转变兽药行政审批理念提高兽药行政审批效能

兽药行政审批工作，是法律设定的具有强制力的政府行为，对管理相对人和生产者、畜产品消费者的利益影响重大，处理不好，很容易引发社会矛盾。兽药管理在管理制度、管理内容和管理形式上，与人用药品管理都有很多相似之处，国家食品药品监督管理局腐败案件的发生，给我们敲响了警钟。本文结合近年来兽药管理工作实践，借鉴发达国家的先进管理理念，从树立先进审批理念、严格审批程序和建立完善权力运行机制等3个方面着重阐述了兽药行政审批工作应坚持以科学发展观为指导，转变审批理念，完善审批程序，提高审批效能。     

用免疫抑制小鼠快速培育抗苏拉明伊氏锥虫

将伊氏锥虫克隆ＪＧｍｃ５用环磷酰胺处理的免疫抑制小鼠频繁地连续传代，并予以亚治疗剂量的苏拉明治疗，连续传代１４次，历时８８日，即获得对苏拉明具有高水平抗药性的伊氏锥虫群体。在用免疫活性正常的健康小鼠测定抗药性时，此抗苏拉明锥虫群体仍保持高水平的抗药性，ＣＤ１００＞４００ｍｇ／ｋｇ。在以体外药敏试验测定时，其ＩＣ５０为１２３．２μｇ／ｍｌ。实验结果表明，宿主免疫系统的损害，在实验条件下，可导致伊氏锥虫迅速产生抗药性。在野外条件下，机体免疫系统的损害对锥虫抗药性的产生可能也起一定作用。     

DNA profiling and genetic diversity of Korean soybean (<Emphasis Type="Italic">Glycine max</Emphasis> (L.) Merrill) landraces by SSR markers

Approximately 7,000 accessions of Korean soybean (Glycine max (L.) Merrill) landraces, largely composed of three collections, the Korea Atomic Energy Research Institute’s soybean (KAS), the Korean Crop Experiment Station’s soybean (KLS) and the Korean Agricultural Development and Technology Center’s soybean (KADTC) collections, have been conserved at the Rural Development Administration (RDA) genebank in Korea. The accessions within collections were classified based on their traditional uses such as sauce soybean (SA), sprouted soybean (SP), soybean for cooking with rice (SCR), and OTHERS. A total of 2,758 accessions of Korean soybean landraces were used to profile and to evaluate genetic structure using six SSR loci. A total of 110 alleles were revealed by at the six SSR loci. The number of alleles per SSR locus ranged from 9 to 39 in Satt187 and Satt_074, respectively. The number of alleles ranged from 87 in the KADTC collection to 96 in the KLS collection, and from 63 in the SCR group to 95 in the SP group. Nei’s average genetic diversity ranged from 0.68 to 0.70 across three collections, and 0.64 to 0.69 across the usage groups. The average between-group differentiation (G _st) was 0.9 among collections, and 4.1 among the usage groups. The similar average diversity among three collections implies that the genetic background of the three collections was quite similar or that there were a large number of duplicate accessions in three collections. The selection from the four groups classified based upon usage may be a useful way to select accessions for developing a Korean soybean landrace core collection at the RDA genebank. DNA profile information of accessions will provide indications of redundancies or omissions and aid in managing the soybean collection held at the RDA genebank. The information on diversity analysis could help to enlarge the genetic diversity of materials in breeding programs and could be used to develop a core collection.     

Isotopic composition of nitrogen: implications for the past history of mars' atmosphere

Models are presented for the past history of nitrogen on Mars based on Viking measurements showing that the atmosphere is enriched in (15)N. The enrichment is attributed to selective escape, with fast atoms formed in the exosphere by electron impact dissociation of N(2) and by dissociative recombination of N(2)(+). The initial partial pressure of N(2) should have been at least as large as several millibars and could have been as large as 30 millibars if surface processes were to represent an important sink for atmospheric HNO(2) and HNO(3).     

基于鲁棒自适应控制策略的混合型步进电机低速伺服控制性能

针对混合型步进电机低速运行状态下脉动转矩较大的特点,应用鲁棒自适应控制策略来设计其低速伺服控制器,以实现高精度的跟踪控制性能.首先,根据混合型步进电机转矩形成的机理,揭示了其固有的脉动转矩对低速运动控制产生不利影响的动力学特征,并将它归结为两种结构不确定性,便于控制器的设计;其次,采取标准的自适应控制及其鲁棒化设计思想,借助于μ-修整策略来实现相应的控制律,确保脉动转矩的最大化补偿及伺服系统低速跟踪控制满足高性能的要求;最后对所建立的低速跟踪控制系统的性能进行了试验评估,并与作者前期的工作进行了比较,试验结果验证了其有效性与可行性.     

Effects of Culture Area,Stocking Density,and Shrimp and Fish Polyculture on the Cost Efficiency of Hard Clam,Meretrix meretrix,Culture: A Case Study of Hard Clam Farms in Yunlin,Taiwan

Using the hard clam farms in Yunlin, Taiwan as examples, this study analyzes the effects of culture area, stocking density, and shrimp and fish polyculture on the cost efficiency (CE) of hard clam farming. A data envelopment analysis (DEA) is used to estimate the farms' technical efficiency (TE), allocative efficiency (AE), and CE values. The findings show that the mean TE, AE, and CE values of hard clam farms are 0.74, 0.57, and 0.43, respectively. The TE value is higher than the AE value, which indicates that cost inefficiency is mainly attributable to poor AE. Tobit regression results suggest that there are positive relationships between CE and both culture area and operator experience. Hard clam stocking density and age of the operators have negative effects on CE. Hard clam culture areas larger than 2 ha and a stocking density of 1.1–1.2 million hard clams per hectare have higher CEs than smaller culture areas and smaller or larger stocking densities. The use of sand shrimp, white shrimp, kuruma shrimp, and grass shrimp for polyculture and the use of milkfish and silver sea bream for polyculture are both associated with high CEs.     

Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity

Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus. Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression.     

Imaging doped holes in a cuprate superconductor with high-resolution Compton scattering

The high-temperature superconducting cuprate La(2-x)Sr(x)CuO(4) (LSCO) shows several phases ranging from antiferromagnetic insulator to metal with increasing hole doping. To understand how the nature of the hole state evolves with doping, we have carried out high-resolution Compton scattering measurements at room temperature together with first-principles electronic structure computations on a series of LSCO single crystals in which the hole doping level varies from the underdoped (UD) to the overdoped (OD) regime. Holes in the UD system are found to primarily populate the O 2p(x)/p(y) orbitals. In contrast, the character of holes in the OD system is very different in that these holes mostly enter Cu d orbitals. High-resolution Compton scattering provides a bulk-sensitive method for imaging the orbital character of dopants in complex materials.