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2. The responses of birds pretreated as described above to a single injection of corticotrophin (30 IU/kg) were determined.
3. A similar degree of hyperglycaemia had developed in both groups after 2 h but thereafter the responses differed: the concentration of plasma glucose did not increase further in those pretreated with corticotrophin and had begun to decrease at 6 h, whereas that of the birds pretreated with saline increased progressively.
4. The concentrations of plasma corticosterone had increased similarly in the two groups to a peak at 2 h but there was a significantly more rapid decrease in the birds pretreated with corticotrophin.
5. Both groups showed a transient hypercholesteraemia but the increase was significant only in the group that had previously received saline.
6. There were decreases in the concentrations of adrenal cholesterol in both groups. The decrease, in absolute terms, was 2–4 times greater in the group receiving corticotrophin for the first time: percentage changes were similar, however. 相似文献
2. Hyperphagia, amounting to twice the intake of control birds early in the experiment, occurred on the repletion day.
3. Final body weight attained 80% of that of the controls.
4. Body fat concentration decreased at first but returned to that of controls after 3 weeks.
5. A consistent hyperlipaemia was observed after food deprivation or restoration.
6. There was a marked increase in the digestive enzymes found in the small intestine, but not in the pancreas during the repletion day.
7. These responses may be considered as mechanisms to reduce the physiological manifestations of starvation. 相似文献