Possible adverse reaction to droncit in a miniature poodle

Abstract

Extract

Madam:— The N.Z.V.A. Nominee on the National Hydatids Council, Mr Peter Malone, in his annual report states that he knows of “no professional concerns that would allow certificates to be issued to exempt dogs from dosing with droncit, and on receipt of copies of such certificates will continue to forward them to the Veterinary Council to examine for disciplinary action”. (1 1985. Report of the N.Z.V.A. Nominee on the National Hydatids Council: N.Z.V.A. Annual Report 43–43.  [Google Scholar] In September 1985 I examined a nine year old miniature poodle dog that had been dosed with droncit by a hydatids control officer two hours previously. The dog had collapsed into lateral recumbancy, was pale and cyanotic with a rectal temperature of 37.3°C. Cardiac and thoracic auscultation was normal, and no other abnormal clinical signs were detected. There was no previous history of similar episodes and the dog has been dosed with droncit several times beforehand without problems. The dog was treated with betamethasone and millophylline and made a full recovery within 48 hours.     

Suspected ciliary dysfunction in Chinese Shar Pei pups with pneumonia

Chronic pneumonia was investigated in a litter of young Chinese Shar Pei in which 4 of 6 dogs were affected. Serum immunoglobulin concentrations (IgA, IgG, IgM) determined by radial immunodiffusion varied over time, but were not consistently lower in affected dogs, compared with control dogs. Two dogs that died had hydrocephalus and lymphoid depletion, in addition to severe broncho-pneumonia. Evaluation of ciliary ultrastructure in 2 affected dogs revealed random orientation of adjacent respiratory tract or oviductal cilia and a greater number of microtubular disarrangements, compared with control dogs. In vivo tracheal mucociliary clearance of 99mtechnetium macroaggregated albumin was absent in 1 dog examined. The ciliary abnormalities were suspected to have resulted in an inefficient mucociliary transport system predisposing to the development of pneumonia. Further evaluation of 1 Chinese Shar Pei revealed lymphocyte mitogenesis results that were not consistently less than those of a control dog, normal total hemolytic complement values, and normal blood neutrophil chemotaxis.     

Digestible energy requirements for work and maintenance of horses fed conventional and fat-supplemented diets

A control and a 10% fat-supplemented diet were fed to exercising horses maintained in two different body conditions, during both temperate and hot weather, to determine the efficacy of fat as dietary aid to reduced energy requirements for thermal regulation in exercising horses. Horses were worked 7.2 km daily, 5 d/w, and in each season were fed sufficient energy to maintain constant body weight and body fat content at each assigned level of body condition. In both seasons and in both body conditions, digestible energy intake was lower (P<.01) when the horses were fed the fat-supplemented diet than when fed the control diet. Digestible energy intake was partitioned into requirements for work and maintenance. Since work levels were similar, digestible energy requirements for work were similar when horses were fed both experimental diets. However, the digestible energy requirements for maintenance were significantly lower (P<.01) when the horses were fed the fat-supplemented diet. Thus, it appears that feeding fat to exercising horses reduces the thermal load and resulting digestible energy requirements for maintenance in both temperate and hot weather.     

Growth and feed utilization by yearling horses fed added dietary fat

Twenty-four yearlings were used to evaluate the efficacy of feeding feed-grade fat to growing horses. All horses were started on trial at 13-months-of-age and were fed for 112 days. The experimental diets, containing similar nutrient-to-calorie ratios, were: 1) control (no added fat; 2) 5% added fat and; 3) 10% added fat. There was a trend for yearlings fed the 10% added fat diet to grow faster and eat less feed than those on the control diet. Data from this study indicate that feed-grade fat can be safely fed to growing horses. Feeding fat to yearlings stimulated growth and efficiency of feed utilization initially, but these effects were not maintained as the yearlings grew toward maturity.     

Effect of oral Escherichia coli inoculation on performance of young turkeys

A strain of Escherichia coli isolated from the yolk sac of stunted turkey poults was administered orally to day-old large white poults. Poults were inoculated with either 0.1 ml of sterile broth or 0.1 ml of a 10(-2) dilution of a 24-hr E. coli culture containing 3.4 x 10(8) viable bacteria per ml. Two levels of dietary protein (28 or 22%) were fed from 1 day to 3 weeks of age. Following E. coli inoculation of 3.4 x 10(5) viable bacteria at day one, body weight gain and feed consumption from 0 to 3 weeks of age were numerically increased 4.5 and 2.1%, respectively, and feed efficiency was significantly increased 2.4%. E. coli had a greater effect on performance of poults fed the 28% protein diet than on poults fed the 22% protein diet. Metabolism studies, conducted from 7 to 10 and from 17 to 20 days postinoculation, showed no significant changes in the measurements of nutrient utilization due to E. coli other than a 17% increase in nitrogen retention from 17 to 20 days by those poults fed the 28% protein diet.     

Characterization of changes related to mineral balance and bone metabolism in the young racing Quarter Horse

This study was conducted to determine physiologic responses reflective of bone metabolism during the onset of training and to relate those responses to the mineral requirements of young racehorses. Ten previously untrained Quarter Horse geldings were put into race training. They were fed a diet balanced to meet NRC recommendations for young horses in training. Feed, feces and urine were collected, weighed and analyzed over the experiment to determine mineral balance. Radiographs were taken of the left front leg to determine mineral content of a cross-sectional area of the third metacarpal. Blood samples were taken to determine osteocalcin, parathyroid hormone, 25-hydroxyvitamin D, Ca and inorganic P concentrations. Horses were gentled to ride, trained to gallop on the track and maintained in training for four 28-day periods. Blood serum was collected every 14 day, while radiographs and 72-hr total collections of urine and feces were taken every 28 d. Radiographs demonstrated that mineral content was lowest at day 56 in the dorsal, palmar and medial cortices of the third metacarpal. Urinary Ca declined dramatically from day 0 to day 28, then remained constant to day 56, before decreasing at day 84. Fecal Ca peaked at day 28 and remained elevated above day 0 amounts until day 112. calcium retention was negative at day 0, became slightly positive by day 28 and increased through day 112. Phosphorus and Mg balance remained relatively unchanged throughout the duration of the study. This study demon-strated changes in the mineral content of the third metacarpal and Ca balance during early training and suggests that further studies be performed.