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51.
AMY K. LEBLANC BJOERN W. JAKOBY DAVID W. TOWNSEND GREGORY B. DANIEL 《Veterinary radiology & ultrasound》2009,50(2):215-223
Positron Emission Tomography (PET) using the glucose analog 2-deoxy-2-[18 F]fluoro- d -glucose (18 FDG) is a common imaging modality for diagnosis and management of many human malignancies. We evaluated 18 FDG-PET in dogs with either multicentric lymphoma (LSA) or cutaneous mast cell tumor (MCT). A prototype large field-of-view PET scanner was used to collect whole-body images in nine dogs with LSA or MCT. Both tumors were characterized by avidity for 18 FDG. In dogs with LSA, 18 FDG-PET correctly identified involvement of superficial and internal lymph nodes, liver, and spleen. Repeated PET scans after induction chemotherapy demonstrated resolution of abnormal 18 FDG uptake within these sites. In dogs with MCT, 18 FDG-PET correctly identified MCT metastasis to regional lymph nodes in all dogs in which this was suspected or confirmed with cytology or biopsy before the PET scan. In two dogs, additional sites of mast cell disease were identified with 18 FDG-PET that were undetected on physical examination and/or regional lymph node cytology. 18 FDG-PET holds promise as a whole-body staging method for canine LSA and MCT. 相似文献
52.
GREGORY S. MARSOLAIS DVM MS Diplomate ACVS JEFFREY N. PECK DVM Diplomate ACVS CLIFFORD BERRY DVM Diplomate ACVR ANN JOHNSON DVM MS Diplomate ACVS 《Veterinary surgery : VS》2009,38(6):677-680
Objective— To document the prevalence of femoral medullary infarction associated with the Zurich Cementless Total Hip Replacement (ZCTHR) system in dogs.
Study Design— Case series.
Animals— Dogs (n=35) with 41 ZCTHR implants.
Methods— Medical records (February 1999–December 2002) were reviewed for dogs that had ZCTHR and at least 1 year follow-up with radiographic evaluation. Thirty-five dogs (41 ZCTHR) met the inclusion criteria. Femoral morphologic data, implant to bone relationships, and medullary infarcts were recorded. Data were analyzed for associations between infarct occurrence and morphologic details and dog characteristics.
Results— Eight of 41 femurs had radiographic evidence of infarcts (19.5%). Dogs with infarcts were significantly younger (mean [±SD] age, 18.5±5.2 months) compared with those without infarction (mean age, 44.4±5.6months; P =.027). None of the other variables were significantly different between dogs with and without infarcts. Three femurs with infarcts ultimately developed stem loosening.
Conclusion— A higher prevalence of femoral medullary infarcts was identified with ZCTHR compared with incidence reported for other total hip systems. Younger dogs were more likely to develop infarction.
Clinical Relevance— Femoral infarction appears to be associated with stem loosening. Adjustments in surgical technique or delaying surgery beyond 18 months of age may reduce incidence of infarction but needs further evaluation. 相似文献
Study Design— Case series.
Animals— Dogs (n=35) with 41 ZCTHR implants.
Methods— Medical records (February 1999–December 2002) were reviewed for dogs that had ZCTHR and at least 1 year follow-up with radiographic evaluation. Thirty-five dogs (41 ZCTHR) met the inclusion criteria. Femoral morphologic data, implant to bone relationships, and medullary infarcts were recorded. Data were analyzed for associations between infarct occurrence and morphologic details and dog characteristics.
Results— Eight of 41 femurs had radiographic evidence of infarcts (19.5%). Dogs with infarcts were significantly younger (mean [±SD] age, 18.5±5.2 months) compared with those without infarction (mean age, 44.4±5.6months; P =.027). None of the other variables were significantly different between dogs with and without infarcts. Three femurs with infarcts ultimately developed stem loosening.
Conclusion— A higher prevalence of femoral medullary infarcts was identified with ZCTHR compared with incidence reported for other total hip systems. Younger dogs were more likely to develop infarction.
Clinical Relevance— Femoral infarction appears to be associated with stem loosening. Adjustments in surgical technique or delaying surgery beyond 18 months of age may reduce incidence of infarction but needs further evaluation. 相似文献
53.
LILLIAN R. ARONSON VMD REYNALDO C. GACAD MD KRISTINE KAMINSKY-RUSS MS CLARE R. GREGORY DVM Dipiomate ACVS KEVIN D. MULLEN MB FRCPI 《Veterinary surgery : VS》1997,26(3):189-194
Objective- The purpose of this study was to determine whether an endogenous benzodiazepine receptor ligand (EBZ) was present in the arterial and portal blood of dogs with congenital portosystemic shunts (CPSS).
Study Design- The presence or absence of an EBZ was determined by the collection of systemic and portal blood from dogs with CPSS.
Animals- Fifteen client-owned dogs with a confirmed CPSS. All dogs had historical signs compatible with hepatic encephalopathy. Eight healthy dogs were used as controls.
Methods- In all dogs, systemic blood samples were collected after they were anesthetized. Portal blood samples were collected intraoperatively. EBZ was measured by radioreceptor assay.
Results- In 10 of 15 dogs, the portal blood concentration of EBZ was significantly elevated compared with normal dogs (mean, 13.2 ±18.55 ng/mL). Five dogs had elevated systemic blood EBZ levels (mean, 8.2 ±16.08 ng/mL). Eleven of 15 dogs had a higher portal than systemic blood concentration of EBZ. In contrast, control dogs had extremely low EBZ concentrations detected in their portal blood (mean, 0.16 ±0.3 ng/mL) and systemic blood (0 ng/mL). The mean portal and systemic blood concentrations in dogs with CPSS were significantly greater than in control dogs ( P <.05).
Conclusions- Elevated blood levels of EBZ were found in dogs with CPSS. The portosystemic gradient noted in 11 dogs suggests the gastrointestinal tract as a possible source for the endogenous ligand.
Clinical Relevance- Generalized motor seizures have been reported in dogs after surgical correction of CPSS. If the presence of a CPSS results in stimulation of brain receptors for benzodiazepines, post-CPSS ligation seizures may result from a withdrawal of EBZ after ligation of the portosystemic shunt. 相似文献
Study Design- The presence or absence of an EBZ was determined by the collection of systemic and portal blood from dogs with CPSS.
Animals- Fifteen client-owned dogs with a confirmed CPSS. All dogs had historical signs compatible with hepatic encephalopathy. Eight healthy dogs were used as controls.
Methods- In all dogs, systemic blood samples were collected after they were anesthetized. Portal blood samples were collected intraoperatively. EBZ was measured by radioreceptor assay.
Results- In 10 of 15 dogs, the portal blood concentration of EBZ was significantly elevated compared with normal dogs (mean, 13.2 ±18.55 ng/mL). Five dogs had elevated systemic blood EBZ levels (mean, 8.2 ±16.08 ng/mL). Eleven of 15 dogs had a higher portal than systemic blood concentration of EBZ. In contrast, control dogs had extremely low EBZ concentrations detected in their portal blood (mean, 0.16 ±0.3 ng/mL) and systemic blood (0 ng/mL). The mean portal and systemic blood concentrations in dogs with CPSS were significantly greater than in control dogs ( P <.05).
Conclusions- Elevated blood levels of EBZ were found in dogs with CPSS. The portosystemic gradient noted in 11 dogs suggests the gastrointestinal tract as a possible source for the endogenous ligand.
Clinical Relevance- Generalized motor seizures have been reported in dogs after surgical correction of CPSS. If the presence of a CPSS results in stimulation of brain receptors for benzodiazepines, post-CPSS ligation seizures may result from a withdrawal of EBZ after ligation of the portosystemic shunt. 相似文献
54.
LINDA VAN HOOGMOED DVM Diplomate ACVS JACK R. SNYDER DVM PHD Diplomate ACVS GREGORY ROBERTS DVM MS Diplomate ACVR FA YE A. HARMON 《Veterinary surgery : VS》1997,26(6):497-501
Objective —The purpose of this study was to decribe the clinical presentation, diagnostic evaluation, and surgical management of a llama with an ectopic ureter.
Animals or Sample Population —Nine-month-old female llama.
Results —The diagnostic evaluation included the use of computed tomography and an excretory ureterogram to confirm and identify the location of the ectopic ureter. Surgical management involved a unilateral nephrectomy.
Conclusions and Clinical Relevance —Computed tomography is a valuable asset to diagnose the presence and terminal location of an ectopic ureter in llamas, and nephrectomy appears to be a viable procedure to resolve the subsequent urinary incontinence. 相似文献
Animals or Sample Population —Nine-month-old female llama.
Results —The diagnostic evaluation included the use of computed tomography and an excretory ureterogram to confirm and identify the location of the ectopic ureter. Surgical management involved a unilateral nephrectomy.
Conclusions and Clinical Relevance —Computed tomography is a valuable asset to diagnose the presence and terminal location of an ectopic ureter in llamas, and nephrectomy appears to be a viable procedure to resolve the subsequent urinary incontinence. 相似文献
55.
Autonomic and non-autonomic control of cardiovascular function in stress-sensitive pigs 总被引:4,自引:0,他引:4
The T-wave characteristics, heart rate, stroke volume, cardiac output and blood pressure were examined in acidosis-prone Pietrain and acidosis-resistant Gloucester Old Spot pigs, before and after autonomic blockade with propranolol, atropine and phentolamine. Assessments were made at normal arterial blood pH and pCO2, and at either the same age or live weight in the two breeds. T-wave amplitude was influenced by alpha-adrenergic activity in the absence of beta-adrenergic and parasympathetic receptor activation. The initial cardiac output was 25% greater in the Pietrains, and 75% of this breed difference was due to autonomic factors. Myocardial chronotropic responsiveness to noradrenaline was similar in the two breeds. Initial blood pressure was greater in the Gloucester Old Spots because of a non-autonomic factor, and vasopressor responsiveness to noradrenaline was greater in the Gloucester Old Spots. Although acidosis-prone pigs may be afforded some degree of protection from a sympathetic crisis by having a low vasopressor responsiveness to adrenoreceptor stimulation, enhanced catecholamine output is the likely cause of their stress-induced myocardial lesions. A high catecholamine output may also account for the reduced body fatness in this type of pig. 相似文献
56.
DAVID G. WILSON DVM LLEWELYN C. PEYTON DVM MS GREGORY WOLF DVM 《Veterinary surgery : VS》1987,16(2):167-171
Three horses with equine sarcoids were treated with radical surgical excision and immediate split-thickness skin grafts. Graft take ranged from 50 to 100%, and the epithelial coverage attained resulted in an early functional repair. In no instance was there a recurrence of the sarcoid. 相似文献
57.
Serological diagnosis of botulism in dairy cattle 总被引:1,自引:0,他引:1
58.
59.
Evaluation of Effects of Dietary n-6 to n-3 Fatty Acid Ratios on Leukotriene B Synthesis in Dog Skin and Neutrophils 总被引:1,自引:0,他引:1
DANA M. VAUGHN † ‡ GREGORY A. REINHART§ STEVEN F. SWAIM† SUSAN D. LAUTEN† CARL A. GARNER† MARY K. BOUDREAUX| JOE S. SPANO| CHARLES E. HOFFMAN† BRENDA CONNER † 《Veterinary dermatology》1994,5(4):163-173
Résumé— Les effets d'alimentations supplémentées avec des ratios croissants decides gras polyinsaturés n — 6/n — 3 sur la synthèse de leucotriènes B dans la peau du chien et les neutrophiles sont présentés. Trente chien Beagles ont reçu pendant 2 mois avec une alimentation ayant un ratio n —6/n —3 de 28:1. Des aliments expérimentaux contenant des ratios de 5:1, 10:1, 25:1, 50:1 et 100:1 (six chiens par groupe) ont été administrés ensuite pendant 12 semaines. A la fin des deux mois d'alimentation témoin et au bout de 6 et 12 semaines d'alimentation expérimentale, les concentrations de LTB4 et LTB5 dans la peau et les neutrophiles ont été déterminées. Les neutrophiles de chiens ayant mangé des aliments de ratio 5:1 et 10:1 ont synthétisé 30–33 pourcent moins de LTB4 (P <0,05) et 370–500 pourcent plus de LTB5 (P <0,05) à 6 et 12 semaines, mais le relargage d'anions superoxide était inchangé. La peau des chiens stimulée par un lipopolysaccharide a synthétisé 48 à 62 pourcent moins de LTB4 (P < 0,05) et 48 à 79 pourcent moins de LTB5 (P <0,05) à 12 semaines. [Vaughan, D. M., Reinhart, G. A., Swaim, S. F., Lauten, S. D., Garner, C. A., Boudreaux, M. K., Spano, J. S., Hoffman, C. E., Conner, B. Evaluation of effects of dietary n —6 to n — 3 fatty acid ratios on leukotriéne B synthesis in dog skin and neutrophils. (Evaluation de l'effet du ratio d'acides gras n — 6/n — 3 dans l'alimentation sur la synthèse de leucotriènes B dans la peau du chien et les neutrophiles). Resumen— Evaluamos los efectos producidos por el aumento en la proportion de ácidos grasos poli-insatu-rados n-6 a n-3 en la dieta sobre la sintesis de leucotrienos B en la piel del perro y en los neutrófilos. Se administró durante dos meses una dieta con una proporión 28:1 de ácidos grasos n-6 a n-3 a un grupo de treinta Beagles. Se administraron dietas experimentales con proporciones de 5:1, 10:1, 25:1, 50:1 y 100:1 durante 12 semanas (seis perros por grupo). Se cuantificaron los niveles de leucotrienos B4 y B5 en la piel y en los neutrófilos al final de los dos meses de dieta control y a las 6 y 12 semanas de la dieta-tratamiento. Los neutrófilos de perros con dietas 5:1 y 10:1 sintetizaron 30 a 33% menos leucotrieno B4 (P < 0.05) y 370 a 500% más leucotrieno B5 (P <0.05) a las 6 y 12 semanas pero no alteraron la liberación de aniones superóxido durante la espiracion. La piel de perro estimulada con lipopolisacáridos sintetizó de 48 a 62% menos leucotrieno B4 (P < 0.05) y 48 a 79% más leucotrieno B5 (P < 0.05) a las 12 semanas. [Evaluation of effects of dietary n-6 to n-3 fatty acid ratios on leukotriene B synthesis in dog skin and neutrophils (Effecto de la proporción de ácidos grasos n-6 a n-3 en la dieta sobre la sintesis de leucotrienos B en la piel del perro y en los neutrófilos). Abstract— The effects of diets supplemented with increasing ratios of n-6 to n-3 polyunsaturated fatty acids on leukotriene B synthesis in dog skin and neutrophils were evaluated. Thirty Beagles were conditioned for 2 months on a diet with an n-6 to n-3 fatty acid ratio of 28:1. Experimental diets, containing n-6 to n-3 ratios of 5:1, 10:1, 25:1, 50:1 and 100:1 (six dogs/group), were fed for 12 weeks. At the end of the 2 month control diet period, and again at 6 and 12 weeks of treatment feeding, leukotriene B4 and leukotriene B5 were quantitated in skin and neutrophils. Neutrophils from dogs fed the 5:1 and 10:1 diets synthesized 30–33 per cent less leukotriene B4 (P < 0.05) and 370–500 per cent greater leukotriene B5 (P < 0.05) at 6 and 12 weeks, but had no change in the release of superoxide anions during respiratory burst. Lipopolysaccharide-stimu-lated dog skin synthesized 48–62 per cent less leukotriene B4 (P < 0.05) and 48–79 per cent more leukotriene B5 (P <0.05) at 12 weeks. 相似文献
60.