Systems of knowledge as systems of domination: The limitations of established meaning

The hegemony of Western science, inherent in international development projects, often increases the poverty and oppression of Third World women by pre-empting alternative realities. In African and Asian agrarian societies women grow from 60 to 90% of the food (World Bank, 1989); they hold incredible potential to increase food production. Their ability to operate under more marginal conditions than their male counterparts would seem to indicate that they have developed valuable knowledge— knowledge often generated in response to limited access to the more tangible resources offered by development assistance to male farmers. Recognizing the marginalization of women in the Third World, the Women in Development (WID) network was established during the 1970's to produce knowledge about women, fill in the gaps, and set the record straight. But knowledge creation for these purposes leaves underlying paradigms of Western science-based development unquestioned. Research from a feminist standpoint is used to challenge the objectivity and reliability of EuroAmerican development science. To date, WID has documented and analyzed the causes and consequences of Third World women's oppression with no substantial results to end them. Alternatively, feminist research validates women's perceptions of their reality, helping ordinary people to understand the connections between their experiences and broader social, economic, and political struggles. The paper emphasizes research pursued in order to act, closely linking knowing to doing to promote the emancipation of oppressed groups. A feminist standpoint is used to privilege the perspective of rural women in developing countries and ask: “What are the implications of the standard EuroAmerican approach to science for maximizing the potential contributions of rural women to agricultural development?” Some of these implications are illustrated with examples from on-farm research in Nigeria. To some extent, implications can be addressed by constructing meanings to structure a symbolic framework that includes female farmers and other disadvantaged groups.     

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia

Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they arise and function. Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. We identify a cell compartment in leukemic children that can propagate leukemia when transplanted in mice. By studying a monochorionic twin pair, one preleukemic and one with frank leukemia, we establish the lineal relationship between these "cancer-propagating" cells and the preleukemic cell in which the TEL-AML1 fusion first arises or has functional impact. Analysis of TEL-AML1-transduced cord blood cells suggests that TEL-AML1 functions as a first-hit mutation by endowing this preleukemic cell with altered self-renewal and survival properties.