Bioavailability of iron from four different local food plants in Jordan

The bioavailability of iron from local plants(black cumin seeds, milk thistle seeds, sesame seedsand thyme leaves) was investigated. Apparentabsorption of iron was calculated by subtracting fecal iron(using total collection of feces) from iron intake inSprague-Dawley rats. Two trials of animal feeding wereperformed. Liver and serum concentrations of iron, andserum hemoglobin concentration were taken as responseparameters for the bioavailability. Dry thyme wasparticularly rich in iron (117.2 mg/100 g dry matter)and milk thistle seeds in crude fiber (25 g/100 g drymatter). Rats fed the dry thyme diet or thatsupplemented with 5% egg white died but when the dietwas supplemented with 10% egg white, the animalssurvived. Iron intake and apparent and total ironabsorption were highest for the rats fed the drythyme-egg white diet. Liver weights for the groups fedblack cumin seeds and dry thyme were significantlyhigher (p < 0.05) than those for the groups fed milkthistle and sesame seeds. Liver content of ironwas highest for the animals fed black cumin seeds.Serum iron content increased significantly (p < 0.05)for the animals fed black cumin seeds, and serumhemoglobin concentration increased significantly (p < 0.05) in the groups fed milk thistle seed and blackcumin seed diets, but decreased for the group fed thethyme-egg white diet. It is concluded from this studythat iron was better utilized from black cumin seedsas indicated by liver storage of iron. On the otherhand, thyme had the highest iron absorption but lowestutilization.     

Protein Digestibility using Corrected Amino Acid Score method (PDCAAS) of four types of mushrooms grown in Jordan

This study was conducted to evaluate the protein quality of four types ofedible mushrooms common in Jordan in terms of protein digestibility –corrected amino acid score (PDCAAS), which is a combination of thechemical score of the limiting amino acid multiplied by true digestibility ofthe protein. True protein digestibility values were low (61.4, 73.4, 52.6and 80.5 for Terfezia claveryi, Pleurotus ostreatus, Tricholoma terrum and Agaricus macrosporus, respectively). Based onthe essential amino acids pattern requirements for children, the limitingamino acids in P. ostreatus and A. macrosporus protein weresulphur-containing amino acids with chemical scores of 0.61 and 0.50,respectively. However, lysine was the limiting amino acid in the protein ofT. claveryi and T. terreum with chemical scores of 0.71 and 0.67,respectively, and the PDCAAS was 0.43, 0.45, 0.35 and 0.40 for themushrooms types, respectively. Considering the pattern of essential amino acid requirements of laboratory rats, thesulphur containing amino acids were the limiting amino acids in the proteinof T. claveryi, P. ostreatus, T. terreum and A.macrosporus with chemical scores of 0.56, 0.30, 0.34 and 0.25,respectively. The PDCAAS were 0.34, 0.22, 0.17 and 0.20,respectively. It is concluded that the four mushroom types studied are of lowprotein quality.     

Long term use of hydraulic artificial urethral sphincters in nine dogs from New Zealand with urethral sphincter mechanism incompetence

AIMS: To report on the long-term outcomes of hydraulic artificial urethral sphincter (HAUS) placement for the correction of urethral sphincter mechanism incompetence (USMI) in New Zealand dogs.

METHODS: Retrospective data were obtained from cases of dogs which had a HAUS placed after failed medical and/or surgical management of USMI between August 2012 and November 2016. Owner assessment of urinary incontinence was evaluated by an online survey in May 2017 using a visual analogue scale (0 being normal, 100 being severely affected) for the frequency, volume and severity of any straining to urinate, immediately prior to the placement of the HAUS and at the time of the survey. The number of days between surgery and the completion of survey were recorded.

RESULTS: Seven females and two male dogs, which were all desexed except for one female, were eligible for inclusion in the study. The period of follow-up following HAUS placement ranged from 206–1,685 days. Following HAUS placement, frequency and volume of urinary incontinence decreased for six dogs and were practically unchanged for three dogs. The median frequency score decreased from 70 to 13 and the volume score decreased from 73 to 12. There was no consistent change in the perceived degree of straining to urinate. Complications occurred in three dogs; one required repositioning of a dislodged injection port, one required management for haematuria and a hypoplastic bladder, and one required surgical removal of fibrous tissue around the HAUS cuff.

CONCLUSIONS AND CLINICAL RELEVENCE: HAUS placement was an effective method for the treatment of persistent USMI in most dogs and provided good clinical results based on owner assessment. The technique was associated with few complications and allowed successful long-term control of urinary incontinence without the need for medical management.     

"人、机、料、法、环"与兽药GMP的关系

本文尝试将质量管理学中五要素"人、机、料、法、环"的重要概念引入到兽药GMP管理体系中来,便于记忆和理解,有助于进一步认识、掌握和运行GMP.     

对兽药地方标准清理工作的思考

当前兽药地方标准清理工作已进入攻关阶段,但在清理地方标准的实际工作中尚存在一些问题,笔者分析了这些具体问题,认为在升标工作中,政府应当给予合理的政策扶持,加快地方标准清理工作进度,保护企业利益;企业应当着重做好品种筛选,合理安排临床试验资金投入;企业通过采取联合参与升标方式,减少资金投入;对于移植外省标准,可采取不同措施妥善解决;为保证升标工作顺利进行,农业部和各省兽医行政管理部门应做好升标培训指导工作.     

江苏省兽药科技创新探析

当前兽药生产企业已全面通过GMP验收，兽药科技创新成为后GMP时代企业生存发展的首要任务。在此形势下江苏省提出了“建设兽药强省”工作思路。针对当前江苏乃至全国兽药产业现状进行了调查分析和研究探索，就如何充分利用本省科研优势和GMP建设形成的基础设施优势，在政府投入引导机制、合作创新开发机制和企业内研发机制等方面提出了建设性意见。     

江苏省实施兽药GSP试点工作的基本做法与推进思考

江苏省GSP试点工作通过加强组织领导、广泛宣传推动、强化培训指导和注重检查交流等措施,基本建立了兽药GSP制度的框架,进一步提高和统一了对兽药GSP的认识,提高了试点企业的质量管理水平。但在兽药GSP实施过程中,存在对其重要性认识不足,部分暂行管理办法内容与实际脱节,技术指导力量薄弱等问题。