共查询到20条相似文献,搜索用时 9 毫秒
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The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape. 相似文献
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Kato H Goto DB Martienssen RA Urano T Furukawa K Murakami Y 《Science (New York, N.Y.)》2005,309(5733):467-469
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Specific inhibition of nuclear RNA polymerase II by alpha-amanitin 总被引:75,自引:0,他引:75
T J Lindell F Weinberg P W Morris R G Roeder W J Rutter 《Science (New York, N.Y.)》1970,170(956):447-449
alpha-Amanitin, a toxic substance from the mushroom Amanita phalloides, is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a complex of DNA and polymerase II. 相似文献
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Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation. 相似文献