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61.
Thaunat O Granja AG Barral P Filby A Montaner B Collinson L Martinez-Martin N Harwood NE Bruckbauer A Batista FD 《Science (New York, N.Y.)》2012,335(6067):475-479
During the activation of humoral immune responses, B cells acquire antigen for subsequent presentation to cognate T cells. Here we show that after mouse B cells accumulate antigen, it is maintained in a polarized distribution for extended periods in vivo. Using high-throughput imaging flow cytometry, we observed that this polarization is preserved during B cell division, promoting asymmetric antigen segregation among progeny. Antigen inheritance correlates with the ability of progeny to activate T cells: Daughter cells receiving larger antigen stores exhibit a prolonged capacity to present antigen, which renders them more effective in competing for T cell help. The generation of progeny with differential capacities for antigen presentation may have implications for somatic hypermutation and class switching during affinity maturation and as B cells commit to effector cell fates. 相似文献
62.
A yearling Irish Cob stallion was presented to De Morette Equine clinic for severe acute abdominal pain, nonresponsive to analgesics and sedatives. Rectal palpation and a limited transabdominal ultrasonographic examination led to the presumptive diagnosis of a strangulated obstruction of the small intestine. The painful behaviour of the pony did not allow conservative treatment and surgical exploration was denied by the owners for financial considerations. On necropsy, a large cystic mature teratoma was adhered to the ventral body wall, the mesenteric root, omentum and intestines. Teratomas are rare in man and animals, and an extragonadal intraperitoneal location has not previously been reported in the equine species. 相似文献
63.
Friardi Ismed Françoise Lohézic-Le Dévéhat Olivier Delalande Sourisak Sinbandhit Amri Bakhtiar Joël Boustie 《Fitoterapia》2012
The diphenyl ether, lobarin (1) (syn. lobariol carboxylic acid) related to lobaric acid was isolated for the first time as a natural product along with five known compounds from Stereocaulon halei, a fruticose lichen collected in Indonesia. The structure of lobarin was elucidated by spectroscopic data analysis and its most stable conformers were determined by molecular mechanic dynamic calculations. A marked superoxide anion scavenging was found for compound 1 while no cytotoxicity on the B16 murine melanoma and HaCaT human keratinocyte cell lines was observed. 相似文献
64.
Olivier Taugourdeau Jean Dauzat Sébastien Griffon Sylvie Sabatier Yves Caraglio Daniel Barthélémy 《Annals of Forest Science》2012,69(6):713-721
Context
Understanding the effects of exogenous factors on tree development is of major importance in the current context of global change. Assessing the structure development of trees is difficult given that they are large and complex organisms with lifespan of several decades.Aims
We used a retrospective analysis to derive the ontogenetic trends in silver fir development and assess the effects of climate or light environment on tree architecture.Methods
Thanks to the identification of relevant growth markers (bud cataphylls and pseudo-whorl branches), a retrospective analysis allowed to record annual shoot extension and to date them on silver firs of various sizes under different environmental conditions.Results
The length of successive annual shoots located on different axes clearly show gradual trends related to the physiological age of meristems. Within- and between-tree variations are noted due to the plasticity of development and growth induced by light environment and climate.Conclusion
Retrospective analysis is an efficient method for getting information on the history of trees architecture and subsequently to relate it to environmental factors. 相似文献65.
66.
Anne Praud Olivier Gimenez Gina Zanella Nathalie Pozzi Valérie Antras Laurence Meyer Bruno Garin-Bastuji 《Tropical animal health and production》2013,45(4):931-933
Porcine brucellosis due to Brucella suis biovar 1 raises important issues for pig breeders in French Polynesia. In this region, the disease is enzootic, spreads silently and engenders economic losses in infected farms as well as sporadic human cases. While serological tests are essential in surveillance and control programmes of animal diseases, to date none of the available tests have been shown to be reliable enough to be used as a gold standard in routine individual diagnosis of porcine brucellosis. Few studies about the estimation of the sensitivity and the specificity of porcine brucellosis screening tests have been published, none of them dealing with French Polynesia. The studied population included 1,595 pigs from French Polynesia. Five tests were evaluated: Rose Bengal test, fluorescence polarisation assay, indirect ELISA, and two competitive ELISAs (C-ELISA). The sensitivity and the specificity of each test were estimated. C-ELISA2 was the most sensitive test (Se C-ELISA2?=?0.954 [0.889; 0.992] 95 % credibility interval (CrI)) while both C-ELISA and Rose Bengal test (RBT) were the most specific ones (Sp C-ELISA1?=?0.856 [0.806; 0.915] 95 % CrI; Sp C-ELISA2?=?0.849 [0.817; 0.879] 95 % CrI; Sp RBT?=?0.853 [0.812; 0.898] 95 % CrI). 相似文献
67.
Oliver Tendayi Zishiri Schalk Willem Cloete Johannes Jacobus Olivier Kennedy Dzama 《Tropical animal health and production》2013,45(2):517-524
Genetic trends were constructed to monitor the genetic change for subjectively assessed and objectively measured traits using data emanating from complete records from the National Small Stock Improvement Scheme database and performance records accumulated by a single breeder over a period of 24 years. The objectively measured production traits considered were weaning weight, post-weaning weight (PWW), yearling weight, average daily weight gain to weaning (ADGW), average daily weight gain during post-weaning phase (ADGPW) and average daily weight gain up to yearling age. The subjectively assessed traits (scored on a five-point scale) were conformation, fat distribution, size, type and colour. Direct genetic trends for live weight and growth traits (with the exception of ADGPW) were positive. All the objectively measured traits where maternal effects were significant, except PWW, registered small declines in maternal breeding values. The fastest genetic progress was attained by ADGW, which amounted to 0.29 % of the overall phenotypic mean per annum. Conformation and type exhibited positive but slow increments in direct breeding values at an equivalent annual rate amounting to 0.12 and 0.09 % of the overall phenotypic mean, respectively. Size demonstrated a negative genetic trend of ?0.14 % of the overall phenotypic mean per annum. Genetic trends for fat distribution and colour were negligible. It was concluded that breeders should focus more on the performance recording of objective traits as they are likely to respond favourably to selection pressure. 相似文献
68.
Laceby J. Patrick Gellis Allen C. Koiter Alexander J. Blake Will H. Evrard Olivier 《Journal of Soils and Sediments》2019,19(9):3245-3254
Journal of Soils and Sediments - 相似文献
69.
Guyonnet D Chassany O Picard C Guillemin I Meunier J Seignobos E Vigneux M Lassel T Trudeau E 《Public health nutrition》2008,11(11):1163-1172
70.