共查询到20条相似文献,搜索用时 0 毫秒
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J L Marx 《Science (New York, N.Y.)》1980,208(4448):1127-1130
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G Kolata 《Science (New York, N.Y.)》1983,220(4602):1137-1138
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Gura T 《Science (New York, N.Y.)》1999,283(5406):1238-1239
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J Marx 《Science (New York, N.Y.)》1990,248(4962):1491-1493
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Bachmaier K Neu N de la Maza LM Pal S Hessel A Penninger JM 《Science (New York, N.Y.)》1999,283(5406):1335-1339
Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle-specific alpha myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae, C. psittaci, and C. trachomatis was shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle-specific peptide. Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle-specific epitopes. Thus, Chlamydia-mediated heart disease is induced by antigenic mimicry of a heart muscle-specific protein. 相似文献
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目的 了解妊娠早期胎儿心脏轴检查对先天性心脏病的检出意义.方法159例早期妊娠(11~14周)孕妇行胎儿心脏超声检查,比较心脏病组(n=47)和对照组(n=112)胎儿心脏轴、颈项透明层增厚、三尖瓣返流和静脉导管血液倒流等指标的差异.结果 心脏病组孕妇的胎儿心脏轴正常者明显少于对照组(P<0.01),而左偏、右偏和不能测量者均比对照组高(P<0.05或0.01).对圆锥动脉干畸形、单心室类心脏病和两种以上心脏病的胎儿,心脏轴异常发生率比颈项透明层增厚、三尖瓣返流和静脉导管血液倒流等发生率均高(P<0.05或0.01).结论 妊娠早期胎儿心脏轴测量有利于检出先天性心脏病. 相似文献
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J L Marx 《Science (New York, N.Y.)》1989,243(4889):315-316
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Maugh TH 《Science (New York, N.Y.)》1973,181(4099):534-535
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Kolata GB 《Science (New York, N.Y.)》1976,194(4269):1029-1031
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P J 《Science (New York, N.Y.)》1990,247(4947):1171
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Marx J 《Science (New York, N.Y.)》2003,300(5625):1492-1496
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Irisin是新近在骨骼肌中发现的肌肉因子,可促进白色脂肪细胞''棕色化'',增加能量消耗、降低体重。运动通过影响Irisin、UCP1的表达来调控脂代谢进而改善肥胖、糖尿病等代谢性疾病,但不同运动方式和运动强度对Irisin表达的影响规律并不相同。将深入探讨运动调控Irisin表达变化的作用机制,旨为防治肥胖等代谢性疾病提供新视角。 相似文献
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