Relationship between airway inflammation and pulmonary arterial remodeling in rats with chronic bronchitis and emphysema

AIM:To study the effects of airway and pulmonary inflammation on pulmonary arterial remodeling in rats with chronic bronchitis (CB) and emphysema.METHODS:Twenty-four male Wistar rats were divided into three groups (n=8): Group A: four-weeks CB and emphysema;Group B: six-weeks CB and emphysema group;Group C: normal control.The rat model of CB and emphysema was established by intratracheal instillation of lipopolysaccharide (LPS) and daily exposure to cigarette smog.The arterial blood gas analysis,pulmonary hemodynamics changes and cell counts in bronchoalveolar lavage fluid (BALF) were measured.The pathomorphological changes of airway inflammation,alveoli destruction and pulmonary arterial remodeling were observed by HE straining and triple straining.RESULTS:(1) The characteristic pathological changes of CB and emphysema were observed in group A and B.Neutrophils were the main cells infiltrated into the walls of airway in group A.Lymphocytes and macrophages were the main cells in group B.(2) Right ventricular systolic pressure (RVSP),mean pulmonary arterial pressure (mPAP),the ratio of the weight of right ventricle/left ventricle and septum (RV/LV+S) in group A and B were significantly higher than those in group C (P<0.05).The amount of muscular artery (MA) in group A and B were significantly higher than that in group C (P<0.05).(3) In group A and B,the levels of MA,RVSP,mPAP and RV/LV+S was correlated positively with the average alveolar area,the total cell counts and differential cell counts of neutrophils,lymphocytes and macrophages in BALF,and the level of infiltration into the walls of airway,respectively (P<0.05).The positive correlation was observed with the percentage of neutrophils,lymphocytes and macrophages between group A and B (P<0.05).The amounts of MA were also correlated positively with RVSP,mPAP and RV/LV+S (P<0.05).CONCLUSIONS:(1) The pulmonary artery hypertension,the right ventricular hypertrophy and the pulmonary arterial remodeling appeared before hypoxia.These may be related with the degree of the pulmonary inflammation.(2) The characteristic of pulmonary arterial remodeling was small artery organization,and correlated positively with the changes of hemodynamics.     

河北省中国荷斯坦牛产奶和体型性状遗传参数分析

旨在探究河北省中国荷斯坦牛产奶和体型性状的遗传参数,为育种提供参考.本研究收集了2012-2018年河北省133个牛场8 891头中国荷斯坦母牛第一胎次的3个产奶性状记录(产奶量、乳脂率和乳蛋白率)和26个体型性状记录,利用DMU软件,以场年季、产犊月龄、鉴定年季和鉴定员效应为固定效应,以个体的加性遗传效应为随机效应,...     

农用履带车辆差速转向性能的理论研究

文章设计了履带车辆的液压机械双流驱动系统,对系统中起功率汇流的动力差速转向机构进行参数设计的基础上,理论分析了动力差速转向机构的动力输入和输出之间的转速和扭矩关系,获得了采用该转向机构的履带车辆的理论转向半径和理论最小周转向时间,并通过样机实验获得了实际转向半径和实际最小周转向时间,进行了比较,可用于指导液压机械双流驱动系统的研究     

广西玉米种质资源的特征特性及利用评价

1963~2000年间,广西共收集、保存玉米种质资源1575份,其中广西地方农家种1217份,外省品种5份,国外品种93份,国外自交系249份,国内自交系11份。性状鉴定结果表明:广西玉米种质资源各性状的表现差异较大,生育期春播71~145d,秋播68~111d;株高78~293cm,穗位高17~191cm,穗长6.3~21.5cm,穗粗1.7~5.3cm,穗行数8~24行;果穗多为锥形,粒型以硬粒为主,粒色以白、黄为主,千粒重50~460g。对489份地方种质资源进行籽粒品质分析,结果表明:蛋白质含量9.08%~14.99%,脂肪含量3.22%~7.35%,氨基酸含量0.25%~0.40%。利用广西玉米种质资源培育出的都安2号、多苞玉米30号、墨白玉米、苏湾1号、墨黄9号以及新近育成的糯玉米品种玉美头601、玉美头602等,对广西玉米生产起到了非常重要的作用。今后应继续做好广西玉米种质资源的收集和保存工作,为进一步丰富玉米育种基础提供坚实的物质保障。     

教师专业成长不可缺少的环节：个人课题研究

个人课题的研究在教师专业成长过程中,发挥着重要的作用和影响。在个人课题的研究中,表现出有鲜明的特征、清晰的途径、重要的作用,这些方面对教师专业成长都有一定的积极的促进和影响。     

热带农业科技国际合作项目评价体系初探

从国际科技合作项目的特点出发,探讨提出热带农业科技国际合作项目评价体系的雏形,并对评价体系的项目前评价、项目中评价及项目后评价3个阶段的评价指标加以充实,为热带农业科技国际合作项目的科学、规范管理提供参考依据。     

产量和株型性状良好的抗晚斑病花生新种质创制

花生晚斑病抗性常与不良的产量和株型性状相连锁,为发现更多综合性状优良的抗晚斑病品种,以感病亲本中花5号和抗病亲本ICGV 86699及其杂交构建的重组自交系群体（recombined inbreed lines, RIL）为材料,进行晚斑病抗性、产量和株型相关性状的调查,以筛选综合性状优良的抗病新种质。结果表明,4个环境下共发现18个稳定高抗和26个稳定中抗晚斑病的家系;在两个环境中对百果重和单株结果数进行考察,筛选出38个百果重（≥180.0 g）和单株果数（≥20.0个）都比较大的家系;同样,在两个环境中筛选出主茎高（30～60 cm）和总分枝数（≤20.0个）适中的家系54个。综合分析晚斑病病害等级、产量和株型相关性状,共鉴定出4份产量和株型相关性状优良的抗晚斑病新种质,其中1份高抗晚斑病,3份为中抗晚斑病。该研究结果为培育综合性状优良的抗晚斑病花生品种奠定了理论和材料基础。     

纹缟虾虎鱼精子的主要生物学特性

选取健康成熟的纹缟虾虎鱼(Tridentiger trigonocephalus)进行人工采精,设定不同的盐度和温度梯度,观察其对精子活力及寿命的影响.测定了精子的大小、密度,并观察了精子的超微结构.结果表明,随着盐度和温度的上升,精子的活力和寿命都先增加后降低,在盐度5和温度19 ℃时,精子的活力和寿命分别达到最高.测得精子密度为(1.73×109±0.08×109)/mL,细胞核长径为(0.98±0.12)μm,短径为(0.81±0.08)μm,鞭毛的长度为(7.28±1.06) μm.电镜结果表明:纹缟虾虎鱼精子由头部和尾部(鞭毛)二部分组成,头部的细胞核近圆形,内有核空泡.精子细胞质膜与核膜间有较大间隙,两者之间分布有细胞质和线粒体.中心粒复合体位于植入窝中,由近端中心粒和基体两部分组成.袖套位于核后端,呈一筒状,两侧不对称,袖套腔较为狭窄,两侧分布有线粒体和少量囊泡.鞭毛的核心结构是轴丝,轴丝为典型的"9+2"结构,从轴丝的横切面观察到轴丝外面的质膜呈不规则分布.     

儒家思想对艾兹拉·庞德的政治经济思想影响

儒家思想作为庞德思想体系的重要组成部分,对庞德政治经济思想的形成和完善起了重要的作用。然而,由于文化差异等原因,中西方的庞德研究者长期以来一直都仅仅侧重于研究其中的一面。鉴于此,试图从政治和经济两个方面来探讨儒家思想对庞德政治经济思想的影响。     

Effect of Dietary Supplementation with Hydrolyzed Wheat Gluten on Growth Performance,Cell Immunity and Serum Biochemical Indices of Weaned Piglets （Sus scrofa）

To investigate the effects of dietary supplementation with hydrolyzed wheat gluten (HWG) on growth performance, cell immunity and serum biochemical indices of weaned piglets, 160 crossed (Large White×Landrace) and weaned piglets were randomly divided into 4 treatments with 4 replicates of 10 piglets each. The piglets in each treatment were fed an experimental diet containing either 0 g kg-1 HWG (control group), 30 g kg-1 HWG (3% HWG group), 50 g kg-1 HWG (5% HWG group), or 2.5 g kg-1 glycyl-L-glutamine (0.25% Gly-Gln group). The results showed that the diarrhea rates in 3% HWG and 5% HWG groups were significantly lower than in control group from d 1 to 14 (P＜0.05), while the average daily gain (ADG) in each of two groups was increased (P＞0.05). When compared with control group, dietary supplementation with 3% HWG increased the ratio of CD4+:CD8+ and the ratio of serum albumin and globulin concentrations (A:G) on d 14 and 28, as well as the proliferation of T- and B-lymphocytes (P＞0.05) on d 28. In addition, on d 14 and 28, the A:G ratio in 5% HWG group was significantly higher than in control group (P＜0.05), while the ratio of CD4+:CD8+ increased slightly (P＞0.05). Interestingly, 0.25% Gly-Gln group had higher proportion of CD3+ (P＞0.05) and CD4+ (P＜0.05) on d 14 than control group, but growth performances of 0.25% Gly-Gln group were negatively affected at all experiment stages. These results suggested that HWG might improve the growth performance of piglets by strengthening cell immunity and decreasing the occurrence of diarrhea during the prophase after weaning.