Preventing AIDS but not HIV-1 infection with a DNA vaccine

Although there has been some success in treating human immunodeficiency virus (HIV) patients with triple drug therapy (highly active antiretroviral therapy or HAART), the best hope for combating AIDS (the disease caused by HIV) could be a combination of drug therapy and vaccination, according to Shen and Siliciano in their Perspective. A new study in rhesus monkeys treated with a DNA vaccine (Barouch et al.) demonstrates that a powerful vaccine-induced CD8(+) cytolytic T cell response reduces the amount of virus in the blood to very low levels preventing the drastic decrease in CD4(+) T helper cells and subsequent immunodeficiency. As the Perspective authors explain, vaccinating HIV patients that are receiving HAART may enable HIV levels to be permanently brought under control such that the drug treatment can eventually be stopped.     

IBV肾型毒株与呼吸型疫苗株鉴别方法的建立与应用

[目的]建立基于鸡传染性支气管炎病毒(IBV)S1基因的反转录-复合PCR方法,为IBV流行毒株和呼吸型疫苗株的分型鉴定提供技术支持.[方法]根据IBV N基因序列设计合成1对特异性通用引物,建立IBV的分子生物学检测方法,用以对IBV进行检测.通过对GenBank上公布的IBV S1基因全序列的分析比对,找出呼吸型疫...