disorder of domestic cats. 相似文献
22.
Schulman ML Marlow CH Nurton JP 《Journal of the South African Veterinary Association》2003,74(1):17-19
The data and an analysis of the statistical summaries from the 'Return of Mares' of the General Stud Book of The Jockey Club of Southern Africa from 1975-1999 are presented. The total number of mares covered per season ranged from 7393 (1992) to 5180 (1995). The total living produce in the period surveyed was 95 317 foals. The categories of data examined include: the total number of mares covered per season; the total numbers and percentage of their living produce; the total numbers and percentage dead produce, 'slips' and foals born dead, barren and 'no return' mares; and the total number of live twins reported. The percentage live foals per season increased from 52 to 62% and the percentage barren and 'no return' mares declined from 35.50 to 28.40% over the period surveyed. The number of live twins reported showed a dramatic reduction from 156 to 5. These apparent improvements are ascribed to a combination of factors including advances in veterinary knowledge and technology. The findings are similar to those reported by similar surveys of national Thoroughbred populations from North America and Germany. There is an indication to broaden this annual survey by recording additional parameters more accurately reflecting reproductive efficiency rather than a cumulative annual total of live foals. 相似文献
23.
24.
J C Patterson-Kane F Y Schulman N Santiago L McKinney C J Davis 《Veterinary pathology》2001,38(6):712-714
A 3-year-old female neutered Staffordshire Bull Terrier presented with a mixed germ cell tumor involving the base of the iris and the ciliary body of the right eye. The tumor mass was composed primarily of packeted vacuolated, polygonal (hepatoid) cells and small round cells; epithelial cells lining tubuloacinar structures were a less prominent component. The hepatoid and round cells stained positively for alpha-fetoprotein and cytokeratin. The epithelial cells stained positively for cytokeratin only, and some contained cytoplasmic mucin droplets. The polygonal cells were interpreted as a hepatoid variant of yolk sac tumor, and the epithelial cells were considered a teratomatous component. Trabeculae of bone were observed within the mass and may have been metaplastic or a teratomatous element. Extragonadal germ cell tumors are rare in dogs and have previously been reported only in the suprasellar region. This is the first report of this tumor type in the eye of a nonhuman species. 相似文献
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26.
Twenty-three feline cutaneous fibropapillomas with histologic features similar to equine sarcoids were diagnosed. They were characterized by dermal fibroblastic proliferation with overlying, often ulcerated hyperplastic epidermis. Electron microscopic findings supported the fibroblastic nature of the neoplastic cells. The 23 tumors came from 20 cats and were submitted from veterinary clinics in Wisconsin and Minnesota. These tumors occurred most commonly in young cats and were found primarily on the head, neck, and digits. Fifteen of the 17 cats for which breed was reported were domestic shorthair cats. In 11/20 cases, there was confirmed exposure to cattle. Local recurrence of the tumor following surgical excision was reported in 7 of the 18 cats for which follow-up information was available. Metastasis was not documented in any of the cases. Two of the 19 tumors tested by polymerase chain reaction (PCR) had no amplifiable DNA. The remaining 17 were positive for papillomavirus by PCR. No papillomavirus DNA was detected in three other feline skin tumors (cutaneous mast cell tumor, malignant lymphoma, and fibrosarcoma) that served as controls. This is the first report of detection of papillomavirus in feline tumors that have clinicopathologic features similar to equine sarcoids. 相似文献
27.
28.
Kiupel M Webster JD Bailey KL Best S DeLay J Detrisac CJ Fitzgerald SD Gamble D Ginn PE Goldschmidt MH Hendrick MJ Howerth EW Janovitz EB Langohr I Lenz SD Lipscomb TP Miller MA Misdorp W Moroff S Mullaney TP Neyens I O'Toole D Ramos-Vara J Scase TJ Schulman FY Sledge D Smedley RC Smith K W Snyder P Southorn E Stedman NL Steficek BA Stromberg PC Valli VE Weisbrode SE Yager J Heller J Miller R 《Veterinary pathology》2011,48(1):147-155
Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of different grading systems by veterinary pathologists and institutional modifications make the prognostic value of histologic grading highly questionable. To evaluate the consistency of microscopic grading among veterinary pathologists and the prognostic significance of the Patnaik grading system, 95 cutaneous MCTs from 95 dogs were graded in a blinded study by 28 veterinary pathologists from 16 institutions. Concordance among veterinary pathologists was 75% for the diagnosis of grade 3 MCTs and less than 64% for the diagnosis of grade 1 and 2 MCTs. To improve concordance among pathologists and to provide better prognostic significance, a 2-tier histologic grading system was devised. The diagnosis of high-grade MCTs is based on the presence of any one of the following criteria: at least 7 mitotic figures in 10 high-power fields (hpf); at least 3 multinucleated (3 or more nuclei) cells in 10 hpf; at least 3 bizarre nuclei in 10 hpf; karyomegaly (ie, nuclear diameters of at least 10% of neoplastic cells vary by at least two-fold). Fields with the highest mitotic activity or with the highest degree of anisokaryosis were selected to assess the different parameters. According to the novel grading system, high-grade MCTs were significantly associated with shorter time to metastasis or new tumor development, and with shorter survival time. The median survival time was less than 4 months for high-grade MCTs but more than 2 years for low-grade MCTs. 相似文献
29.
A. Schulman 《Acta veterinaria Scandinavica》1982,23(2):153
The heart and liver functions, blood electrolytes and acid-base balance were studies in halothane-sensitive and nonsensitive pigs. An inhibition of the hyperthermia reaction was attempted by an i.v. injection of propranolol. The pulse rate of sensitive pigs was shown to be elevated already at the beginning of halothane narcosis. No other differences between sensitive and nonsensitive pigs were observed from the electrocardiogram. Ectopic beats and arythmia appeared only in 1 halothane-sensitive pig which died soon after the test. The serum OCT-activity showed no abnormalities. Hyperkalemia and acidosis occurred but the Ga++ was not elevated in halothane-sensitive animals. The slight elevation in Na+ was thought to be caused by hemoconcentration. A propranolol injection only delayed but did not inhibit the halothane reaction. 相似文献
30.
An unusual portosystemic shunt in a dog 总被引:1,自引:0,他引:1
An unusual portosystemic shunt was diagnosed in a 4-month-old male Miniature Poodle examined because of stunted growth and episodes of dementia characterized by hysteria, ataxia, and staggering. Operative splenoportography revealed a portosystemic shunt. Exploratory surgery to identify and correct the shunt was attempted. Evidence of any portal circulation was not detected, and the dog was euthanatized. The possible embryologic basis for this vascular anomaly is discussed. 相似文献