TREATMENT OF UNILATERAL PERINEAL HERNIAS IN 2 MALE CHINCHILLAS (CHINCHILLA LANIGERA)

Two sexually intact adult male chinchillas were presented with a swelling in the perineal region. Radiographically both masses had a soft tissue opacity. Ultrasonography confirmed the tentative diagnosis of perineal hernia. In the first case the ultrasonographic examination revealed a fluid-filled structure inside the swelling, which was determined to be the urinary bladder. In the second case the hernia sac was filled with homogeneous tissue, belived to be fat. Subsequently, unilateral perineal herniorrhaphies including an internal obturator muscle flap transposition technique were performed. Both chinchillas recovered well with subsequent uneventful healing of the surgical sites. No long-term complications or recurrences of the perineal hernias were reported. This clinical report shows that perineal hernias occur in chinchillas and can be surgically treated with success.     

UTERINE LEIOMYOMA,FIBROMA, AND HEMANGIOMA IN 2 CHINCHILLAS (CHINCHILLA LANIGER)

Two female chinchillas were presented with reduced appetite and production of small fecal pellets. Physical examination of both chinchillas revealed a reduced vaginal membrane, bloody vaginal discharge, and a palpable mass in the caudal abdomen. Radiographic images revealed soft tissue masses in the caudal abdomen of both animals. In addition, the first case was examined by ultrasound, which identified 2 cystic masses, each originating from 1 of the uteri. Both chinchillas were euthanized due to progressive clinical deterioration with both animals undergoing postmortem examinations. Grossly the uterine masses were confirmed, in the first case adhering to the jejunum and mesojejunum and in the second case leading to compression of the rectum in the pelvic cavity. Histopathological examination and immunohistochemical staining of the masses were consistent with presence of uterine leiomyoma and fibroma in the first case and a uterine hemangioma in the second case. The bloody vaginal discharge was assumed to be caused by the fibroma with multifocal acute hemorrhages and rupture of the hemangioma, respectively. The presented cases intend to increase the knowledge base of chinchilla oncology.     

腐霉素的安全性及药效研究

本文报道了腐霉素钠盐的安全性及药效的研究成果,包括大、小鼠及雏鸡急性毒性试验、蓄积毒性及耐受性试验、肉鸡喂养试验和药效试验。本研究的初步结果表明,腐霉素钠盐做为一种新的聚醚类抗球虫药物添加剂安全有效,最适宜的混料浓度为160ppm。     

腐霉素的安全性及药效研究 Ⅱ.腐霉素的致畸作用

本文研究了腐霉素钠盐对Wistar大鼠的致畸作用。传统致畸试验,以1/5、1/15、1/45及1/135LD_(50)4个剂量的腐霉素进行试验,结果表明,1/5 LD_(50)组孕鼠已出现体重下降和死亡、吸收胎率和死胎率升高(P<0.05)诸现象,但各剂量组未产生明显的致畸作用(P>0.05)。喂养致畸试验,以1/10、1/50及1/100 LD_(50)3个剂量的腐霉素连续混料饲喂大鼠90天,然后交配检查,结果表明各剂量组均未出现任何明显的致畸作用(P>0.05)。腐霉素致畸指数小于10,属非致畸物。     

多拉菌素对猪寄生虫病的驱虫效果观察

比较不同来源的多拉菌素对猪消化道线虫和体表寄生虫的驱杀效果,为临床应用该药提供科学依据。将自然感染寄生虫的猪,随机分为高、中、低3个剂量的药物试验组和不给药物治疗对照组,健康无寄生虫感染的猪作为对照,根据试验前和试验后7、14、28、35 d猪寄生虫数量和临床变化判定疗效。结果显示,海正多拉与辉瑞通灭对猪的体表寄生虫及消化道线虫均有极好的驱杀作用,临床推荐剂量以中剂量组300μg/kg·BW肌肉注射为宜。     

猴卡氏肺孢子虫肺炎模型的建立及蒿甲醚的疗效试验

从住家附近诱捕到 13只野鼠 ,经皮下注射醋酸可的松 10周 ,建立野鼠卡氏肺孢子虫肺炎模型 ,取野鼠肺组织制成接种物。 1～ 6号实验猴经气管接种 3 6× 10 6 卡氏肺孢子虫包囊 ,接种前 5d至接种后 35d注射醋酸可的松。 7～ 12号实验猴经气管接种 7 2× 10 6 卡氏肺孢子虫包囊。接种后 ,1～ 6号实验猴出现严重的临床症状 ,病理变化呈典型的卡氏肺孢子虫肺炎 ;7～ 12号实验猴为亚临床症状 ,经注射醋酸可的松后 ,则出现类似于 1～ 6号实验猴的严重症状和病理变化。实验结果表明实验猴免疫力低下时 ,接种外源性卡氏肺孢子虫包囊可导致典型的卡氏肺孢子虫肺炎 ;呈隐性感染的实验猴经免疫抑制处理后 ,亦可导致卡氏肺孢子虫肺炎。用蒿甲醚对呈卡氏肺孢子虫肺炎的实验猴进行治疗 ,取得明显的治疗效果     

EFFECT AND SAFETY OF MEGLUMINE IOTROXATE FOR CHOLANGIOCYSTOGRAPHY IN NORMAL CATS

The biliary opacification characteristics and toxicity of meglumine iotroxate (Biliscopin) were studied in twenty-three normal cats. Intravenous administraion of 72 mg/kg of Biliscorpin resulted in opacification of the gallbladder and bile duct 20 minutes after administration. Licking and vomiting appeared in ten of twelve cats immediately after administration. These side-effects were abolished by administration of an anti-histaminic agent. Slight elevation in ALT or AST was detected 24 hours after administration of Biliscopin. These findings suggest that Biliscopin can be used safely in the cat.     

优素精~和盐霉素之笼饲药效试验

优素精￣（日本科研制药株式会社制品）和盐霉素（山东济宁抗生素厂制品）之抗球虫效力的比较试验。１４日龄艾维因肉鸡分４组；Ⅰ、盐霉素组；Ⅱ、优素精组；Ⅲ、感染不给药对照组；Ⅳ、不感染不给药对照组。每组６笼，每笼１０只（公母各５只）。优素精和盐霉素均以６０ｐｐｍ之浓度混合于饲料中，自由摄食。１６日龄时，Ⅰ、Ⅱ、Ⅲ组分别经口感染Ｅ．ａｃｅｒｖｕｌｉｎａ，Ｅ．ｍａｘｉｍａ和Ｅ．ｔｅｎｅｌｌａ混合卵囊，每鸡１０．１２×１０￣４。２３日龄（感染后７天）解剖全部鸡。依增重，饲料利用效率，血粪，卵囊排出量，球虫病变值和球虫病死亡率判断抗球虫效力。试验结果：优素精组的平均增重（２７０．０８克）和饲料利用率（２．０３）是试验各组中最优良的。比不感染不给药对照组优越，生物统计差异显著（Ｐ＜０．０１）。盐霉素组的平均增重（２６２．４２克）和饲料利用率（２．０８）虽高于不感染不给药对照组，但其差异不显著（Ｐ＞０．０５）。优素精组的球虫病变值比感染不给药对照组低４６．４０％，比盐霉素组低３６．２９％，卵囊排出量比感染不给药对照组低９７．２５％，比盐霉素组低２０．０４％。本试验证明，优素精有强烈的抗球虫药效，同时也证明有促进生长，加速增重?     

SCINTIGRAPHIC DETECTION OF SUBCUTANEOUS METASTASIS IN A DOG WITH APPENDICULAR OSTEOSARCOMA

This report describes the detection of subclinical soft tissue metastasis of an appendicular osteosarcoma in a dog using bone scintigraphy. A 7-year-old spayed female Rottweiler was presented with a biopsy confirmed diagnosis of osteosarcoma. Initial radiographs revealed an aggressive bone lesion of the left distal radius. At presentation, there was no clinical or radiographic evidence of metastasis; however, a nuclear bone scan showed the primary bone lesion of the distal left radius and numerous soft tissue lesions consistent with diffuse soft tissue metastases. A left foreleg amputation was performed and cisplatin chemotherapy was given post-operatively. A second bone scan performed one month following initial presentation showed progression in size and number of soft tissue masses. Many of the lesions had become apparent on physical exam and survey radiographs. Excisional biopsy was performed on one of the soft tissue masses and a diagnosis of metastatic osteosarcoma was made. The dog was euthanized 2 months after initial presentation at the owners request due to deterioration of the animals physical condition.     

CONTRAST-ENHANCED ULTRASONOGRAPHY IN NORMAL CANINE LIVER. EVALUATION OF IMAGING AND SAFETY PARAMETERS

Contrast-enhanced ultrasonography, a new imaging modality in veterinary medicine, can provide data on tissue perfusion. The objective of this study was to use the ultrasonographic contrast agent SonoVue to evaluate various transit time indices in the normal canine liver, to examine the effect of anesthesia on these parameters, and to evaluate the safety of this agent in dogs. The liver of 11 healthy dogs was studied by ultrasound during an intravenous bolus injection of SonoVue. Each dog underwent the examination twice, first with and later without the use of anesthesia. A time-intensity curve was generated from a selected region of interest within the liver from each scanning session. Ratios derived from peak enhancement, time to peak enhancement, up-slope and full-width half-maximum (FWHM) of the curve were calculated from the time-intensity curves, and are reported. There were no statistically significant differences (P > 0.05) in peak enhancement, up-slope and FWHM between dogs that were anesthetized and dogs that were not. Time to peak enhancement, however, was significantly shorter when the dogs were anesthetized than when they were nonanesthetized (P < 0.05). There were no biologically significant changes in clinical laboratory findings. This study indicates that contrast-enhanced ultrasound using SonoVue gives reproducible liver perfusion data, and appears to be a safe and well-tolerated agent for use in dogs. When considering normal values, the use of anesthetic drugs has to be considered.     

应用盐酸克伦特罗作饲料添加剂饲喂家畜对消费者的安全问题

应用盐酸克伦特罗(HCl-Clenbuterol)作饲料添加剂饲喂家畜 ,借以提高其瘦肉率和减少其脂肪率已在欧洲导致多次的消费者集体中毒事件 ,促使欧美政府明令畜牧业禁用此药。中国农业部及药品检查管理局于2000年明令禁止生产、销售和应用此药作饲料添加剂饲喂家畜。本文综述了有关此药导致消费者集体中毒的事件和检验该药在肉品中残留量的精确方法及选择供检验该药残留量的合宜的畜体器官与组织标样等情况 ,借以提高国人认识应用此药作饲料添加剂对人的危害性 ,从而全力支持、拥护、贯彻执行我国政府的禁令 ,达到保证人民健康的目的     

THE INFLUENCE OF THE TIME OF TREATMENT IN RELATION TO FEEDING ON THE EFFICACY OF AMOXYCILLIN THERAPY IN DOGS AND CATS

SUMMARY A field trial comparing the clinically assessed response to amoxycillin therapy in 148 fasted and 129 non-fasted dogs and cats suffering clinically diagnosed bacterial infections is reported. A satisfactory response to treatment was obtained in 88.8% of these cases. The results indicate that the clinical response to amoxycillin therapy was not affected by the concurrent administration of the antibiotic with food.