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21.
Mariano Catanesi Giulia Caioni Vanessa Castelli Elisabetta Benedetti Michele dAngelo Annamaria Cimini 《Marine drugs》2021,19(1)
Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs’ neuroprotective potential for neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties. 相似文献
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Roberto Chiocchetti Cristiano Bombardi Caterina Mongardi-Fantaguzzi Elena Venturelli Domenico Russo Alessandro Spadari Corrado Montoneri Noemi Romagnoli Annamaria Grandis 《Research in veterinary science》2009,87(2):177-185
This paper describes the morphology and distribution of the enteric nervous system (ENS) cells and fibres immunoreactive for choline acetyltransferase (ChAT), neuronal nitric oxide synthase (nNOS), substance P (SP), calcitonin gene-related peptide (CGRP), NF200 kDa (NF200), and S100 protein. The percentages of subclasses of enteric neurons in the total neuronal population were investigated by the use of anti-PGP 9.5 or anti-NSE antibodies.ChAT-IR myenteric plexus (MP) and submucosal plexus (SMP) neurons were 66 ± 7% and 74 ± 15%, respectively, whereas those cells expressing nNOS-IR were 38 ± 7% and 5 ± 1%, respectively. MP and SMP neurons expressing both phenotypes were also present. SP-IR was expressed by 14 ± 13% of MP and 66 ± 8% of SMP neurons whereas CGRP-IR was observed only in the SMP (43 ± 6%). NF200-IR was expressed by 61 ± 15% and 91 ± 10% of the MP and SMP neurons, respectively. The majority of the CGRP-IR SMP neurons expressed also SP-IR. Almost all SP-IR neurons in both the plexuses were cholinergic. The present study quantifies the main neuronal subpopulations of the ENS of the horse ileum; these data might be utilized to understand the neuronal modifications which occur in several gastrointestinal tract disorders. 相似文献
23.
Detection and phylogenetic characterization of astroviruses in insectivorous bats from Central‐Southern Italy 下载免费PDF全文
Maria Grazia Amoroso Danilo Russo Gianvito Lanave Luca Cistrone Annamaria Pratelli Vito Martella Giorgio Galiero Nicola Decaro Giovanna Fusco 《Zoonoses and public health》2018,65(6):702-710
In recent years, bats have been found to harbour many viruses, raising several questions about their role as reservoirs and potential disseminators of zoonotic viruses. We investigated the presence of six virus families in bats in three regions of Central‐Southern Italy. Astroviruses were identified in seven of 13 bat species. Sequence analysis revealed marked genetic heterogeneity among the astroviruses identified, with nucleotide identity ranging between 60.26% and 87.62%. Astrovirus diversity was not associated with the bat species, the geographic areas or the bat colony, suggesting the circulation of several astrovirus strains in Italian ecosystems. Genetic diversification and interspecies transmission appear common in bat astroviruses and could provide, potentially, the bases for transmission to humans and other mammals. Yet overemphasizing this risk might have detrimental consequences for bat conservation and preservation of the important ecosystem services bats provide. 相似文献
24.
Zotta T Piraino P Ricciardi A McSweeney PL Parente E 《Journal of agricultural and food chemistry》2006,54(7):2567-2574
Model wheat doughs started with six different lactic acid bacteria (LAB), with or without a commercial baker's yeast culture, were used to study proteolysis in sourdough fermentations. Cell counts, pH, and free amino acid concentration were measured. Sequential extraction of dough samples was performed to separate wheat proteins. The salt-soluble protein fraction (albumins and globulins) was analyzed by RP-HPLC and SDS-PAGE, whereas propanol-soluble (gliadins) and insoluble (glutenins) protein fractions were analyzed by SDS-PAGE only. Multivariate statistical methods were used for the analysis of results. The presence of yeasts and LAB affected RP-HPLC and SDS-PAGE patterns of the salt-soluble fraction in a complex way. The only changes in the gluten proteins that could be related to the presence of LAB were the appearance of new protein fragments (20 and 27 kDa) from gliadins and the degradation of high molecular weight glutenin subunits. 相似文献
25.
QoI fungicides, inhibitors of mitochondrial respiration at the Qo site of cytochrome b in the mitochondrial bc(1) enzyme complex, are commonly applied in vineyards against Plasmopara viticola (Berk. & MA Curtis) Berl. & De Toni. Numerous treatments per year with QoI fungicides can lead to the selection of resistant strains in the pathogen population owing to the very specific and efficient mode of action. In order to evaluate the resistance risk and its development, two different methods, biological and molecular, were applied to measure the sensitivity of oospores differentiated in vineyards, both treated and untreated with azoxystrobin, from 2000 to 2004. Assays using oospores have the advantage of analysing the sensitivity of bulked samples randomly collected in vineyards, describing accurately the status of resistance at the end of the grapevine growing season. Both methods correlated well in describing the resistance situation in vineyards. QoI resistance was not observed in one vineyard never treated with QoI fungicides. In the vineyard where azoxystrobin had been used in mixture with folpet, the selection of QoI-resistant strains was lower, compared with using solely QoI. In vineyards where QoI treatments have been stopped, a decrease in resistance was generally observed. 相似文献
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Carmela Riefolo Annamaria Castrignanò Claudio Colombo Massimo Conforti Sergio Ruggieri Carolina Vitti 《Archives of Agronomy and Soil Science》2020,66(10):1436-1448
ABSTRACT In some regions of Italy, low-intensity farming systems, together with variable climate conditions, have lowered soil organic carbon (SOC) content and soil quality attributes. This work aims to investigate on some aspects of (1) total organic carbon (TOC) prediction using Vis-NIR reflectance spectroscopy in combination with partial least squares regression (PLSR); (2) the most appropriate pre-processing techniques of Vis-NIR absorbance spectra; (3) the composition of organic carbon using variable importance of prediction (VIP). The study area was an olive grove, located at Montecorvino Rovella (Salerno, southwestern Italy), characterized by a calcaric soil (Leptic Calcisols) and (Luvic Phaeozem), with a low content of TOC (mean 2.03 g kg?1), caused by a low-intensity farming. Results of univariate PLSR analyses showed a good agreement between measured and predicted values both for TOC (R2: 0.66) and total carbonate content (R2: 0.93), when pH, electrical conductivity (EC) and absorbance spectra were used as predictors. The best results were obtained using as pre-treatments of the spectral data: 1) standard normal variate (SNV); 2) Savitzky-Golay algorithm; 3) first derivative. Variable Importance for Prediction (VIP) statistics showed to be a good tool to gain insights in TOC composition also when its content is low and influenced by carbonate. 相似文献
28.
Michela Pugliese Vito Biondi Annamaria Passantino Francesca Licitra Angela Alibrandi Antonina Zanghi Francesca Conte Gabriele Marino 《Animal Science Journal》2021,92(1):e13546
The present study aimed to compare the welfare of dairy cows kept in two traditional husbandry systems (semi-intensive and intensive farming) in south-eastern Sicily. A total of 18 dairy farms (nine semi-intensive and nine intensive) were evaluated with a multicriteria system adapted for Sicilian conditions and obtained simplifying the model of the European Food Safety Authority (EFSA). Values of welfare measures, collected by inspections of the farms (general well-being indicators, ventilation system, resting areas [cubicles or bedding], flooring, milking parlours and waiting area, manger and watering equipment), and those of health categories (cases of abortions, hypocalcemia, displacement of abomasum, acidosis/ketosis, enteritis, hoof problems, and mastitis) obtained through the farm records, were compared using Mann–Whitney and Chi-squared tests, respectively. Data showed significant differences (p ≤ .05) about the variables related to welfare categories such as housing ventilation system, resting area, manger, and water equipment that were better in the semi-intensive system than the intensive system. No significant differences were observed about the variables related to health indicators. The results demonstrated that in Sicily the semi-intensive farm is better than the intensive to satisfy the conditions of animal welfare. 相似文献
29.
The authors carried out microscopic examination of blood smears of 1438 dogs infected with Leishmania infantum. Unusual findings of leishmaniosis associated with circulating parasitised cells are described in four dogs. Most of the dogs presented severe illness, with lethargy, dysorexia, emaciation and alterations of the haematological pattern (anaemia, thrombocytopenia, neutrophilia and monocytosis). In three cases, leishmaniosis was associated with ehrlichiosis. On examination of peripheral blood smears, Leishmania sp. amastigotes were observed both in various circulating leukocytes (neutrophil, monocyte, macrophage) and free. In conclusion, parasites can rarely be detected in blood smears (in 0.28% of the animals examined); thus, the time-consuming microscopic search for amastigotes can make only a weak contribution to the conventional diagnosis of canine leishmaniosis. 相似文献
30.
Silvia Laura Toffolatti Marisol Prandato Luca Serrati Helge Sierotzki Ulrich Gisi Annamaria Vercesi 《European journal of plant pathology / European Foundation for Plant Pathology》2011,129(2):331-338
QoI resistance in P. viticola was first detected in France and Italy in 1999. Molecular and biological assays have been carried out since 2000 in order
to provide reliable methods of detecting and quantifying resistance. Oospores were collected in vineyards located in northern
and southern Italy. QoI resistance was evaluated by the germination rate of oospores on azoxystrobin amended medium and the
frequency of mutant alleles in the DNA extracted from oospores. Both methods correlated to each other and were used side by
side to test QoI resistance. Due to the spontaneous occurrence of the G143A mutation in wild type populations and the immigration
from surrounding vineyards, resistance frequencies up to 10% were found in samples collected from vineyards never treated
with QoIs. Particularly high values, about 90%, were associated with the application of five to six QoI treatments within
the same season, while lower percentages, about 30%, were detected in vineyards treated with QoI used in mixture with fungicides
belonging to a different resistance group. A progressive decrease of resistance frequency was observed when QoI applications
were reduced in number or completely suspended for at least one season. Therefore, a full recovery of sensitivity may be achieved
even in vineyards characterized by high levels of resistance, if particular care is taken during disease control by using
QoIs only in mixtures and reducing the number of QoI treatments. 相似文献