Fungitoxicity of 5-aminoisoxazole-4-thiocyanate derivatives

3-Methyl-5-(acyl/alkyl)aminoisoxazole-4-thiocyanates were prepared by rhodanation of N-acyl/alkyl-3-methyl-5-isoxazolamines. These products were tested for antifungal activity against a series of phytopathogenic fungi of different taxonomic classes. Some of the compounds showed interesting in-vitro activity. The more active compound in the in-vitro test displayed a moderate preventive activity against Plasmopara viticola, Alternaria solani and Pyricularia recondita.     

Synthesis and in-vitro antifungal activity of 6-trifluoromethyipyrazolo[3,4-6d]pyrimidin-4(5H)-thiones

Twelve 6-trifluoromethylpyrazolo[3,4-d]pyrimidin-4(5H)-thiones were prepared by the reaction between 4-thiocarbamoyl-5-aminopyrazoles and trifluoroacetic anhydride. They were tested in vitro for antifungal activity against a series of phytopathogenic fungi of different taxonomic classes. The EC50 and MIC values of four compounds were comparable or inferior to those of reference commercial fungicides in controlling Sclerotinia minor, Corticium solani and Phytium ultimum.     

Chemical composition and antimicrobial activity of Momordica charantia seed essential oil

The essential oil obtained from the seeds of Momordica charantia was analyzed by GC/MS. Twenty-five components, representing 90.9% of the oil, were identified. The main constituents were trans-nerolidol, apiole, cis-dihydrocarveol and germacrene D. Furthermore, the oil was tested for its antibacterial and antifungal activities. Staphylococcus aureus was found to be the most sensitive microorganism with MIC values <500 microg/ml.     

A new acylated quercetin glycoside and other secondary metabolites from Helleborus foetidus

A new acylated flavonol glycoside, quercetin 3-O-(2-trans-caffeoyl)-alpha-L-arabinopyranosyl-(1-->2)-beta-D-glucopyranoside (1), together with the known 25R,26-[(beta-D-glucopyranosyl)oxy]-22alpha-hydroxy-5beta-furostan-3-beta-yl O-alpha-l-rhamnopyranosyl-(1-->4)-beta-D-glucopyranoside (2), anemonin (3), beta-D-glucosyl-p-hydroxyphenylethyl alcohol (4), and 1-beta-O-caffeoyl-D-glucose (5) were isolated from Helleborus foetidus leaves and identified on the basis of detailed spectral analysis.     

Neuropharmacology of the essential oil of bergamot

Bergamot (Citrus bergamia, Risso) is a fruit most knowledgeable for its essential oil (BEO) used in aromatherapy to minimize symptoms of stress-induced anxiety and mild mood disorders and cancer pain though the rational basis for such applications awaits to be discovered. The behavioural and EEG spectrum power effects of BEO correlate well with its exocytotic and carrier-mediated release of discrete amino acids endowed with neurotransmitter function in the mammalian hippocampus supporting the deduction that BEO is able to interfere with normal and pathological synaptic plasticity. The observed neuroprotection in the course of experimental brain ischemia and pain does support this view. In conclusion, the data yielded so far contribute to our understanding of the mode of action of this phytocomplex on nerve tissue under normal and pathological experimental conditions and provide a rational basis for the practical use of BEO in complementary medicine. The opening of a wide venue for future research and translation into clinical settings is also envisaged.     

High-Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry (HPLC-ESI-MSn) Analysis and Bioactivity Useful for Prevention of “Diabesity” of Allium commutatum Guss

Plant Foods for Human Nutrition - This study aimed at evaluating and comparing the chemical profile obtained by HPLC-ESI-MSn analysis, the inhibitory activity of enzymes linked to obesity...     

The effect of recumbency and hindlimb position on the lumbosacral interlaminar distance in dogs: a cadaveric computed tomography study

Objective

To examine the effect of sternal or lateral recumbency, with or without cranial extension of the hindlimbs, on the distance between the dorsal lumbosacral laminae in dogs.

Adenocarcinoma of the disseminated prostate in a cat

An adenocarcinoma of the disseminated prostate gland with pulmonary, myocardial and renal metastases is described in a 12-year-old, neutered male European cat. Histologically, the tumour was localised in the spongy layer of the prostatic urethra and showed an epithelial alveolar pattern. Considering the anatomic, microscopic and immunohistochemical findings, the tumour was diagnosed as an adenocarcinoma of the disseminated prostate gland. To our knowledge this is the first report of adenocarcinoma of the disseminated prostate gland in a cat.     

Fungitoxicity of 6H-pyrazolo[3,4-c][l,2,5]thiadiazine-2,2-dioxides

A base-promoted cyclisation of 4-nitroso-5-benzylsulphonamidopyrazoles (VII) afforded 6 H -pyrazolo[3,4-c][1,2,5]thiadiazine-2,2-dioxides (VIII). They were tested in vitro for antifungal activity against a series of phytopathogenic fungi of different taxonomic classes. Five of the compounds had noteworthy activity; in particular 6H-3-phenyl-5-methyl-7–(3,4-dichlorophenyl) pyrazolo[3,4-c][1,2,5]thiadiazine-2,2-dioxide (VIIIc) at the concentration of 200 mg litre^?1 completely inhibited the growth of Pythium ultimum, Corticium solani and Sclerotinia minor.