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排序方式: 共有186条查询结果,搜索用时 15 毫秒
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182.
Ruggeri L Capanni M Urbani E Perruccio K Shlomchik WD Tosti A Posati S Rogaia D Frassoni F Aversa F Martelli MF Velardi A 《Science (New York, N.Y.)》2002,295(5562):2097-2100
T cells that accompany allogeneic hematopoietic grafts for treating leukemia enhance engraftment and mediate the graft-versus-leukemia effect. Unfortunately, alloreactive T cells also cause graft-versus-host disease (GVHD). T cell depletion prevents GVHD but increases the risk of graft rejection and leukemic relapse. In human transplants, we show that donor-versus-recipient natural killer (NK)-cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD. In mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GVHD. NK cell alloreactivity may thus provide a powerful tool for enhancing the efficacy and safety of allogeneic hematopoietic transplantation. 相似文献
183.
Gambacorta A Tofani D Bernini R Migliorini A 《Journal of agricultural and food chemistry》2007,55(9):3386-3391
The unprecedented acetonide of the antioxidant hydroxytyrosol has been synthesized by a two-step high-yielding procedure and found to be both purifiable by chromatography and stable over a wide pH range. The protection stabilizes hydroxytyrosol against oxidation, thereby allowing long-term storage. The protection can quantitatively be removed, under nonaqueous conditions, to afford pure hydroxytyrosol suitable for use as an additive in food and cosmetic preparations. Extension of the same methodology to the natural and easily accessible glycoside oleuropein, followed by saponification of the resulting complex mixture of acetonides, allowed hydroxytyrosol acetonide to be recovered in high yield. This constitutes a new interesting methodology to obtain the antioxidant hydroxytyrosol. 相似文献
184.
Pasqualone A Montemurro C Grinn-Gofron A Sonnante G Blanco A 《Journal of agricultural and food chemistry》2007,55(9):3312-3318
The aim of this work was to evaluate the analysis of DNA microsatellites for the detection of soft wheat (Triticum aestivum L.) in semolina and durum wheat bread (prepared from Triticum turgidum L. var. durum). The results enabled selection of an efficient D-genome-specific repetitive DNA sequence to detect common wheat in semolina and breads by qualitative PCR with a threshold of 3 and 5%, respectively, lowered to 2.5% by real-time PCR. This is of major importance for checking during production of some typical products recently awarded the European Protected Designation of Origin (PDO) mark such as Altamura bread, which should not contain soft wheat flour. The feasibility of quantification of common wheat adulteration in semolina using real-time PCR was also demonstrated. 相似文献
185.
Giacomo Fais Alessia Manca Federico Bolognesi Massimiliano Borselli Alessandro Concas Marco Busutti Giovanni Broggi Pierdanilo Sanna Yandy Marx Castillo-Aleman Ren Antonio Rivero-Jimnez Antonio Alfonso Bencomo-Hernandez Yendry Ventura-Carmenate Michela Altea Antonella Pantaleo Gilberto Gabrielli Federico Biglioli Giacomo Cao Giuseppe Giannaccare 《Marine drugs》2022,20(5)
Spirulina is the most studied cyanobacterium species for both pharmacological applications and the food industry. The aim of the present review is to summarize the potential benefits of the use of Spirulina for improving healthcare both in space and on Earth. Regarding the first field of application, Spirulina could represent a new technology for the sustainment of long-duration manned missions to planets beyond the Lower Earth Orbit (e.g., Mars); furthermore, it could help astronauts stay healthy while exposed to a variety of stress factors that can have negative consequences even after years. As far as the second field of application, Spirulina could have an active role in various aspects of medicine, such as metabolism, oncology, ophthalmology, central and peripheral nervous systems, and nephrology. The recent findings of the capacity of Spirulina to improve stem cells mobility and to increase immune response have opened new intriguing scenarios in oncological and infectious diseases, respectively. 相似文献
186.