全文获取类型
收费全文 | 205篇 |
免费 | 3篇 |
国内免费 | 3篇 |
专业分类
林业 | 13篇 |
农学 | 4篇 |
基础科学 | 1篇 |
37篇 | |
综合类 | 4篇 |
农作物 | 7篇 |
水产渔业 | 11篇 |
畜牧兽医 | 109篇 |
园艺 | 2篇 |
植物保护 | 23篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 8篇 |
2020年 | 4篇 |
2019年 | 3篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 8篇 |
2014年 | 8篇 |
2013年 | 23篇 |
2012年 | 8篇 |
2011年 | 6篇 |
2010年 | 6篇 |
2009年 | 12篇 |
2008年 | 10篇 |
2007年 | 18篇 |
2006年 | 12篇 |
2005年 | 7篇 |
2004年 | 12篇 |
2003年 | 17篇 |
2002年 | 16篇 |
2001年 | 6篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1997年 | 3篇 |
1992年 | 1篇 |
1989年 | 1篇 |
1983年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有211条查询结果,搜索用时 11 毫秒
131.
Uechi M Shimizu A Mizuno M 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2002,64(11):1023-1029
To clarify heart rate modulation by the sympathetic nervous system, dogs with naturally acquired and experimentally induced heart failure were examined. Heart rate and plasma catecholamine concentrations were measured in clinically healthy dogs (control dogs) and dogs with mitral regurgitation (MR) during a resting period, a standing period, a period of standing in a medical examination room (to which the dogs were unaccustomed), a running period, and a period of recovery after running. The heart rate and plasma catecholamine concentration increased in control dogs during the standing period and the medical examination room period, relative to the resting period. However, dogs with MR did not exhibit any clear increase in heart rate or catecholamine concentration under these light stress conditions. Running stress increased plasma catecholamine levels in control dogs; however, dogs with MR did not exhibit any significant changes. Thirty-two dogs with naturally acquired heart disease were classified as grades I to III on the ISACHC scale. The degree of increase in heart rate and plasma catecholamine levels in dogs with naturally acquired heart failure depended on their degree of heart failure. In conclusion, an increased heart rate and an activated sympathetic nervous system were observed, even in mild heart failure. This chronically activated sympathetic activity is expected to increase myocardial oxygen consumption, myocardial hypertrophy, and fibrosis, and to portend a poorer prognosis in heart failure. 相似文献
132.
Yoshikawa Y Morimatsu M Ochiai K Nagano M Yamane Y Tomizawa N Sasaki N Hashizume K 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2005,67(10):1013-1017
Mammary tumors are the most common tumor type in women as well as in female dogs. The BRCA2 gene encodes a large nuclear protein that is involved in DNA repair, and mutations in the human BRCA2 confer an increased risk of female mammary tumors. The BRCA2 protein acts as a tumor suppressor, and inactivation of BRCA2 by loss of heterozygosity is implicated in mammary carcinogenesis. In this study, to establish an appropriate polymorphic marker for loss of heterozygosity analysis of the canine BRCA2, we analyzed the genomic sequences of the exon 27 regions of 30 mammary-tumor-bearing and 21 tumor-free dogs. In addition to 10204ins/delAAA, which is the only polymorphism previously identified for the canine BRCA2 locus, we discovered four novel single nucleotide polymorphisms. The analysis of these five polymorphisms revealed the presence of four allele types. Since 10204ins/delAAA was the most common of the five polymorphisms identified, we developed a PCR-based assay method to assay for this polymorphism. We believe that this method is valuable for loss of heterozygosity analysis of the canine BRCA2 gene in tumor pathogenesis. 相似文献
133.
Keiichi Inoue Yoshinobu Inoue Toshiaki Oe Masami Nishimura 《Animal Science Journal》2021,92(1):e13504
The objective of this study was to estimate variance components related to imprinting for carcass traits and physiochemical characteristics in Japanese Black cattle. The carcass records obtained from 4,220 Japanese Black feedlot cattle included carcass weight (CW), rib eye area (REA), rib thickness, subcutaneous fat thickness, and beef marbling score (BMS), and the physiochemical characteristics were fat, moisture, glycogen per proportion of moisture content, oleic acid, and monounsaturated fatty acids (MUFA). To detect gametic effects, an imprinting model was fitted. High additive heritabilities were estimated for all traits (from 0.516 for glycogen to 0.853 for fat) and were reduced in Mendelian heritability. The range of the differences was from 0.002 (CW) to 0.331 (fat and moisture), and the reductions were due to their imprinting variances. The ratio of the imprinting variance to the total additive genetic variance for REA (0.374), BMS (0.291), fat (0.387), moisture (0.388), and MUFA (0.337) were large (p < 0.05). These imprinting variances were due to the maternal contribution and suggested the existence of maternally expressed genomic imprinting effects on the traits in Japanese Black cattle. Therefore, maternal gametic effects should be considered in breeding programs for Japanese Black cattle. 相似文献
134.
Ishikawa Y Uechi M Hori Y Takashi Ebisawa Yamano S Enomoto Y Jun Ugai 《Journal of Feline Medicine and Surgery》2007,9(1):29-35
In order to evaluate the effect of enalapril on haemodynamics and renal function in a pressure overload model, we prepared eight feline models of left ventricular hypertrophy (LVH) by banding of the aortic arch. The LVH cats were assigned to the placebo group or the enalapril group (0.5 mg/kg, PO, sid) 3 months following surgery, and each received its respective drug for 4 weeks. Each week, blood pressure, angiotensin converting enzyme (ACE) activity in blood, and creatinine clearance were measured, and complete blood count (CBC), biochemical examination of the blood, echocardiography, and chest radiography were carried out. The interventricular septum thickness (IVSd, IVSs), fractional shortening (FS), and ejection fraction (EF) increased significantly in the LVH cats following surgery (P<0.05). There was no significant difference between the placebo group and the enalapril group with respect to general physical parameters, CBC, biochemical parameters and renal function. In the enalapril group, systolic arterial pressure, mean arterial pressure, and ACE activity in blood decreased significantly following administration (P<0.05). In addition, the left ventricular free wall thickness in diastole and IVSd decreased significantly following administration (P<0.05). These results suggest that, in a pressure overload model, enalapril (0.5 mg/kg, sid) inhibits cardiac hypertrophy, reduces blood pressure, and does not adversely affect renal function. 相似文献
135.
Kaori Isobe Tsuneo Ito Shun-ichiro Komatsu Kentaro Asanuma Etsuko Fujii Chie Kato Kenji Adachi Atsuhiko Kato Tetsuro Sugimoto Masami Suzuki 《Journal of toxicologic pathology》2012,25(4):281-285
Increased incidence of adrenal pheochromocytoma is frequently encountered in rat
carcinogenicity studies. In some of the studies, the finding is judged to be due to a
rat-specific mechanism of carcinogenesis caused by a disturbance of calcium homeostasis.
However, direct evidence that the proliferation of chromaffin cells in the adrenal medulla is
induced solely by hypercalcemia is not available. In this study, calcium gluconate was
intravenously infused for 7 days to rat chromaffin cells by a tail cuff method, and cumulative
labeling with bromodeoxyuridine (BrdU) was carried out to evaluate the proliferative activity.
The serum calcium concentration was dose-dependently increased, and a high calcium
concentration was stably sustained from day 2 to 7. In the adrenal medulla, BrdU-positive
chromaffin cells increased in the calcium gluconate-treated animals, and the BrdU-labeling
index increased in a dose-dependent manner. In addition, an increased BrdU-labeling index of
chromaffin cells was shown to correlate with the serum calcium concentration. Our results
demonstrate that hypercalcemia directly enhances the proliferative activity of chromaffin cells
and that the proliferative activity is correlated with the serum calcium concentration. 相似文献
136.
Hori Y Uechi M Kanakubo K Sano T Oyamada T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2006,68(9):979-982
A female golden retriever was referred to assess a history of a palpable abdominal mass. A serum chemistry analysis revealed elevated concentrations of blood urea nitrogen, creatinine, calcium, and parathyroid hormone-related protein (PTH-rP). Exploratory laparotomy revealed an ovoid mass within the right ovary. This mass was removed surgically by performing an ovariohysterectomy. The right ovarian mass was diagnosed as a serous papillary adenocarcinoma. Following surgery, the dog recovered, and the serum calcium and PTH-rP concentrations decreased. Therefore, concentrations of PTH-rP and calcium might be associated with serous papillary adenocarcinomas. Serial evaluation of the serum PTH-rP and calcium was useful for evaluating the prognosis. 相似文献
137.
Osamu Yamato Eun-Og Jo Hye-Sook Chang Hiroyuki Satoh Toru Shoda Reeko Sato Masami Uechi Naomi Kawasaki Yoshihisa Naito Masahiro Yamasaki Yoshimitsu Maede Toshiro Arai 《Journal of veterinary diagnostic investigation》2008,20(1):68-71
Molecular screening of GM1 gangliosidosis in Shiba dogs was carried out in northern Japan using blood smear specimens after prolonged storage. Of 125 specimens obtained from 3 veterinary teaching hospitals for this screening, 68 specimens (54%) were adequate for direct amplification in a polymerase chain reaction (PCR)-based DNA test, and the percentage of adequacy was different at each hospital (34%, 73%, and 100%), suggesting that the amount of blood on the smear and the storage condition of specimens may affect adequacy. Of the 68 dogs examined, 2 dogs (2.9%) were heterozygous carriers for this disease and the other dogs were all genotypically normal. The results suggest blood smear specimens can be useful for PCR testing after prolonged storage provided specimens contain a generous amount of blood and have been adequately stored. The study also suggests that GM1 gangliosidosis may be widely prevalent in the Shiba dog population in northern Japan. 相似文献
138.
Oshima M Gu Y Tsukada S 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2003,65(10):1145-1146
The effects of two Peruvian folk medicines, Lepidium meyenii Walp and Jatropha macrantha, on mouse sex steroid hormones and embryo implantation were investigated. Progesterone levels increased significantly in mice that received L. meyenii Walp, while testosterone levels increased significantly in mice that received L. meyenii Walp as well as in those that received both L. meyenii Walp and J. macrantha. However, there were no marked changes in blood levels of estradiol-17beta or the rate of embryo implantation. 相似文献
139.
Kobayashi Y Eda H Kajino E Tate Y Hiruma M Akie Y Saito A Kadota T 《Journal of toxicologic pathology》2010,23(3):147-149
At necropsy, a white nodule (about 5 × 3 mm in size) was observed in the right submandibular gland of a 10-week-old female GALAS rat. Histopathologically, oval to spindle-shaped and pale basophilic tumor cells proliferated closely, and formed variably sized foci. The nodule partially spread into or invaded the surrounding normal tissue, and necrotic foci were recognized in the tumor. Immunohistochemically, the nuclei of the tumor cells showed a diffusely positive reaction for p63, and the cytoplasm showed a diffusely positive reaction for cytokeratin and negative reaction for αSMA, vimentin, desmin and S-100. Many tumor cells were positive for PCNA. Ultrastructurally, the tumor cells contained many tonofilaments in the cytoplasm and a few desmosomes at the intercellular portion. Based on these findings, the tumor was diagnosed as a basal cell carcinoma originating from the duct in the rat submandibular gland. 相似文献
140.
Shugo Suzuki Aya Naiki-Ito Toshiya Kuno Wanisa Punfa Ne Long Hiroyuki Kato Shingo Inaguma Masami Komiya Tomoyuki Shirai Satoru Takahashi 《Journal of toxicologic pathology》2015,28(1):21-26
We previously established 3 cell lines (PLS10, PLS20 and PLS30) from a chemically-induced prostate carcinoma in F344 rats, and demonstrated high potential for metastasis in nude mice. In the present study, we investigated the feasibility of establishing an orthotopic model using the 3 rat prostate cancer cell lines in immunocompetent rats with the aim of resolving species-mismatch problems and defects of immune systems. The PLS10, PLS20 and PLS30 cell lines were injected into the ventral prostates of 6-week-old rats, which were then sacrificed at experimental weeks 4 and 8. Tumor mass formation was found in rats with PLS10, but not in those with PLS20 or PLS30. Additionally, metastatic carcinomas could be detected in lymph nodes and lungs of PLS10-inoculated rats. Genetic analysis demonstrated K-ras gene mutations in PLS10 and PLS20, but not in PLS30 cells. There were no mutations in p53 and KLF6. In conclusion, we established a syngeneic orthotopic model for prostate cancer in immunocompetent rats simulating human castration-resistant prostate cancer (CRPC), which should prove useful for development and validation of therapeutic agents, especially with immunotherapy. 相似文献