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251.
花鲈的胚胎发育和仔鱼发育 总被引:17,自引:0,他引:17
本文描述了温度为12.2-14.0℃、盐度为22‰的天然海水中用捕自浙江省宁海县和奉化市沿海的花鲈进行人工繁殖时,花鲈的胚胎发育和仔鱼发育情况。 相似文献
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Shichang Li Cunzhou Shen Wenyuan Guo Xuefei Zhang Shixin Liu Fengyin Liang Zhongliang Xu Zhong Pei Huacan Song Liqin Qiu Yongcheng Lin Jiyan Pang 《Marine drugs》2013,11(12):5159-5189
Parkinson’s disease (PD) is the second most common neurodegenerative disease affecting people over age 55. Oxidative stress actively participates in the dopaminergic (DA) neuron degeneration of PD. Xyloketals are a series of natural compounds from marine mangrove fungus strain No. 2508 that have been reported to protect against neurotoxicity through their antioxidant properties. However, their protection versus 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity is only modest, and appropriate structural modifications are necessary to discover better candidates for treating PD. In this work, we designed and synthesized 39 novel xyloketal derivatives (1–39) in addition to the previously reported compound, xyloketal B. The neuroprotective activities of all 40 compounds were evaluated in vivo via respiratory burst assays and longevity-extending assays. During the zebrafish respiratory burst assay, compounds 1, 9, 23, 24, 36 and 39 strongly attenuated reactive oxygen species (ROS) generation at 50 μM. In the Caenorhabditis elegans longevity-extending assay, compounds 1, 8, 15, 16 and 36 significantly extended the survival rates (p < 0.005 vs. dimethyl sulfoxide (DMSO)). A total of 15 compounds were tested for the treatment of Parkinson’s disease using the MPP+-induced C. elegans model, and compounds 1 and 8 exhibited the highest activities (p < 0.005 vs. MPP+). In the MPP+-induced C57BL/6 mouse PD model, 40 mg/kg of 1 and 8 protected against MPP+-induced dopaminergic neurodegeneration and increased the number of DA neurons from 53% for the MPP+ group to 78% and 74%, respectively (p < 0.001 vs. MPP+ group). Thus, these derivatives are novel candidates for the treatment of PD. 相似文献
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香猪是贵州东部(中亚热带气候区)闭锁山区的猪种,引入黑龙江(寒温带大陆性季风气候区)饲养,必然经过一段风土驯化过程。几年来,在对香猪进行风土驯化的同时,我们对其在北方的舍饲合理化管理模式亦进行了探索。 相似文献
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Effect of FH535 on in vitro maturation of porcine oocytes by inhibiting WNT signaling pathway
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Meihong Shi Jianyong Cheng Yamei He Zhongliang Jiang Bello M. Bodinga Boyang Liu Huali Chen Qingwang Li 《Animal Science Journal》2018,89(4):631-639
Wingless‐int (WNT) signaling pathway is vital to modulate life processes, including cell fate determination, cell differentiation, cell proliferation, cell apoptosis and embryogenesis. To demonstrate the uncertain effect of the canonical WNT signaling pathway on oocyte maturation, immature porcine oocytes were collected and cultured in vitro with the WNT/β‐catenin inhibitor FH535. The concentrations of FH535 were selected as 0.00, 0.01, 0.10, 1.00 and 10.00 μmol/L. The results showed that the optimum concentration of FH535 on oocyte maturation was 1.00 μmol/L. In this concentration, the proportion of MII oocytes increased (P < 0.05). The rate of cleavage was the same with the control (P > 0.05), while the rate of blastocysts in the 1.00 μmol/L FH535 treated group was higher than that of control (P < 0.01). Additionally, the average number of nuclei in blastocysts raised significantly (P < 0.05). The inhibition of WNT could regulate expression of maturation‐related genes, including Cdc‐2, Bmp‐15, Gdf‐9 and Mos. In the 1.00 μmol/L FH535 treated group, the messenger RNA level of β‐catenin showed no significant change compared to the control (P > 0.05), but the protein abundance was decreased (P < 0.05). This study revealed that the inhibition of FH535 on the WNT signaling pathway could promote the maturation of porcine oocytes and altered gene expressions in vitro. 相似文献
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Most plant growth regulators available are synthesized and tend to be dangerous if used inappropriately.Emistim C AS is a natural plant growth regulator,with less side-effect.The research performed an assessment on Emistim C AS application in watermelon cultivation in a greenhouse.The results showed that 0.11% Emistim C AS increased reducing sugar by 15.49%,soluble solid by 13.7%,Vc content by 3.72%,titratable acid by 18.1%,and yield per hectare by 18.01%,so that watermelon quality and yield were both improved.Emistim C AS can be widely promoted in watermelon cultivation in future. 相似文献
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目的 观察养肺消积分期疗法对晚期(IIIb-IV期)非小细胞肺癌患者的临床疗效及生存的影响。方法 采用队列研究,选取符合入组标准非小细胞肺癌患者156例,其中综合治疗组82例,单纯西医组74例,综合治疗组在西医规范化疗的基础上采用养肺消积分期疗法按阶段治疗,以中位无疾病进展时间(M-PFS)、中位生存期(MST)为主要观察指标,中医临床症状积分变化、肿瘤控制率(DCR)、不良反应等为次要观察指标。结果 综合治疗组第1年、第2年总生存率分别较单纯西医组提高了23.9%、14.6%(P<0.05);与单纯西医组比较,综合治疗组无疾病进展时间、中位生存期均提高了3个月(P<0.01);综合治疗组瘤体控制率比单纯西医组提高13.2%(P<0.05)。结论 养肺消积分期疗法联合西医治疗能够提高晚期非小细胞肺癌患者的总生存期,延长中位无疾病进展时间、中位生存期;同时,可以改善患者中医临床症状积分,增加肿瘤控制率,不良反应小,具有增效减毒作用。 相似文献