家畜Toll样受体的表达及在相关疾病发生中的作用

家畜的Toll样受体(TLRs)是家畜天然免疫相关分子家族中的重要组成部分。不同家畜表达的TLRs分子也各不相同,而同一种家畜的不同组织中表达的TLRs分子也不一定相同。这些TLRs分子在家畜疫病的发生、发展及治疗中也具有重要作用。目前虽然对于人和小鼠TLRs分子的研究已经较为全面,但是对于家畜TLRs的研究并不十分深入。论文主要就不同家畜TLRs分子研究的概况、不同家畜的TLRs在组织中的分布,以及TLRs在相关家畜疫病中的重要作用进行简要概述,以期对家畜TLRs分子信号转导通路的研究及家畜疫病的防控、新型疫苗和佐剂的开发提供参考。     

畜禽基因定位的现状和展望

本文对畜禽基因定位的内容、方法和现状进行了综述。提出了基因定位中存在的主要问题是定位精度不高，方法有待进一步完善。我国开展此项工作应将重点放大中国畜禽特有性状和重要经济性状上。     

Stem Cells from Foetal Adnexa and Fluid in Domestic Animals: An Update on Their Features and Clinical Application

Over the past decade, stem cell research has emerged as an area of major interest for its potential in regenerative medicine applications. This is in constant need of new cell sources to conceive regenerative medicine approaches for diseases that are still without therapy. Scientists drew the attention towards alternative sources such as foetal adnexa and fluid, as these sources possess many advantages: first of all, cells can be extracted from discarded foetal material and it is non‐invasive and inexpensive for the patient; secondly, abundant stem cells can be obtained; and finally, these stem cell sources are free from ethical considerations. Cells derived from foetal adnexa and fluid preserve some of the characteristics of the primitive embryonic layers from which they originate. Many studies have demonstrated the differentiation potential in vitro and in vivo towards mesenchymal and non‐mesenchymal cell types; in addition, the immune‐modulatory properties make these cells a good candidate for allo‐ and xenotransplantation. Naturally occurring diseases in domestic animals can be more ideal as disease model of human genetic and acquired diseases and could help to define the potential therapeutic use efficiency and safety of stem cells therapies. This review offers an update on the state of the art of characterization of domestic animals' MSCs derived from foetal adnexa and fluid and on the latest findings in pre‐clinical or clinical setting of the stem cell populations isolated from these sources.     

家养动物FSHR基因的结构功能与表达调控研究进展

促卵泡激素FSH及其受体在卵巢的卵泡发育和激素生成以及睾丸的精子生成中起关键的调节作用。促卵泡激素受体FSHR与家养动物的繁殖能力有密切关系。提高家畜产仔率是确保我国动物养殖业持续健康发展的主要方向。已有研究表明,FSHR基因对动物的卵巢卵泡生长发育和精子发生具有巨大的调控作用,并且该基因与家养动物的繁殖性状,繁殖能力存在一定的关联性。本文章旨在介绍FSHR的结构,表达和生物学功能,以及在家养动物(牛,绵羊,山羊,猪和鸡)方面的研究展开综述,并且对其存在的问题及发展方向提出展望。     

精原干细胞移植在家畜生产中的应用

本文阐述了精原干细胞的分离纯化、冷冻保存、移植等一系列相关研究技术 ,同时围绕国内外最新研究进展展望了精原干细胞在家畜生产上的潜在应用     

放牧家畜牧食行为研究进展

放牧家畜牧食行为在草地生态学、自然资源保护与利用以及畜牧业生产中具有重要意义.对放牧家畜在不同放牧强度、不同放牧时期和不同放牧制度下的牧食行为的研究进行综述,系统地分析和讨论了放牧家畜的牧食行为.