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11.
Oncolytic potential of rodent parvoviruses for cancer therapy in humans: a brief review 总被引:2,自引:0,他引:2
Geletneky K Herrero Y Calle M Rommelaere J Schlehofer JR 《Journal of veterinary medicine. B, Infectious diseases and veterinary public health》2005,52(7-8):327-330
Summary Rodent parvoviruses are promising candidates for oncolytic virotherapy of cancer in humans because of their oncotropism (preferential killing of transformed cells) in the absence of pathogenicity. Here, we give an overview concerning the possible application of parvovirus H-1 for cancer therapy, with specific emphasis on malignant brain tumours in humans. 相似文献
12.
M Asakawa JW Ludders B Badgley HN Erb LP Posner RD Gleed 《Veterinary anaesthesia and analgesia》2005,32(4):12-13
Adenosine is a potent analgesic in people and reduces the MAC of halothane in dogs. The purpose of this study was to determine whether adenosine reduces the MAC of isoflurane in dogs. Seven beagles (four males and three females) were anesthetized and randomly assigned to receive adenosine (0.3 mg kg–1 minute–1; 6 mL kg–1 hour–1, IV) or saline (0.9%, 6 mL kg–1 hour–1IV). After an interval of ≥7 days, each dog was reanesthetized and treated with the alternate infusion. Anesthesia was induced and maintained with isoflurane in oxygen. Dogs were intubated and instrumented for measurement of mean systemic arterial blood pressure and airway concentration of isoflurane and end‐tidal partial pressure of carbon dioxide. The MAC for isoflurane was determined using the tail‐clamp technique. Baseline MAC values were 1.25 (1.15, 1.35)% [median (minimum, maximum)] and 1.25 (1.05, 1.45)% before the saline and adenosine treatments, respectively. After 2 hours of infusion with saline or adenosine, MAC values were not different (p = 0.156) and were 1.25 (0.95, 1.35)% and 1.05 (1.00, 1.25)%, respectively. Two hours following the end of each infusion, the MAC values for saline and adenosine treatment groups differed significantly (p = 0.015), but by no more than the normal variation inherent in this study, and were 1.15 (1.15, 1.35)% and 1.05 (1.05, 1.25)%, respectively. Mean arterial blood pressure was 93 (74, 123) mm Hg for saline treated dogs and 67 (52, 72) mm Hg (p = 0.008) during adenosine infusion. End‐tidal carbon dioxide was not different between the two treatment groups. We conclude that adenosine administered at 0.3 mg kg–1 minute–1had no effect on isoflurane MAC in dogs, but decreased mean arterial blood pressure. 相似文献
13.
Herpesvirus-associated papillomas in koi carp (Cyprinus carpio). 总被引:1,自引:0,他引:1
From January through November 1994, 32% (7/22) of koi carp (Cyprinus carpio) maintained in indoor aquariums developed proliferative cutaneous lesions that consisted of single to multiple 2-10-mm whitish to pink fleshy masses usually associated with fin rays. Although scaleless koi were more commonly affected (3/6) than were normally scaled koi (4/16), the difference in incidence rates was not significant (chi2 text, P > 0.05). Lesions typically resolved spontaneously in 1-3 wk, occasionally persisted for >3 mo, and recurred in several fish after 2-5 mo. Fish were otherwise asymptomatic. Wet mount preparations from lesions were densely cellular and consisted of hyperplastic epidermal cells of normal morphology without parasites or inflammatory cells. Histologically, biopsies were consistent with papillomas and were characterized by a marked benign epidermal hyperplasia without inclusion bodies or inflammatory infiltrate. Transmission electron microscopic examination revealed intranuclear and intracytoplasmic herpesvirus virions. Virus isolation attempts were unsuccessful. 相似文献
14.
Kristine M Smith Paul Calle Bonnie L Raphael Stephanie James Robert Moore Denise McAloose Eric Baitchman 《Journal of zoo and wildlife medicine》2006,37(1):44-48
Medical records of three male and three female callitrichids of four species (Leontopithecus chrysopygus, Leontopithecus rosalia, Callithrix argentata argentata, Callithrix kuhlii) diagnosed with cholelithiasis were reviewed. Ages of affected animals at the time of diagnosis ranged from 2-14 yr. Definitive antemortem diagnosis of cholelithiasis was made in four of the six cases. Chronic weight loss, lethargy, and weakness were seen in all cases. Chronic intermittent diarrhea was seen in three cases. Icterus and abnormal gait were each present in two of the animals. Hematologic and serum biochemical abnormalities included leukocytosis in five cases, elevated bilirubin (direct and indirect) in four cases, and anemia in four cases. Radiographic evidence of choleliths was observed in three cases. Surgical removal of choleliths was successfully performed on two animals. Full necropsies were performed on all cases, and choleliths were believed to contribute to morbidity in all cases. However, inflammatory bowel disease was determined to be the primary cause of weight loss and mortality in at least three animals. All choleliths analyzed were pigment stones, two being primarily composed of cystine. 相似文献
15.
以发生于本市的一起兔病毒性出血症与大肠杆菌病混合感染的病例为题材,从发病情况、临床症状、病变、实验室检查、防治等几个方面作了详尽的阐述,为临床上治疗该病提供参考依据。 相似文献
16.
Pathology of fatal West Nile virus infections in native and exotic birds during the 1999 outbreak in New York City, New York 总被引:9,自引:0,他引:9
17.
People in vast areas of the tropics suffer from vitamin A deficiency, resulting in progressive eye damage and eventually leading
to blindness. Improving the content of vitamin A precursors in staple crops could alleviate or solve such a problem. The objective
of this work was to study the range of variability for carotene content in a sub-set of the global cassava germplasm collection,
and to determine the inheritance of carotenes, as well as their stability in response to different processing methodologies.
Genotypes with more than 2 mg carotenes/100 g of fresh roots have been selected as parental material for population development.
Although root colour is highly correlated with carotene content, a quantitative evaluation of genotypes selected by colour
is required in order to increase the efficiency of selection. Relatively few major genes are involved in the determination
of carotene accumulation in cassava roots. Stability of carotenes in response to different processing methods is genotypically
dependant, representing a trait to be evaluated after selecting for high carotene concentration in fresh roots. The results
from this work have provided the basis for defining future strategies for the improvement of the nutritional quality of cassava.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
18.
Enrique MurgueitioZoraida Calle Fernando UribeAlicia Calle Baldomero Solorio 《Forest Ecology and Management》2011,261(10):1654-1663
Extensive cattle production currently occupies more than 27% of the rural landscapes in Latin America, and continues to expand. This activity, deeply rooted in the culture and rural economy of the region, requires an urgent transformation if it is to become both more efficient and environmentally friendly. Silvopastoral systems that incorporate native trees and shrubs are instrumental for the productive rehabilitation of cattle production and for biodiversity conservation in agricultural landscapes. We discuss research progress and adoption of intensive silvopastoral systems in Colombia and Mexico. Intensive silvopastoral systems (ISS) are a sustainable form of agroforestry for livestock production that combines fodder shrubs planted at high densities (more than 10,000 plants ha−1), trees and palms, and improved pastures. High stocking and the natural production of milk and meat in these systems are achieved through rotational grazing with electric fencing and a permanent supply of water for the cattle. While milk and meat production and cattle reproduction are enhanced, production costs decline as external inputs are replaced by natural processes related to fertility and biological control. We also discuss the importance of the ISS with native trees for climate change adaptation and mitigation, the barriers for their adoption, and how these have been successfully addressed using payment for environmental services, special credits and technical assistance. Finally, we highlight the need for enhancing landscape connectivity by integrating SPS to conservation corridors with native species to promote biodiversity conservation and other environmental services demanded by society. 相似文献
19.
Donald L Neiffer Edwin C Klein Paul P Calle Michael Linn Scott P Terrell Rodney L Walker Donna Todd Carol C Vice Steven K Marks 《Journal of zoo and wildlife medicine》2002,33(3):242-248
Two adult North American river otters (Lontra canadensis) and an adult red panda (Ailurus fulgens fulgens) at three separate institutions died within 22 hr after receiving single 2.5- to 2.7-mg/kg doses of melarsomine dihydrochloride administered in the epaxial musculature as a treatment for filarid nematodes. One otter had a suspected Dirofilaria immitis infection, the other had a confirmed D. lutrae infection, and the red panda had a confirmed Dirofilaria sp. infection, presumably with D. immitis. Postmortem examinations revealed similar gross lesions, although they were less severe in the red panda. The trachea and primary bronchi contained abundant foamy fluid, the lungs were mottled with areas of consolidation, and the pulmonary parenchyma exuded abundant fluid at the cut section. Histologic evaluation revealed acute pulmonary edema, which resulted in respiratory failure and death. There may have been direct pulmonary cellular toxicity of melarsomine dihydrochloride or a severe systemic anaphylactic reaction to antigens released after parasite death. An idiosyncratic drug reaction or a low therapeutic index of melarsomine probably caused the death of the three individuals. Melarsomine dihydrochloride use should be avoided in North American river otters and red pandas. 相似文献
20.
H Chevalier LP Posner JW Ludders HN Erb RD Gleed 《Veterinary anaesthesia and analgesia》2003,30(2):114-114
Our purpose was to assess the accuracy and precision of a point of care hemoglobinometer (HemoCue‐B hemoglobin photometer) for measuring hemoglobin concentration in horse blood. Samples of jugular venous blood from 12 healthy adult horses were collected in EDTA. In order to test the device over a wide range of values, each sample was divided into nine aliquots, and autologous plasma was added or removed from the aliquots to produce blood with PCV values that approximated 5, 10, 20, 30, 40, 50, 60, 70, and 80%, respectively. The aliquots were rocked to ensure mixing of plasma and cells. Then hemoglobin by HemoCue‐B (HbHQ) and hemoglobin by the cyanmethemoglobin method (HbCY) were measured on each aliquot. The PCV of each aliquot was also measured and this value was used for subsequent analyses. To test repeatability, hemoglobin was measured twice by the HemoCue‐B on approximately 40% samples. Samples with HbHQ >25.4 g dL?1 required dilution prior to analysis. HbCY ranged from 1.6 to 33.4 g dL?1. After regression, HbCY = ?0.16 + 1.04 HbHQ (n = 101; r2 = 99.6%). By inspection of a modified Bland‐Altman plot, HbHQ values <16 g dL?1 closely approximated HbCY; however, at greater values, HbHQ underestimated HbCY by as much as 3.2 g dL?1. The difference between repeated measurements with the HemoCue‐B was 0.02 ± 0.16 g dL?1 (mean ± SD; n = 10) and nonsignificant. After regression, PCV = ?0.76 + 2.78 HbHQ (n = 101; r2 = 99.4%). We conclude that HemoCue‐B can be used to measure hemoglobin concentration in horse blood, and that it is accurate when hemoglobin is <16 g dL?1. PCV can be estimated by multiplying HbHQ by 2.8 and then subtracting 0.8. 相似文献