Primary renal neoplasia of dogs

BACKGROUND: Primary renal tumors are diagnosed uncommonly in dogs. HYPOTHESIS: Signs and survival will differ among different categories of primary renal tumors. ANIMALS: Data were collected from the medical records of 82 dogs with primary renal tumors diagnosed by examination of tissue obtained by ultrasound-guided biopsy, needle aspiration, surgery, or at postmortem examination. METHODS: This was a multi-institutional, retrospective study. RESULTS: Forty-nine dogs had carcinomas, 28 had sarcomas, and 5 had nephroblastomas. The dogs were geriatric (mean 8.1 years; range: 1-17) with a weight of 24.9 kg (range: 4.5-80). Tumors occurred with equal frequency in each kidney with 4% occurring bilaterally. Initial signs included one or more of hematuria, inappetance, lethargy. weight loss, or a palpable abdominal mass. Pain was reported more frequently in dogs with sarcomas (5/28). The most common hematologic abnormalities were neutrophilia (22/63), anemia (21/64), and thrombocytopenia (6/68). Polycythemia was present in 3 dogs and resolved with treatment. Hematuria (28/49), pyuria (26/49), proteinuria (24/50), and isosthenuria (20/56) were the most frequently observed abnormalities on urinalysis. Pulmonary metastases were noted on thoracic radiographs in 16% of dogs at diagnosis. Seventy-seven percent of dogs had metastatic disease at the time of death. Median survival for dogs with carcinomas was 16 months (range 0-59 months), for dogs with sarcomas 9 months (range 0-70 months), and for dogs with nephroblastomas 6 months (range 0-6 months). CONCLUSIONS AND CLINICAL IMPORTANCE: Primary renal tumors in dogs are generally highly malignant with surgery being the only treatment that improves survival.     

Peat leachmound treatment of residential wastewater in sub-Arctic Alaska

In many areas of the North, conventional septic systems cannot be installed or have failed because of inadequate drainage. Conventional domestic, on-site wastewater may contaminate shallow water tables and surface waters. The effectiveness of two pilot peat leachfields in treating septic wastewater was investigated for approximately two years by comparing the quality of the untreated wastewater collected from the septic system lift stations to the quality of the peat leachate. The quality of the leachate, based on parameters such as BOD, COD, TSS, NO₃-N, TKN, total-P, pH, fecal and total coliform bacteria, color, turbidity, and DO, is similar to wastewater that has undergone tertiary treatment. Temperatures below the leachmound distribution pipes ranged between 1° and 6 °C. Clogging of the interstices with an organic slime was not encountered. The results of the study show that peat leachmounds can be adopted to treat residential wastewater in rural sub-Arctic Alaska and other northern tier countries without compromising ground or surface water quality.     

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the "pain" pathway. Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli. VR1-/- mice showed normal responses to noxious mechanical stimuli but exhibited no vanilloid-evoked pain behavior, were impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation. Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia.     

IT field monitoring in a Japanese system of rice intensification (J-SRI)

A demonstration study on Information Technology (IT) field monitoring was conducted in a rice field under the System of Rice Intensification (SRI) environment in Shinshiro City, Aichi Prefecture, Japan. The IT system used in this study consisted of an intelligent sensor node web-server that is equipped with in situ camera and sensor networks for agrometeorological, soil, and plant growth monitoring. Dynamic changes in soil moisture, water level, agrometeorological, and environmental conditions were measured and monitored. With this precision farming set-up, understanding and easy assessment of the salient field conditions and phenomena such as cyclic soil wetting and drying as well as critical crop growth stages were made possible. Based on the findings of the demonstration experiment, the system was effective, reliable, and efficient in monitoring soil moisture parameters and agrometeorological information in remote rice field environment. The actual field conditions were captured well by a combination of images, numerical, and graphical data sets. With this precise information, the frequency of irrigation was found to be every 7 days. The rice field was irrigated up to a moisture level of 0.592 m³/m³ (~600 mV) and allowed to be depleted to a moisture level of 0.417 m³/m³ (~400 mV). With this alternate drying and wetting method (AWD), a 25.71% of irrigation water was saved. In this study, rice production was made more scientific and more reliable. Hence, the use of IT field monitoring system represented a viable medium for the realization of better rice productivity which leads to the ethic of sustainable agriculture.     

Outcome mapping for fostering and measuring change in risk management behaviour among urban dairy farmers in Nairobi, Kenya

A study was undertaken to investigate and mitigate the risk from zoonotic Cryptosporidium associated with dairy farming in Dagoretti division, Nairobi, Kenya. Outcome mapping (OM), a relatively new tool for planning and evaluation, was used to foster and then monitor changes in farmer management of health risks. Elements of the OM framework, including the vision, mission and expected progress markers, were developed in participatory sessions and a set of progress markers was used for monitoring behaviour change in farmers participating in the project (the boundary partners). Behaviour change (the outcome challenge) was supported by a range of awareness and educational campaigns, working with strategic partners (extension agents and administrative leaders). The farmers the project worked with made considerable progress according to the markers; they demonstrated an understanding of cryptosporidiosis, established or maintained clean and well drained cattle sheds, and took conscious effort to reduce possible infection. Farmers who did not participate in the project (non-contact farmers) were found to be less advanced on the progress marker indicators. Non-contact farmers who carried out risk-reducing practices had done so independently of the project team. The administration leaders, as strategic partners, had a positive attitude towards the project and confidence in their ability to support project objectives. The study demonstrates the utility of OM in helping to identify and support behavioural change.     

Efforts Toward Improving Maize Yields on Smallholder Farms in Uasin Gishu County,Kenya, through Site-specific,Soil-testing-based Fertiliser Recommendations: A Transdisciplinary Approach

This study evaluated the effects of site-specific, soil-testing-based fertiliser recommendations on maize yields using the transdisciplinary (TD) process. The TD process utilizes knowledge from science and practice. Farmers, extension officers, local financial institutions, and other practitioners collaborated with local scientists from the University of Eldoret in the process of financing, purchasing, and applying fertilisers in adequate amounts and composition. A total of 144 farmers participated in the study, which lasted for two seasons. The data sampling was based on a randomized 2?×?3?×?4?×?2 factorial complete block design, including the following factors: TD (non-participation vs participation in the TD process); ST (soil testing in the following categories: fertiliser application with no soil testing, fertiliser application following government recommendations, and application of site-specific, soil-testing-based fertiliser recommendations), and location (Kapyemit, Kipsomba, Ng’enyilel, and Ziwa). The “no soil testing” (ST₁) category refers to farmers’ own practices at an average fertilisation of about 60?kg?N?ha^?1 and 15?kg?P?ha^?1. The government recommendation (ST₂) calls for 75?kg?N?ha^?1, 25?kg?P?ha^?1, and 6?t?ha^?1 manure, and site-specific fertiliser recommendations (ST₃) were based on actual soil-testing results; generally, this resulted in the recommendation of 90?kg?N?ha^?1, 30?kg?P?ha^?1, 25 kg K ha^?1, 2?t?ha^?1 lime, and 1?t?ha^?1 manure. Highly significant effects were seen where farmers participated in the TD process (TD) for soil testing (ST). The farmers’ yields in Uasin Gishu County of 4.5?t?ha^?1 increased by approximately 1.5?t?ha^?1 based on site-specific, soil-testing fertilisation recommendations and by approximately 1.0?t?ha^?1 based on participation in the transdisciplinary process. However, as indicated by a significant interaction of the variables ST and TD—and while there is a significant main effect of participating in a TD process—the latter increase occurs only if site-specific, soil-testing-based recommendations can be used in the transdisciplinary process with farmers.