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1.
Krontveit RI Nødtvedt A Sævik BK Ropstad E Skogmo HK Trangerud C 《Preventive veterinary medicine》2010,97(3-4):252-263
The study-objective was to measure the effect of weight and growth related parameters on the risk of development of Canine Hip Dysplasia (CHD). The hypothesis was that heavy and fast growing dogs of large sized breeds were at increased risk of development of CHD compared to lighter and slower growing dogs. A prospective cohort study was conducted among dogs of four large breeds: Newfoundland (NF), Leonberger (LEO), Labrador retriever (LR), and Irish wolfhound (IW). The dogs were privately owned with individualized nutrition and environment, and they were followed from birth and throughout the growth period until the official screening for CHD was performed. The study sample consisted of 501 dogs from 103 litters, with the breed distribution 125 NF, 180 LEO, 133 LR, and 63 IW. Because the dogs were clustered in litters a multivariable random effects logistic regression model was used to assess statistically significant growth-related risk factors for CHD. The estimated incidence risk of CHD was 36% in NF, 25% in LEO, 20% in LR, and 10% in IW. Based upon the final multilevel model it appears that the odds of CHD among both LR and IW (odds ratio (OR) 0.22) are about one-fifth of the odds for NF. The odds for LEO (OR 0.60) are not significantly different from NF. There appeared to be an inverse relationship between body weight at 3 months of age and odds of CHD, with an OR of 0.89 (P=0.044). The degree of clustering at the litter-level was high (22.6%) and highly significant (P<0.001). Findings failed to support the hypothesis that heavy and fast growing dogs from four large sized breeds were at increased risk for development of CHD. There might be other unmeasured environmental risk factors for CHD in this cohort of dogs, although the contribution of the genetic variance to the litter-level clustering also needs further investigation. 相似文献
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Krontveit RI Trangerud C Sævik BK Skogmo HK Nødtvedt A 《Preventive veterinary medicine》2012,103(2-3):219-227
We conducted a prospective cohort study including privately owned dogs from the breeds Newfondland (NF), Labrador Retriever (LR), Leonberger (LEO), and Irish Wolfhound (IW) followed from birth until age 9 yrs. We wanted to investigate whether radiological hip dysplasia status given at approximately age 12-18 mos and other factors during growth influenced development of clinical signs due to hip-joint disease necessitating veterinary consultation. Whether or not such signs occurred due to hip dysplasia or due to secondary or primary DJD could not be distinguished, and we therefore used the term "owner-reported veterinary-diagnosed hip-related clinical signs" ("the event"). The included dogs were followed from birth to the event or until a maximum of 9 yrs of age. Our objectives were to describe breed differences in time to incidence and to evaluate potential risk factors for the time to event. We used Kaplan-Meier curves to describe time to incidence, and potential risk factors were assessed by use of a Cox proportional-hazards model. We enrolled 494 dogs from 103 litters, and 46 dogs were reported as having had the event during the observation period. We observed a significant time-varying effect (TVE): LR and LEO developed clinical signs later in life than NF. If the radiological hip status was either mild, moderate, or severe the hazard of experiencing the event was significantly increased. Access to off-leash exercise at age 12 mos decreased the hazard of the event, and the hazard varied by litter. The findings supported the hypothesis that radiological hip status at screening and exercise conditions during growth influenced the time to incidence of the event and that there were breed differences in time to the event. 相似文献
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J. J. Runge S. P. Kelly T. P. Gregor S. Kotwal G. K. Smith 《The Journal of small animal practice》2010,51(5):264-269
Objective : To determine if age, breed, gender, weight or distraction index (DI) influenced the risk of radiographic osteoarthritis (OA) of canine hip dysplasia (CHD) in four common dog breeds; the American bulldog, Bernese mountain dog, Newfoundland and standard poodle. Materials and Methods : This was a cross sectional prevalence study with 4349 dogs. Canine hips were evaluated using 3 radiographic projections: the hip-extended view, the compression view and the distraction view. The hip-extended view was examined for the presence of OA. The PennHIP distraction view was utilized to calculate the DI. For all breeds, a multiple logistic regression model incorporating age, weight, gender, and DI was created. For each breed, disease-susceptibility curves grouping dogs on the basis of age were constructed. Receiver-operating characteristic (ROC) curves were developed for each breed regardless of age. Results : For all breeds, DI was the most significant risk factor for the development of OA associated with CHD. Weight and age were also significant risk factors in all four breeds, but gender was not. Clinical Significance : Results from this study support previous findings, that irrespective of breed, the probability of radiographic OA increases with hip joint laxity as measured by the DI. Breed-specific differences in this relationship, however, warrant investigation of all breeds affected by CHD to determine inherent dependency of hip OA on joint laxity. Such findings guide veterinarians in helping dog breeders to make evidence-based breeding decisions and in informing dog owners to implement preventative treatments for CHD for dogs found to be at risk. 相似文献
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Background
Prospective studies to document the occurrence of canine diarrhoea and vomiting are relatively scarce in dogs, and the majority of published studies are based on information from clinical records. This study investigates the incidence risk of diarrhoea and vomiting as well as potential risk factors.Methods
A cohort study of 585 privately owned dogs of four breeds: Newfoundland, Labrador retriever, Leonberger, and Irish wolfhound. The owners maintained a continuous log regarding housing, exercise, nutrition, and health of their dogs. Episodes of diarrhoea and vomiting were recorded in a consecutive manner in a booklet. The owners completed the questionnaires and reported information at three, four, six, 12, 18, and 24/25 months of age, called observational ages.Associations with potential risk factors for diarrhoea and vomiting were investigated in separate generalized estimating equation analyses.Results
The incidence of both diarrhoea and vomiting was influenced by breed. Both diarrhoea and vomiting were relatively common in young dogs, occurring most frequently during the first months of life. After three months of age, the odds of diarrhoea were significantly lower when compared to the observational period seven weeks to three months (OR ranging from 0.31 to 0.70 depending on the period). More males than females suffered from diarrhoea (OR = 1.42). The occurrence of diarrhoea was more common in dogs that also experienced episode(s) of vomiting during the study period (OR = 5.43) and vice versa (OR = 5.50). In the majority of dogs episodes of diarrhoea and vomiting did not occur at the same time. Dogs in urban areas had higher odds (OR = 1.88) of getting diarrhoea compared to dogs living in rural areas. The occurrence of both diarrhoea and vomiting demonstrated a seasonal variation with higher incidence during the summer months.Conclusion
Both diarrhoea and vomiting occurred most frequently during the first months of life. The incidence of diarrhoea and vomiting was significantly different between breeds. Diarrhoea occurred more frequently in males and in dogs living in urban areas. Also, a positive association between the occurrence of diarrhoea and vomiting in the same dog was found. 相似文献6.
Sofia Alves‐Pimenta Bruno Colaço Armando M. Fernandes Lio Gonçalves Jorge Colaço Pedro Melo‐Pinto Mário M. Ginja 《Veterinary radiology & ultrasound》2017,58(6):627-633
Elbow joint incongruity is recognized as an important factor in the development, treatment, and prognosis of canine elbow dysplasia. Elbow incongruity has been measured based on radiographic joint space widths, however these values can be affected by the degree of elbow joint flexion. Recent studies have reported radiographic curvature radii as more precise measures of humeroulnar congruity in dogs. The aim of this prospective observational study was to describe radiographic curvature radii measured from flexed and extended elbow radiographs for a sample of dogs representing a medium breed (Portuguese Pointing Dog) and a large breed (Estrela Mountain Dog). The curvature radii from the ulnar trochlear notch and humeral trochlea were measured in 114 mediolateral elbow extended radiographic views (30 Portuguese Pointing Dog and 27 Estrela Mountain Dog), and 84 mediolateral flexed views (22 Portuguese Pointing Dog and 20 Estrela Mountain Dog). The sampled animals' ages ranged from 12 to 84 months (34.6 ± 17.8 months). Good agreement was observed between curvature radii measurements for flexed vs. extended views in both breed groups. Ulnar trochlear notch curvature radii measurements were greater than humeral trochlea curvature radii measurements in both breed groups. Both curvature radii were greater in the large‐breed dog group vs. the medium‐breed dog group. Both breed groups had ulnar and humeral curves with similar typology. However, the large breed group had greater intermediate differences between the humeroulnar surface curvature radii. Results from this study supported the use of curvature radii as measures of humeroulnar congruity in mediolateral flexed elbow radiographs of medium and large breed dogs. 相似文献
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Trangerud C Grøndalen J Indrebø A Tverdal A Ropstad E Moe L 《Journal of animal science》2007,85(1):76-83
The main objective of this study was to describe the growth patterns of 4 large dog breeds [Newfoundland (NF), Labrador retriever (LR), Leonberger (LEO), and Irish wolfhound (IW)] raised in domestic environments and concomitant changes in 2 growth-related clinical variables: total serum alkaline phosphatase (ALP) and the circumference of the distal radius and ulna (CDRU). The second objective was to investigate whether these measurements were affected by a range of independent variables like age, sex, litter number, and birth weight. Seven hundred dogs were included in the study, and BW data, separated by breed and sex, were fitted to the Gompertz function. Birth weight, adjusted for litter number, differed significantly between sexes for 3 breeds (LEO, P = 0.004; NF, P = 0.02; LR, P = 0.009) and approached significance for IW (P = 0.07). Estimated mean BW increased rapidly during the first 100 d after birth in all 4 breeds, then plateaued, with maturity being reached between 351 (female LR) and 413 d (male NF). Estimated mature BW ranged from 30.8 kg for the female LR up to 65.7 kg for the male IW. Weight gain, as expressed by the derivative of the Gompertz function, reached its peak in the smallest breed (LR) at the youngest age, 89 d for the females and 95 d for males. Log-transformed BW was significantly related to age, breed, and sex, and the age x sex and age x breed interactions. Within breeds, age, birth weight, and litter number had a significant effect on log-transformed BW. The estimated average CDRU increased from 90 d of age toward a peak at 180 d. Thereafter, CDRU declined and stabilized at about 1 yr of age. The estimated total ALP concentrations decreased from 90 to 360 d of age, after which they stabilized, at mean concentrations varying among breeds from 98 to 131 IU/L. Maximum least squares mean total ALP concentrations were found at 3 mo of age in all breeds, with the greatest least squares mean concentration in the IW breed (713 IU/L). In a mixed model analysis of the complete data set, total ALP was affected (P < 0.001) by age, breed, and the interaction of age x breed. This study described the main factors influencing growth and provided reference data for other studies, including those related to nutrition and disorders of growth. 相似文献
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The usefulness of palpation of joint laxity in puppies as a predictor of hip dysplasia in a guide dog breeding programme 总被引:1,自引:0,他引:1
The relationship between puppy hip laxity at 6–8 weeks and radiographic hip dysplasia at 12–18 months was investigated. Two methods of hip laxity assessment were studied and compared. A significant positive relationship was found. Using simple statistical and decision theory principles an approach to the application of these results to a selection programme for guide dogs was discussed and performed. The economic value of early examination for hip dysplasia was demonstrated for the situation studied. 相似文献
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Antje Wigger Bernd Tellhelm Martin Kramer Heike Rudorf 《Veterinary radiology & ultrasound》2008,49(3):243-248
We investigated the prevalence of an anatomic variant of the proximal femur, termed the broomstick-like femoral head and neck formation, and its influence on the Féderation Cynologique Internationale (FCI) hip dysplasia score in 294 German Shepherd dogs. One-hundred and eighty (61%) of the 294 dogs in our study had this anatomic variant. The calculated area of the femoral heads in dogs with a broomstick-like conformation was 4.5 +/- 0.6 cm2 on the hip-extended view. In dogs with a normal femoral head, the calculated area of the femoral head was significantly larger at 4.8 +/- 0.6 cm2 (P < 0.05). In the frog-leg view, there was no significant difference in femoral head area between dogs with the broomstick-like conformation and normal dogs. There was no difference in the antetorsion angle between dogs with broomstick-like conformation and normal dogs. There was also no difference in the distraction ratio between the two phenotypes. The official FCI hip score was similar in dogs with and without the broomstick-like conformation. The average heritability of the broomstick-like conformation was 0.3 +/- 0.1, suggesting heritable influence. We conclude that the broomstick-like conformation is a common finding in the German shepherd dog and has genetic base. The broomstick-like conformation does not appear to be associated with the presence of canine hip dysplasia and it can therefore be assumed to be a normal anatomic variant. 相似文献
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A dorsal tail mass (1 × 1.2 cm) was observed on a 10-year-old castrated male, Shih-tzu dog. A biopsy of the mass was performed and diagnosed histopathologically as a follicular cyst. A necrotic lesion (2.5 × 3 cm) developed at the biopsy site 1 week after sampling and failed to respond to 2 weeks of normal saline cleansing and systemic antibiotic administration. Autologous platelet-rich plasma was applied to the lesion which gradually improved over a 4-week period possibly by a contribution to the secretion of growth hormone, which can accelerate tissue regeneration. This case report suggests that autologous PRP may be beneficial in the management of large skin defects or in delayed wound healing. 相似文献
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Stereotypies are invariant and repetitive behaviour patterns that seemingly have no function, which tend to develop in captive animals faced with insoluble problems and may be indicative of reduced welfare. A 4 year prospective study of the factors influencing the development of stereotypic and redirected behaviours (abnormal behaviour) in a population of 225 young Thoroughbred and part-Thoroughbred horses was conducted between 1995 and 1999. Abnormal behaviour affected 34.7% of the population. Multivariable analysis showed that foals of low- or middle-ranking mares were less likely to develop abnormal behaviour than foals of dominant mares (rate ratio (RR) 0.23, P<0.01; RR 0.48, P<0.01, respectively). Weaning by confinement in a stable or barn was associated with an increased rate of development of abnormal behaviour, compared with paddock-weaning (RR 2.19, P<0.05), and housing in barns, rather than at grass after weaning, was associated with a further increase (RR 2.54, P<0.01). Specific stereotypic and redirected behaviours were then considered as separate outcomes. Crib-biting was initiated by 10.5% of horses at median age 20 weeks, weaving by 4.6% of horses at median age 60 weeks, box-walking by 2.3% of horses at median age 64 weeks and wood-chewing by 30.3% of horses at median age 30 weeks. Wood-chewing developed at a lower rate in horses born to subordinate or mid-ranking mares than in horses born to dominant mares (RR 0.29, P<0.01; RR 0.41, P<0.01, respectively), and at a higher rate in horses kept in barns or stables rather than at grass after weaning (RR 4.49, P<0.001; RR 1A6, P<0.001, respectively). Feeding concentrates after weaning was associated with a 4-fold increase in the rate of development of crib-biting (RR 4.12, P = 0.02). The results of this study support the idea that simple changes in feeding, housing and weaning practices could substantially lower the incidence of abnormal behaviour in young horses. 相似文献
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Valérie Chetboul Cécile Damoiseaux Camille Poissonnier Marie Lavennes Sandrine Bertrand Nicolas Borenstein Luc Behr Jean-Louis Pouchelon Vassiliki Gouni Loïc Desquilbet 《Journal of Veterinary Cardiology》2018,20(6):405-414
Introduction
The objectives of this study were to characterize the epidemiological, clinical, and echocardiographic features of French bulldogs (FBs) with congenital pulmonic stenosis and document their survival times and risk factors for cardiac death (CD).Animals
This study included 66 FBs with congenital pulmonic stenosis.Methods
Prospective cohort study including a survival analysis to assess time to CD.Results
In most cases (53/66, 80%), at least two obstructive lesions were observed, most commonly valvular and supravalvular (42/66, 64%), with pulmonary trunk hypoplasia in 40/66 (61%) of cases. The median Doppler-derived peak trans-stenotic pressure gradient (ΔP) was very high: 170 mmHg (range = 34–291 mmHg), with ΔP ≥ 200 mmHg in 33% of FBs. Among the 51 FBs with an available follow-up and that did not undergo surgical valvuloplasty, 21/51 (41%) died, 67% (14/21) of deaths being CD. The median survival time from diagnosis to CD was 2.8 years (interquartile range = 0.8–4.6 years). Univariate Cox proportional hazard analyses revealed that age (hazard ratio [HR] = 2.3 per 1 year increase; p = 0.02), clinical signs at presentation (HR = 3.7; p = 0.03), ΔP (HR = 1.2 per 10 mmHg increase; p = 0.01), right ventricular dilation (HR = 5.0; p = 0.04), severe tricuspid regurgitation (HR = 7.6; p = 0.001), and right-sided congestive heart failure (HR = 4.8; p = 0.05) were associated with time to CD. After adjustment for age and ΔP, tricuspid regurgitation remained significantly associated with time to CD (HR = 5.1; p = 0.02).Conclusions
Pulmonic stenosis in FBs is commonly severe and complex, with at least 2 obstructive lesions in most cases, a high incidence of pulmonary trunk hypoplasia and CD, and strong association between prognosis and tricuspid regurgitation severity. 相似文献16.
Semen (collected by digital manipulation) and peripheral blood samples were obtained twice weekly from five fully grown Beagle dogs for a twelve month period from 1st August to 31st July. Sperm concentration, sperm output and glycerylphosphorylcholine concentrations of the second fraction showed evidence of a seasonal variation with highest values recorded in the months of March, April, May and June. The libido of the dogs, volume of ejaculate, percentage dead and abnormal spermatozoa, sperm motility and plasma testosterone concentration showed no evidence of seasonal change. 相似文献
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Epizootic of external and internal abscesses in a large goat herd over a 16-year period 总被引:1,自引:0,他引:1
H M Gezon H D Bither L A Hanson J K Thompson 《Journal of the American Veterinary Medical Association》1991,198(2):257-263
From 1973 through 1988, 518 external and internal abscesses were diagnosed in a large commercial goat herd. Of the 518 abscesses, 238 were primary and 280 were secondary abscesses in the same or other anatomic locations. During this period, the herd varied in size from 94 goats in 1973 to 431 goats in 1988. Abscesses in the jaw area were detected in 141 goats, 4 of which developed osteomyelitis of the mandible. Sternal abscesses were detected in 72 goats, with 2 also having osteomyelitis of the sternum diagnosed at necropsy. Most of the abscesses were in the jaw, sternal, facial, and cervical areas. Lung abscesses were diagnosed at necropsy in 20 goats that most recently had 1 or more superficial abscesses. Abscess incidence was 27.6% (112 of 406) in wethers and 22.9% (154 of 687) in does. Actinomyces pyogenes was isolated most frequently by bacteriologic culture of abscess specimens and about 3 times as often as was Corynebacterium pseudotuberculosis or Staphylococcus sp, usually coagulase-positive S aureus. Bacteriologic culture of blood samples, taken during abscess episodes, yielded A pyogenes (n = 3) or C pseudotuberculosis (n = 1) in 3 goats. Results of antibiotic treatment of abscesses were disappointing, with little evidence of altering the course of the disease or sterilizing the abscess, despite the fact that the bacteria were susceptible in vitro to the antibiotics used. Excision of intact abscesses was the preferred treatment for abscesses of the jaw and facial areas.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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264 ejaculate samples taken from seven boars were tested for the bacteriostatic action of apramycin and for its effect on some sperm quality parameters during 96-hour storage. Apralan soluble powder, produced by Elanco Products Limited, was used in the trials at the concentrations of 2.5 to 500 mg per 1000 ml of diluent. The preparation was evaluated according to sperm motility during storage, according to the concentration pattern of hydrogen ions, morphological changes in spermatozoa, thermoresistance test, bacteriological tests and other examinations. The concentrations of 200 to 250 mg of apramycin in combination with 500 000 i. u. of G-penicillin potassium salt had a statistically significantly more favourable effect on the survival of boar sperm, as compared with the combination of streptomycin with penicillin. 相似文献
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I Alitalo E Heikkinen S Paatsama L Punto J Puranen P Virkkunen 《Acta veterinaria Scandinavica》1983,24(3):247-251
Three clinical cases of canine avascular femoral head necrosis and 4 cases of hip dysplasia were examined using intraosseus femoral neck venography. The contrast medium passed initio the diaphyseal bone marrow in all cases. Three growing dogs and 7 growing pigs were examined with the same method, before and after experimental ligation of the femoral veins. Before the venous tamponade, no contrast medium was visible in the femoral neck. The venography performed immediately after ligation showed contrast flow into the femoral neck similar to that seen in the clinical cases of Legg Perthes disease or hip dysplasia. However, a collateral circulation developed within 7 weeks. No more contrast-flow into the diaphysis was observed after that time.Although osteomedullography shows that both in Perthes disease and in hip dysplasia venous drainage has failed, venous tamponade may not induce the onset of the disease.Key words: hip dysplasia, Legg Perthes disease, osteomedullography 相似文献
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The effect of repeated eye examinations and breeding advice on the prevalence and incidence of cataracts and progressive retinal atrophy in German dachshunds over a 13‐year period
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Sarah Koll Sven Reese Ivica Medugorac Carsten U. Rosenhagen Rick F. Sanchez Roberto Köstlin 《Veterinary ophthalmology》2017,20(2):114-122