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101.
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice 总被引:26,自引:0,他引:26
S L Hofmann D W Russell M S Brown J L Goldstein R E Hammer 《Science (New York, N.Y.)》1988,239(4845):1277-1281
A complementary DNA encoding the human low density lipoprotein (LDL) receptor under control of the mouse metallothionein-I promoter was injected into fertilized mouse eggs, and a strain of mice expressing high levels of LDL receptors was established. After administration of cadmium, these mice cleared intravenously injected 125I-labeled LDL from blood eight to ten times more rapidly than did normal mice. The plasma concentrations of apoproteins B-100 and E, the two ligands for the LDL receptor, declined by more than 90 percent after cadmium treatment, but the concentration of another apoprotein, A-I, was unaffected. Therefore, overexpression of an endocytotic receptor can dramatically lower the ambient concentration of its ligand in vivo. 相似文献
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A mutualistic association between a fungal endophyte and a tropical panic grass allows both organisms to grow at high soil temperatures. We characterized a virus from this fungus that is involved in the mutualistic interaction. Fungal isolates cured of the virus are unable to confer heat tolerance, but heat tolerance is restored after the virus is reintroduced. The virus-infected fungus confers heat tolerance not only to its native monocot host but also to a eudicot host, which suggests that the underlying mechanism involves pathways conserved between these two groups of plants. 相似文献
104.
Russell CA Jones TC Barr IG Cox NJ Garten RJ Gregory V Gust ID Hampson AW Hay AJ Hurt AC de Jong JC Kelso A Klimov AI Kageyama T Komadina N Lapedes AS Lin YP Mosterin A Obuchi M Odagiri T Osterhaus AD Rimmelzwaan GF Shaw MW Skepner E Stohr K Tashiro M Fouchier RA Smith DJ 《Science (New York, N.Y.)》2008,320(5874):340-346
Antigenic and genetic analysis of the hemagglutinin of approximately 13,000 human influenza A (H3N2) viruses from six continents during 2002-2007 revealed that there was continuous circulation in east and Southeast Asia (E-SE Asia) via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A (H3N2) viruses outside E-SE Asia may be forecast each year based on surveillance within E-SE Asia, with consequent improvements to vaccine strain selection. 相似文献
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Clutton-Brock TH Brotherton PN Russell AF O'Riain MJ Gaynor D Kansky R Griffin A Manser M Sharpe L McIlrath GM Small T Moss A Monfort S 《Science (New York, N.Y.)》2001,291(5503):478-481
"Limited control" models of reproductive skew in cooperative societies suggest that the frequency of breeding by subordinates is determined by the outcome of power struggles with dominants. In contrast, "optimal skew" models suggest that dominants have full control of subordinate reproduction and allow subordinates to breed only when this serves to retain subordinates' assistance with rearing dominants' own litters. The results of our 7-year field study of cooperative meerkats, Suricata suricatta, support the predictions of limited control models and provide no indication that dominant females grant reproductive concessions to subordinates to retain their assistance with future breeding attempts. 相似文献
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Russell RJ 《Science (New York, N.Y.)》1963,139(3549):9-15
My fieldwork in various parts of the world leads me to the conclusion that the retreat of cliffy coasts through abrasion and solutional erosion during Recent times has produced a whole complex of forms, including conspicuous benches well above sea level where bedrock conditions are favorable. In addition, flats of other origin are being developed at various levels. Broad exposures of beach rock are a marine phenomenon only in that such exposure is a result of beach recession and of the uncovering of materials that had been cemented, under freshwater conditions, along water tables, in some places 6 or more feet above sea level (24, 25). Contemporary coral and algal flats are forming in some instances several feet above the level of the highest tides. 相似文献