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排序方式: 共有128条查询结果,搜索用时 15 毫秒
1.
K Uchio-Yamada N Manabe M Yamaguchi N Akashi Y Goto Y Yamamoto A Ogura H Miyamoto 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(11):1171-1178
Fibrotic degeneration was examined in the kidneys of ICR-derived glomerulonephritis (ICGN) mice, a novel inbred mouse line with a hereditary nephrotic syndrome of unknown etiology considered to be a good model of human idiopathic nephrotic syndrome. In the present study, we histochemically revealed changes in accumulation of extracellular matrix (ECM) components and in localization of integrins, cellular receptors for ECM, in the kidneys of ICGN mice with the progression of renal failure. Excessive accumulation of basement membrane (laminin and collagen IV) and interstitial (type III collagen) ECM components were demonstrated in the glomeruli and tubulointerstitum of ICGN mice. Marked deposition of type I collagen and tenascin was seen only in the glomeruli of ICGN mice but not in those of ICR mice as normal controls. Increased expression of integrin alpha1-, alpha2-, alpha5- and beta1-subunits in glomeruli with fibrotic degeneration and abnormal distribution of alpha6-subunit were noted in the kidneys of ICGN mice. Excessive laminin, a ligand of alpha6beta1-integrin, was demonstrated on the tubular basement membrane, but alpha6-subunit diffusely disappeared on the basal side of the tubular epithelial cells. We presumed that abnormal integrin expression in renal tubules causes epithelial cell detachment, and consequently tubular nephropathy, and results in disorder of ECM metabolism causing excessive accumulation of ECM components in the kidneys of ICGN mice. 相似文献
2.
Fujisawa H Suma K Origuchi K Kumagai H Seki T Ariga T 《Journal of agricultural and food chemistry》2008,56(11):4229-4235
This study verifies the instability of garlic ( Allium sativum L.)-derived allyl 2-propenylthiosulfinate (allicin) in various aqueous and ethanolic solutions as well as in vegetable oil through chemical and biological analyses performed simultaneously. Crushed fresh garlic cloves generated antibacterial activity and chemically detectable allicin, a major antibacterial principle, and both declined on a daily basis in aqueous and ethanolic solutions at room temperature, showing biological and chemical half-lives of about 6 and 11 days, respectively. Allicin was more stable in 20% alcohol than in water, but surprisingly unstable in vegetable oil, with an activity half-life 0.8 h, as estimated from its antibacterial activity toward Escherichia coli, and a chemical half-life of 3.1 h, based on chromatographic quantification. In alcoholic and aqueous extracts, the biological half-life of allicin tended to be longer than the chemical one, suggesting the occurrence of bioactive compounds other than allicin in the extracts. 相似文献
3.
Fuminori Kawabata Kana Murayama Yuta Yoshida Ruojun Liang Shotaro Nishimura Shoji Tabata 《The Journal of Poultry Science》2022,59(3):286
The pungency induced by spices and herbs plays an important role in food choice and appetite, and it is suggested that adding spices and herbs to feed as natural alternatives to antibiotics has beneficial effects in poultry farming. However, our knowledge of the chemosensory perception of herbal compounds in chickens is limited. Transient receptor potential ankyrin 1 (TRPA1) is involved in the sensory perception of various herbal compounds. Here, we performed calcium imaging and electrophysiological analyses using cells transiently expressing chicken TRPA1 (cTRPA1) and identified two novel cTRPA1 ligands—eugenol and thymol. In a behavioral assay, chickens responded to cTRPA1 ligands, including eugenol, thymol, cinnamaldehyde, carvacrol, and allyl isothiocyanate. These results provide evidence that chickens have a functional TRPA1 channel and chemosensory perception of various herbal compounds. 相似文献
4.
Kuko Fuke Kana Takeshita Nanako Aoki Toshiyuki Fukuhara Mayumi Egusa Motoichiro Kodama Hiromitsu Moriyama 《Journal of General Plant Pathology》2011,77(4):248-252
Strains of the Japanese pear pathotype of Alternaria alternata were screened for double-stranded RNAs (dsRNAs). Four strains had several dsRNAs; strain N18 was associated with several
dsRNAs and had impaired growth phenotypes such as irregular mycelium and abnormal pigmentation. We isolated dsRNA-cured isolates
from strain N18 by single-conidium isolation. The dsRNA-cured isolates had recovered normal growth and pigmentation. Enlarged
vesicles were observed in mycelial cells of the original dsRNA-carrying N18 strain. DAPI nuclear staining revealed regression
of the nuclei in dsRNA-carrying N18 cells. These results indicate that the dsRNAs might have negative effects, such as apoptosis-like
cell death, on the host fungus. 相似文献
5.
Pine Wilt Disease Caused by the Pine Wood Nematode: The Induced Resistance of Pine Trees by the Avirulent Isolates of Nematode 总被引:6,自引:0,他引:6
Hajime Kosaka Takuya Aikawa Nobuo Ogura Katsuhiro Tabata Tomoya Kiyohara 《European journal of plant pathology / European Foundation for Plant Pathology》2001,107(7):667-675
Since the beginning of the 20th century, pine trees in Japan have been seriously damaged by the pine wilt disease. This disease is caused by the pine wood nematode, Bursaphelenchus xylophilus, which is transmitted by the Japanese pine sawyer, Monochamus alternatus. The control of disease depends to a large extent on chemicals, but the public is now demanding environmentally friendly control methods. The virulence of B. xylophilus varies very widely. Pre-inoculation of young pine trees in a nursery with avirulent B. xylophilus has induced systemic resistance of trees against a subsequent inoculation with virulent B. xylophilus. This induced resistance was considered a hopeful means for developing a biological control for the disease. The induced resistance by the avirulent nematodes was also expressed in mature pine trees in a forest where the disease was naturally epidemic. However, the effects of induced resistance were not satisfactory for practical biological control. Since the inoculation with higher concentrations of the avirulent B. xylophilus induced the resistance more effectively, the pre-inoculation method will need to be improved to develop the biological control. The induced resistance of pine trees by avirulent B. xylophilus should be one of the candidate biological control methods against pine wilt disease. This induced resistance also provides an experimental system to clarify physiological interactions between the nematodes and pine trees. 相似文献
6.
Ichimi Kazuhiko Honda Miyuki Okada Yuka Tsuzuki Kana Yamaguchi Hitomi 《Fisheries Science》2019,85(3):417-427
Fisheries Science - We carried out surveys to clarify how the density (no. of individuals/m2) and condition factor (CF) of Manila clam Ruditapes philippinarum differ between estuarine tidal flats... 相似文献
7.
Kana Yamashita Yasuhiko Hirakawa Hiroshi Nakatani Motoyoshi Ikeda 《Journal of Wood Science》2009,55(3):161-168
The transverse shrinkage variation within trees was examined for five sugi cultivars. The within-tree trends of tangential
shrinkage (α
T) were different by cultivar, whereas radial shrinkage (α
R) increased from pith to bark in most cultivars. The tangential/radial shrinkage ratio (α
T/α
R) decreased from pith to bark in most cultivars, because the radial variation of α
R was larger than that of α
T. The cultivars showed significant differences among cultivars in α
T, α
R, and α
T/α
R, but the difference among cultivars for α
T/α
R was smaller. The relationships between transverse shrinkage and microfi bril angle (MFA), basic density (BD), tree ring parameters,
and modulus of elasticity were examined. The α
T and α
R showed positive relationships with BD, latewood percentage, latewood density, and modulus of elasticity, and negative relationships
with MFA and ring width. The relationships with earlywood density were weak. Sugi exhibited variation in transverse shrinkage
within stem and among cultivars, with the variation affected by MFA, density, and tree ring parameters.
Part of this article was presented at the 56th Annual Meeting of the Japan Wood Research Society, Akita, Japan, August 2006,
and the 57th Annual Meeting of the Japan Wood Research Society, Hiroshima, Japan, August 2007 相似文献
8.
J. Shen Q. Zhao H. Tang F. Zhang Z. Feng T. Okita N. Ogura T. Totsuka 《Water, air, and soil pollution》1995,85(3):1299-1304
During the period from 25 May 1991 to 30 May 1992 the atmospheric concentrations and depositions of oxides of sulfur were continuously measured in a suburban masson pine forest which is currently experiencing severe dieback, in Chongqing, China. The annual mean concentrations of SO2 and particulate SO4 2? were 220 μ g/m3 (77 ppbv) and 32 μ g/m3 respectively. The atmospheric concentrations of these sulfur compounds were high in late autumn and winter. The annual wet and dry depositions of sulfur to the forest as measured by throughfall and stemflow were 93.1 and 46.6 kgSha?1a?1 respectively. These depositions are among the highest level ever reported in the world. Althogh the cause of the dieback of the masson pine trees has not been unequivocally determined, it is probable that the direct impact of SO2 is more likely the cause than acid deposition. 相似文献
9.
Sasakii K Kimura K Kitaguchi Y Onoue T Ogura H Aoyagi Y 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(8):925-927
Changes in ascorbate content in primary cultured rat hepatocytes exposed to oxidative stress derived from water soluble radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were examined. Cells were exposed to 0.05 and 5 mg/ml of AAPH as 'mild' and severe' oxidative stresses, respectively. Lipid peroxidation in hepatocytes was induced by 'severe' oxidative stress, but not by 'mild' oxidative stress. Ascorbate decreased at 6 hr after administration of both mild' and severe' oxidative stresses, and recovered to the control level after a further 6 hr. In cells treated with 'severe oxidative stress, however, total ascorbate (reduced form plus oxidized form) had increased 24 hr after administration. These results indicated that consumption alone did not account for the increase of ascorbate in hepatocytes under oxidative stress. 相似文献
10.
Kana Naito Yasuhiro Ishiga Kazuhiro Toyoda Tomonori Shiraishi Yuki Ichinose 《Journal of General Plant Pathology》2007,73(4):281-285
Flagellin in Pseudomonas syringae is a potent elicitor of defense responses including hypersensitive cell death in dicot plants. The oligopeptides flg22 consisting
of 22 conserved amino acids near the N-terminus of flagellins is reported to induce plant defense responses. Because glycosylation
of the central domain of flagellin affects its elicitor activity, we investigated whether any peptide sequence in addition
to flg22 is required for flagellin-induced hypersensitive reaction. A study of recombinant flagellin polypeptides indicated
that the N-terminal domain including the conserved flg22 is required for flagellin-induced hypersensitive cell death in Arabidopsis thaliana. 相似文献