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The relative amounts of autoantibodies against defined nucleosomal proteins present in serums from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and mixed connective tissue disease (MCTD) have been examined by an enzyme-linked immunoassay. Autoantibodies to nucleosomal proteins were detected in 45 percent of the patients with SLE, 18 percent of the MCTD patients, and none of the RA patients. The results suggest that, in SLE, antibodies are formed against a subset of nucleosomes which contain protein HMG-17. 相似文献
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Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon 总被引:37,自引:0,他引:37
O T Preble R J Black R M Friedman J H Klippel J Vilcek 《Science (New York, N.Y.)》1982,216(4544):429-431
A previously undescribed species of human leukocyte, or alpha, interferon is present in the serum of many patients with systemic lupus erythematosus. It was shown to be alpha-interferon by neutralization with specific antiserums, affinity column chromatography, and antiviral activity on bovine cells. However, 23 of 30 interferon samples tested were inactivated by incubation at pH 2, a characteristic of human "immune," or gamma, interferon. Multiple samples of interferon from the same patient had similar biological properties, but samples from different patients were not all identical, suggesting that several variants of this species of human alpha-interferon may exist. 相似文献
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Chandler Tom Richards Anna E. Jenny Bernhard Dickson Fiona Huang Jiawei Klippel Alexander Neylan Michael Wang Florence Prober Suzanne M. 《Landscape Ecology》2022,37(5):1293-1309
Landscape Ecology - Understanding the variability and dynamics of ecosystems, as well as their responses to climate or land use change, is challenging for policy makers and natural resource... 相似文献
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