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991.
Park C Lim CY Kim JH Jang JI Park HM 《The Canadian veterinary journal. La revue veterinaire canadienne》2011,52(2):165-168
A 5-year-old, intact male, golden retriever was presented with an acute onset of lethargy and respiratory distress. The dog was diagnosed as having rodenticide intoxication with pericardial effusion. Pericardiocentesis was successfully performed and was followed with a blood transfusion. This case suggests that rodenticide intoxication might cause pericardial effusion in dogs. 相似文献
992.
Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs 下载免费PDF全文
M. Giorgi B. Łebkowska‐Wieruszewska A. Lisowski H. Owen A. Poapolathep T. W. Kim V. De Vito 《Journal of veterinary pharmacology and therapeutics》2018,41(3):428-436
Metamizole (MT), an analgesic and antipyretic drug, is rapidly hydrolyzed to the active primary metabolite 4‐methylaminoantipyrine (MAA) and relatively active secondary metabolite 4‐aminoantipyrine (AA). The aim of this study was to assess the pharmacokinetic profiles of MAA and AA after dose of 25 mg/kg MT by intravenous (i.v.), intramuscular (i.m.), oral (p.o.), and rectal (RC) routes in dogs. Six dogs were randomly allocated to an open, single‐dose, four‐treatment, four‐phase, unpaired, crossover study design. Blood was collected at predetermined times within 24 hr, and plasma was analyzed by a validated HPLC‐UV method. Plasma concentrations of MAA and AA after i.v., i.m., p.o., and RC administrations of MT were detectable from 5 (i.v. and i.m.) or 30 (p.o. and RC) min to 24 hr in all dogs. The highest concentrations of MAA were found in the i.v., then i.m., p.o., and RC groups. Plasma concentrations of AA were similar for i.v., i.m., and RC, and the concentrations were approximately double those in the PO groups. The AUCEV/IV ratio for MAA was 0.75 ± 0.11, 0.59 ± 0.08, and 0.32 ± 0.05, for i.m., p.o., and RC, respectively. The AUCEV/IV ratio for AA was 1.21 ± 0.33, 2.17 ± 0.62, and 1.08 ± 0.19, for i.m., p.o., and RC, respectively. Although further studies are needed, rectal administration seems to be the least suitable route of administration for MT in the dog. 相似文献
993.
994.
High levels of estrogen produced by boar testes and the presence of estrogen receptors in both interstitial and tubular compartments are consistent with a direct role for estrogen in regulation of testicular cell function. This study investigated the importance of estrogen on hormone production by Leydig cells and seminiferous tubules in the developing boar. Thirty-six 1-week-old littermate pairs of boars were treated weekly with vehicle or 0.1 mg/kg BW Letrozole, an aromatase inhibitor, until castration at 2, 3, 4, 5, 6, 7, or 8 months. Tissue was collected and Leydig cells and seminiferous tubules were isolated. In a separate study, five untreated boars (ages 1.5-4 months) were castrated and Letrozole was added in vitro to Leydig cell and seminiferous tubule cultures. Leydig cells were cultured for 24h with and without porcine LH. Media were assayed for estradiol (E(2)) and testosterone (T) concentrations by RIA. Seminiferous tubules were cultured for 4h with and without porcine FSH; media were assayed for E(2) and immunoreactive inhibin (INH). In vivo aromatase inhibition decreased basal E(2) and increased basal T production by cultured Leydig cells. Basal seminiferous tubule production of E(2) but not INH was reduced. Decreasing estrogen synthesis in vivo did not alter LH-induced Leydig cell E(2) production or FSH-induced seminiferous tubule INH production. INH production decreased with advancing age regardless of treatment. In conclusion, in vivo aromatase inhibition altered baseline steroid production by cultured Leydig cells and seminiferous tubules but had little effect on response to gonadotropins. 相似文献
995.
Jae-il Lee Myung-jin Kim Chang-sik Park Myung-cheol Kim 《Journal of veterinary science (Suw?n-si, Korea)》2006,7(1):79-81
Renal ischemia as a course of renal transplantation is a common cause of renal dysfunction as renal failure. The purpose of this study was to investigate the influence of ascorbic acid on blood urea nitrogen (BUN), creatinine (Cr) and resistive index (RI) for dog models with renal ischemia-reperfusion (I/R) injury. Renal ischemia was induced on 6 Beagle dogs. The left kidney was exposed to normothermic ischemia for a short period at 30 min followed by reperfusion. On the blood Cr level and RI, there was no significant difference comparing both groups. 14 days after I/R injury a significant reduction on the blood BUN level was observed in the vehicle group (34.06 mg/dl) compared to that of ischemia induced treated group (10.3mg/dl) (p < 0.05). In conclusion, administration of ascorbic acid for renal ischemic-reperfusion injury had influence on blood BUN level, but it was not revealed the influence on blood Cr and RI. 相似文献
996.
Sumin Ji Yeseul Yang Yeji Jeong Sung-Hyun Hwang Myung-Chul Kim Yongbaek Kim 《Journal of veterinary science (Suw?n-si, Korea)》2021,22(1)
BackgroundQuantitation of urine protein is important in dogs with chronic kidney disease. Various analyzers are used to measure urine protein-to-creatinine ratios (UPCR).ObjectivesThis study aimed to compare the UPCR obtained by three types of analyzers (automated wet chemistry analyzer, in-house dry chemistry analyzer, and dipstick reading device) and investigate whether the differences could affect clinical decision process.MethodsUrine samples were collected from 115 dogs. UPCR values were obtained using three analyzers. Bland-Altman and Passing Bablok tests were used to analyze agreement between the UPCR values. Urine samples were classified as normal or proteinuria based on the UPCR values obtained by each analyzer and concordance in the classification evaluated with Cohen''s kappa coefficient.ResultsPassing and Bablok regression showed that there were proportional as well as constant difference between UPCR values obtained by a dipstick reading device and those obtained by the other analyzers. The concordance in the classification of proteinuria was very high (κ = 0.82) between the automated wet chemistry analyzer and in-house dry chemistry analyzer, while the dipstick reading device showed moderate concordance with the automated wet chemistry analyzer (κ = 0.52) and in-house dry chemistry analyzer (κ = 0.53).ConclusionsAlthough the urine dipstick test is simple and a widely used point-of-care test, our results indicate that UPCR values obtained by the dipstick test are not appropriate for clinical use. Inter-instrumental variability may affect clinical decision process based on UPCR values and should be emphasized in veterinary practice. 相似文献
997.
Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus) 总被引:1,自引:0,他引:1
The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish (Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half-life (t(1/2)), the volume of distribution at steady state (V(dss)), and total body clearance were 11.12 +/- 1.06 h, 1.09 +/- 0.09 L/kg and 0.07 +/- 0.01 L x kg/h respectively. After p.o. administration of florfenicol, the t(1/2), C(max), t(max) and oral bioavailability (F) were 15.69 +/- 2.59 h, 9.59 +/- 0.36 microg/mL, 8 h and 92.61 +/- 10.1% respectively. Florfenicol amine, an active metabolite of florfenicol, was detected in all fish. After i.v. and p.o. administration of florfenicol, the observed C(max) values of florfenicol amine (3.91 +/- 0.69 and 3.57 +/- 0.65 mg/L) were reached at 0.5 and 7.33 +/- 1.15 h. The mean metabolic rate of florfenicol amine after i.v. and p.o. administration was 0.4 and 0.5 respectively. 相似文献
998.
Jae-Ku Oem Joon-Yee Chung Yong-Joo Kim Kyoung-Ki Lee Seong-Hee Kim Byeong-Yeal Jung Bang-Hun Hyun 《Journal of veterinary science (Suw?n-si, Korea)》2013,14(2):227-230
Five cases of orf virus infection in Korean black goats were diagnosed in our laboratory between 2010 and 2011. One orf virus (ORF/2011) was isolated from an ovine testis cell line (OA3.Ts) for use as a vaccine candidate. Sequences of the major envelope protein and orf virus interferon resistance genes were determined and compared with published reference sequences. Phylogenetic analyses revealed that orf viruses from Korean black goats were most closely related to an isolate (ORF/09/Korea) from dairy goats in Korea. This result indicates that the orf viruses might have been introduced from dairy goats into the Korean black goat population. 相似文献
999.
Byeong-Sam Kim Mengmeng Gu Kyung-Chul Cho Duck-Soo Choi Bong-Ki Yun Seok-Kyu Jung 《The Journal of Horticultural Science and Biotechnology》2016,91(4):332-340
Oil cake, widely used as an organic source of nutrients in horticultural production in South Korea, is a by-product when oil is extracted from various oilseeds. Split applications of oil cake were supplied to evaluate their effects on tree growth and fruit production in organic, non-astringent persimmon (Diospyros × kaki Thunb.) trees in 2009 and in 2010. Treatments included a single annual application of oil cake at 150 kg N ha?1 in April (single application), two applications in April and July (105 and 45 kg N ha?1, respectively; two-split application), or three applications in April, June, and August (60, 45, and 45 kg N ha?1, respectively; three-split application), as well as zero application of oil cake (control). All applications of oil cake significantly increased the amount of ground-cover vegetation compared to the control. The single and two-split applications increased soil organic matter (OM), K2O, CaO, and MgO concentrations, and cation exchange capacity to a soil depth of 0–30 cm in 2010. Oil cake applications increased soil porosity in 2010, as well as overall chlorophyll (SPAD values) and macronutrient concentrations in leaves in 2009 and 2010. Single and two-split applications stimulated water-sprout development, reduced the light intensity inside the tree canopy, and increased fruit drop. Fruit yield was higher in the two-split [24.7 metric tonnes (MT) ha?1] and three-split application trees (25.0 MT ha?1) compared to zero application control trees (19.8 MT ha?1) and single application trees (21.0 MT ha?1) in 2010. A single application resulted in soft fruit and slow skin colouration during maturation. Total soluble solids contents were higher in the control and three-split application trees in both years. The three-split application in 2010 increased the estimated production income by approx. 21% compared to the zero application, and by approx. 33% compared to a single application of oil cake. 相似文献
1000.
Chun G. Yoon Song-Bae Kim Tae-Young Kwun Kwang-Wook Jung 《Paddy and Water Environment》2008,6(2):221-227
A pilot study of the natural and ecological wastewater treatment system (NEWS) was performed to treat sewage in decentralized
small rural communities in Korea. The absorbent-biofilter system (ABS) provided secondary level pretreatment and demonstrated
high removal efficiency especially for SS and BOD5 showing 88.5 and 82.9%, respectively. The influent and effluent concentrations of TN were 42.1 and 26.2 mg L−1, respectively, with the removal efficiency of 37.8%. In case of TP, the removal efficiency was 45.1% with the influent and
effluent concentrations of 3.1 and 1.7 mg L−1. The ABS effluent could not meet the effluent standards, and the further treatment was required. The subsequent up- and down-flow
constructed wetland (UDCW) provided further polishing of the ABS effluent and demonstrated effective removal of nutrients
as well as SS and BOD5 with over 70% removal rates. Overall performance of the NEWS, which was composed of ABS and UDCW, demonstrated remarkably
high removal rates for BOD5 (>95.7%), SS (>97.5%), TN (>91.8%) and TP (>90.1%) and met all the effluent standards stably independent of temperature and
influent loading in the experimental range. The UDCW used light and porous granular substrate (∅ 5–10 mm, specific gravity
of 1.2) with large surface area, and clogging problem was not observed during the study period. The system was cost effective
and required minimal maintenance and negligible amount of electricity, and problems associated with noise, odor, files, and
sludge were not observed. Considering characteristics of decentralized wastewater treatment systems, the NEWS system was found
to be a practical alternative and its application is recommended up to 300 m3 day−1. The NEWS system has an economic problem above 300 m3 day−1, because of complicated equipment, higher operation costs, and maintenance specialists. The NEWS system was coast effective
and required minimal maintenance and negligible amount of electricity, and problems associated with noise, odor, files, and
sludge were not observed. 相似文献