共查询到20条相似文献,搜索用时 15 毫秒
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Malaria research--what next? 总被引:1,自引:0,他引:1
E Marshall 《Science (New York, N.Y.)》1990,247(4941):399-402
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J Cherfas 《Science (New York, N.Y.)》1990,247(4941):402-403
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Malaria is a devastating public health menace, killing over one million people every year and infecting about half a billion. Here it is shown that the protozoan Plasmodium gallinaceum, a close relative of the human malaria parasite Plasmodium falciparum, can develop in the fruit fly Drosophila melanogaster. Plasmodium gallinaceum ookinetes injected into the fly developed into sporozoites infectious to the vertebrate host with similar kinetics as seen in the mosquito host Aedes aegypti. In the fly, a component of the insect's innate immune system, the macrophage, can destroy Plasmodia. These experiments suggest that Drosophila can be used as a surrogate mosquito for defining the genetic pathways involved in both vector competence and part of the parasite sexual cycle. 相似文献
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Malaria parasites adopt host cell superoxide dismutase 总被引:10,自引:0,他引:10
Aerobic organisms depend on superoxide dismutase to suppress the formation of dangerous species of activated oxygen. Intraerythrocytic stages of the malaria parasite exist within a highly aerobic environment and cause the generation of increased amounts of activated oxygen. Plasmodium berghei in mice was found to derive a substantial amount of superoxide dismutase activity from the host cell cytoplasm. Plasmodia isolated from mouse red cells contained mouse superoxide dismutase, whereas rat-derived parasites contained the rat enzyme. This is believed to be the first example of the acquisition of a host cell enzyme by an intracellular parasite. 相似文献
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Alphey L Beard CB Billingsley P Coetzee M Crisanti A Curtis C Eggleston P Godfray C Hemingway J Jacobs-Lorena M James AA Kafatos FC Mukwaya LG Paton M Powell JR Schneider W Scott TW Sina B Sinden R Sinkins S Spielman A Touré Y Collins FH 《Science (New York, N.Y.)》2002,298(5591):119-121
At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in the control of vector-borne diseases. 相似文献
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Maugh TH 《Science (New York, N.Y.)》1977,196(4288):413-416
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Marshall E 《Science (New York, N.Y.)》1983,220(4596):485
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Enserink M 《Science (New York, N.Y.)》2000,287(5460):1956-1958
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Pennisi E 《Science (New York, N.Y.)》2002,298(5591):33-34
This week, an almost complete DNA sequence of Plasmodium falciparum--one of the parasites that causes malaria--appears in Nature, and on page 129 of this issue of Science, other researchers report the DNA sequence of Anopheles gambiae, one of the mosquitoes that transmits P. falciparum to humans. Together with the human genome sequence, researchers now have in hand the genetic blueprints for the parasite, its vector, and its victim. 相似文献
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Vogel G 《Science (New York, N.Y.)》2004,306(5696):587-589
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