A 12‐year‐old spayed English pointer dog developed multiple skin lesions including pigmented viral plaques, basal cell carcinomas, squamous cell carcinomas and trichoblastomas. Canine papillomavirus type 3 was detected in multiple lesions suggesting common aetiology.
Dietary supplements that promote healthy aging are mostly warranted in an aging society. Because of age-related risks, anti-inflammatory and anti-oxidative agents such as microalgae are potential candidates for intervention. In a randomized controlled trial, we tested Phaeodactylum tricornutum (PT), a microalgae rich in eicosapentaenoic acid (EPA), carotenoids, vitamins, and β-glucans, cultured in bioreactors. In this pilot trial, 19 healthy elderly received supplements for two weeks based on either the whole PT (A), the β-1,3-glucan-rich PT supernatant (SupB), the combination thereof (A+SupB), or a Comparator product (Comp). The primary outcome variable plasma interleukin-6 was reduced after treatment with A+SupB compared to the Comp group (p = 0.04). The mobility parameters 5 s sit-to-stand test (p = 0.04 in the A group) and by trend gait speed (p = 0.08 in the A+SupB diet) were improved compared to Comp. No treatment effects were observed for fatty acids, compared to Comp but omega-6 to -3 fatty acid ratio (p = 0.006) and arachidonic acid/EPA ratio (p = 0.006) were reduced within group A+SupB. Further, the SupB study product reduced faecal zonulin (p = 0.03) compared to the Comp. The data revealed an anti-inflammatory and potentially anti-oxidative effect of particular PT preparations, suggesting that they might be suitable for effects in healthy elderly. 相似文献
Background:The study of the peculiarities of the anatomy of sheep and rabbits’ digestive systems is an important way to improve the efficiency of these animals’ breeding.Aim:The aim of the presented research was to study structural changes of such digestive glands as the liver and the pancreas which occur in the process of ontogenesis in sheep and rabbits.Methods:Sheep of the “Kazakh fat-tailed semi-coarse-wooled” breed (n = 8) raised in the “Sayan” private peasant agriculture and rabbits of the “Grey Giant” breed (n = 8), raised on the mini rabbit farm of the Agriculture Faculty of Shakarim University were used in the research.Two experimental animal groups were formed (of sheep, “Kazakh fat-tailed semi-coarse-wooled” breed, n = 8; rabbits, “Grey Giant” breed, n = 8). The liver and pancreas’ ontogenesis development has been studied in these animals.Results:The study presents a holistic view of the macro-microscopic structure of the liver and the pancreas of animals in crucial age periods, stages, and phases of postembryonic ontogenesis (by the example of sheep and rabbits). The authors have traced age stages of adaptive change and structural-functional change of stromal-parenchymatous structures of the liver in sheep and rabbits taking into account stages and crucial phases of development.Conclusion:Development of the liver and the pancreas are characterized by discontinuous growth in the process of postnatal ontogenesis. A crucially important period is the first months after birth, during which the weight and functionality of these organs grow rapidly. 相似文献
