When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans

Humans, like other animals, alter their behavior depending on whether a threat is close or distant. We investigated spatial imminence of threat by developing an active avoidance paradigm in which volunteers were pursued through a maze by a virtual predator endowed with an ability to chase, capture, and inflict pain. Using functional magnetic resonance imaging, we found that as the virtual predator grew closer, brain activity shifted from the ventromedial prefrontal cortex to the periaqueductal gray. This shift showed maximal expression when a high degree of pain was anticipated. Moreover, imminence-driven periaqueductal gray activity correlated with increased subjective degree of dread and decreased confidence of escape. Our findings cast light on the neural dynamics of threat anticipation and have implications for the neurobiology of human anxiety-related disorders.     

意向性建构原理与读者理论

现象学哲学的“意向性建构”原理的实质意义给与 :主体建构对象就是给与对象意义。这是讲求读者建构 (再创造 )文本意义一路文学理论的哲学基础     

Long-Term Variable Rate Lime and Phosphorus Application for Piedmont No-Till Field Crops

Variable rate (VR) fertilizer application is a paradigm with potential to improve input efficiency and farm profitability. It is widely marketed by commercial applicators in the southeastern US. However, field studies comparing VR with traditional management have not demonstrated consistent, positive results. The objectives of this study were: (1) to determine the soil impact, crop response and economic potential of VR phosphorus (P) and lime application in a North Carolina Piedmont no-till field crop system using intensive soybean [Glycine max (L.) Merr.] production and (2) to economically evaluate alternatives to standard commercial grid soil sampling for directing VR P and lime. A 23-ha long-term no-till field in the SE Piedmont was divided into 0.4ha plots assigned to either VR or uniform P and lime application. Grid soil sampling and VR P and lime application were done prior to four crops over 3 years: full season soybean, wheat (Triticum aestivum L.)–double cropped soybean, and full season soybean. Soil test P, pH and crop yield response to VR P were inconsistent. Soil pH in areas with low pH initially did increase in response to VR lime, but it took two to three applications to bring all of these areas to the target pH. Once VR-liming raised initially low soil pH to levels close to target, yield of soybean, but not wheat, were up to 0.74Mgha^–1 higher than with uniform lime. Even with significantly higher soybean yields associated with VR lime, 3 years of grid sampling and VR application were not profitable compared to uniform application. The results indicated that VR lime could be profitable if the initial grid sampling data were used either for 2 consecutive years, or if it was used to restrict future grid sampling to specific areas requiring further VR lime.     

Biosynthesis of the enediyne antitumor antibiotic C-1027

C-1027 is a potent antitumor agent with a previously undescribed molecular architecture and mode of action. Cloning and characterization of the 85-kilobase C-1027 biosynthesis gene cluster from Streptomyces globisporus revealed (i) an iterative type I polyketide synthase that is distinct from any bacterial polyketide synthases known to date, (ii) a general polyketide pathway for the biosynthesis of both the 9- and 10-membered enediyne antibiotics, and (iii) a convergent biosynthetic strategy for the C-1027 chromophore from four building blocks. Manipulation of genes governing C-1027 biosynthesis allowed us to produce an enediyne compound in a predicted manner.     

桑园小长蝽发生危害规律及防治技术研究

 1998年在云南陆良县首次发现小长蝽［(Nysius ercae(schilling)］危害桑树,有的桑园暴发成灾。经1998～2000年调查研究,小长蝽1年发生1代,以成虫在桑园内外杂草丛中越冬,4月下旬至6月中旬是若虫大量发生时期,此时正值桑树发芽抽条,若虫以刺吸式口器吸食桑芽养份和水份,造成桑芽生长不良,不易展叶,以致枯萎脱落。小长蝽发生危害与气候条件、耕作栽培水平有关清洁田园,冬季提早翻耕桑园,翻耕前喷洒化学农药、深施腐施厩肥,桑芽萌发期(4月上旬)喷药防治等综合措施,能有效的控制其危害。     

气候条件对冬小麦穗粒数的影响研究

长期定位试验研究气候条件对冬小麦穗粒数的影响结果表明 ,冬小麦穗粒数主要受返青后 5日滑动平均气温首次≥ 4℃之日～雌雄蕊原基分化时 (即拔节开始天数 )的影响 ,并受其至挑旗期平均最低气温和至抽穗期日照时数的制约。各因素对冬小麦穗粒数的影响大小依次为天数 >日照时数 >平均最低气温。冬小麦高产栽培还应协调好穗数、穗粒数和千粒重三者之间的关系