Social comparison affects reward-related brain activity in the human ventral striatum

Whether social comparison affects individual well-being is of central importance for understanding behavior in any social environment. Traditional economic theories focus on the role of absolute rewards, whereas behavioral evidence suggests that social comparisons influence well-being and decisions. We investigated the impact of social comparisons on reward-related brain activity using functional magnetic resonance imaging (fMRI). While being scanned in two adjacent MRI scanners, pairs of subjects had to simultaneously perform a simple estimation task that entailed monetary rewards for correct answers. We show that a variation in the comparison subject's payment affects blood oxygenation level-dependent responses in the ventral striatum. Our results provide neurophysiological evidence for the importance of social comparison on reward processing in the human brain.     

Separate neural systems value immediate and delayed monetary rewards

When humans are offered the choice between rewards available at different points in time, the relative values of the options are discounted according to their expected delays until delivery. Using functional magnetic resonance imaging, we examined the neural correlates of time discounting while subjects made a series of choices between monetary reward options that varied by delay to delivery. We demonstrate that two separate systems are involved in such decisions. Parts of the limbic system associated with the midbrain dopamine system, including paralimbic cortex, are preferentially activated by decisions involving immediately available rewards. In contrast, regions of the lateral prefrontal cortex and posterior parietal cortex are engaged uniformly by intertemporal choices irrespective of delay. Furthermore, the relative engagement of the two systems is directly associated with subjects' choices, with greater relative fronto-parietal activity when subjects choose longer term options.     

Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium

Addiction profoundly alters motivational circuits so that drugs become powerful reinforcers of behavior. The interoceptive system continuously updates homeostatic and emotional information that are important elements in motivational decisions. We tested the idea that interoceptive information is essential in drug craving and in the behavioral signs of malaise. We inactivated the primary interoceptive cortex in amphetamine-experienced rats, which prevented the urge to seek amphetamine in a place preference task. Interoceptive insula inactivation also blunted the signs of malaise induced by acute lithium administration. Drug-seeking and malaise both induced Fos expression, a marker of neuronal activation, in the insula. We conclude that the insular cortex is a key structure in the perception of bodily needs that provides direction to motivated behaviors.     

运动员体育道德TARGET模式的干预研究*

探讨在运动训练中实施TARGET模式的干预对大学生运动员体育道德取向的影响。选取50名大学生篮球运动员为被试,采用心理测量的方法分别对实验组和对照组被试进行前后测。结果显示,实验干预后,学生掌握气氛、任务取向水平显著升高,而成绩气氛和自我取向没有显著变化,学生体育道德各维度指标显著改善。结论：TARGET模式的干预策略有利于营造掌握气氛,促进学生的任务取向,从而形成积极的体育道德取向。     

The neural basis of altruistic punishment

Many people voluntarily incur costs to punish violations of social norms. Evolutionary models and empirical evidence indicate that such altruistic punishment has been a decisive force in the evolution of human cooperation. We used H2 15O positron emission tomography to examine the neural basis for altruistic punishment of defectors in an economic exchange. Subjects could punish defection either symbolically or effectively. Symbolic punishment did not reduce the defector's economic payoff, whereas effective punishment did reduce the payoff. We scanned the subjects' brains while they learned about the defector's abuse of trust and determined the punishment. Effective punishment, as compared with symbolic punishment, activated the dorsal striatum, which has been implicated in the processing of rewards that accrue as a result of goal-directed actions. Moreover, subjects with stronger activations in the dorsal striatum were willing to incur greater costs in order to punish. Our findings support the hypothesis that people derive satisfaction from punishing norm violations and that the activation in the dorsal striatum reflects the anticipated satisfaction from punishing defectors.     

The influence of a sense of time on human development

The subjective sense of future time plays an essential role in human motivation. Gradually, time left becomes a better predictor than chronological age for a range of cognitive, emotional, and motivational variables. Socioemotional selectivity theory maintains that constraints on time horizons shift motivational priorities in such a way that the regulation of emotional states becomes more important than other types of goals. This motivational shift occurs with age but also appears in other contexts (for example, geographical relocations, illnesses, and war) that limit subjective future time.     

Adaptive coding of reward value by dopamine neurons

It is important for animals to estimate the value of rewards as accurately as possible. Because the number of potential reward values is very large, it is necessary that the brain's limited resources be allocated so as to discriminate better among more likely reward outcomes at the expense of less likely outcomes. We found that midbrain dopamine neurons rapidly adapted to the information provided by reward-predicting stimuli. Responses shifted relative to the expected reward value, and the gain adjusted to the variance of reward value. In this way, dopamine neurons maintained their reward sensitivity over a large range of reward values.     

Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons

Using sensory information for the prediction of future events is essential for survival. Midbrain dopamine neurons are activated by environmental cues that predict rewards, but the cellular mechanisms that underlie this phenomenon remain elusive. We used in vivo voltammetry and in vitro patch-clamp electrophysiology to show that both dopamine release to reward predictive cues and enhanced synaptic strength onto dopamine neurons develop over the course of cue-reward learning. Increased synaptic strength was not observed after stable behavioral responding. Thus, enhanced synaptic strength onto dopamine neurons may act to facilitate the transformation of neutral environmental stimuli to salient reward-predictive cues.     

Reward timing in the primary visual cortex

We discovered that when adult rats experience an association between visual stimuli and subsequent rewards, the responses of a substantial fraction of neurons in the primary visual cortex evolve from those that relate solely to the physical attributes of the stimuli to those that accurately predict the timing of reward. In addition to revealing a remarkable type of response plasticity in adult V1, these data demonstrate that reward-timing activity-a "higher" brain function-can occur very early in sensory-processing paths. These findings challenge the traditional interpretation of activity in the primary visual cortex.     

Lacking control increases illusory pattern perception

We present six experiments that tested whether lacking control increases illusory pattern perception, which we define as the identification of a coherent and meaningful interrelationship among a set of random or unrelated stimuli. Participants who lacked control were more likely to perceive a variety of illusory patterns, including seeing images in noise, forming illusory correlations in stock market information, perceiving conspiracies, and developing superstitions. Additionally, we demonstrated that increased pattern perception has a motivational basis by measuring the need for structure directly and showing that the causal link between lack of control and illusory pattern perception is reduced by affirming the self. Although these many disparate forms of pattern perception are typically discussed as separate phenomena, the current results suggest that there is a common motive underlying them.     

Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention

More than one-third of all people are estimated to experience mild to severe cognitive impairment as they age. Acetylcholine (ACh) levels in the brain diminish with aging, and nicotinic ACh receptor (nAChR) stimulation is known to enhance cognitive performance. The prefrontal cortex (PFC) is involved in a range of cognitive functions and is thought to mediate attentional focus. We found that mice carrying nAChR β2-subunit deletions have impaired attention performance. Efficient lentiviral vector-mediated reexpression of functional β2-subunit-containing nAChRs in PFC neurons of the prelimbic area (PrL) completely restored the attentional deficit but did not affect impulsive and motivational behavior. Our findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance.     

四川省农业自主创新动力机制研究

对农业自主创新动力机制的内涵、构成要素进行了理论分析,在此基础上对四川省农业自主创新动力机制的现状和存在的问题进行了探讨,并从激励机制、约束机制、产权机制等方面提出了进一步完善四川省农业自主创新动力机制的对策建议。     

关于生产队建立生产责任制后奖赔核算问题的探讨

党的十一届三中全会以来,广大农村社队普遍建立了各种形式的生产责任制,对会计核算提出了新的课题。各种形式的生产责任制内容不同,有的有奖赔,有的无奖赔。本文仅就实行责任制后的奖赔核算问题提出一些看法,以供商讨。     

BOLD responses reflecting dopaminergic signals in the human ventral tegmental area

Current theories hypothesize that dopamine neuronal firing encodes reward prediction errors. Although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fMRI) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (VStr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (VTA) and substantia nigra]. We used fMRI tailored to directly image the brainstem. When primary rewards were used in an experiment, the VTA blood oxygen level-dependent (BOLD) response reflected a positive reward prediction error, whereas the VStr encoded positive and negative reward prediction errors. When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events.     

自助式整体薪酬在农信系统职业经理人激励中的应用

从现行农信系统职业经理人激励中存在的问题入手,结合职业经理人自身的特点,对自助式整体薪酬在职业经理人激励中的特点和优点进行了研究,在此基础上,对自助式整体薪酬的具体实施和应注意的问题进行了简要分析。     

模糊综合评判在高校图书馆员业绩考核中的应用

对高校图书馆员进行业绩考核,并使待遇、奖惩与考核结果挂钩,这是高校图书馆调动馆员积极性的一项常见的且极其重要的措施。然而目前许多高校图书馆员业绩的考核方法存在很多不足。文章采用多因素层次模糊综合评判法对图书馆员业绩进行评判,可同时得出定量结果和定性结论,据此,图书馆员可扬长避短,图书馆管理层可调整馆员岗位、采取相应的奖惩措施,以提高馆员素质、发挥图书馆的优势,增强高校的核心竞争力。     

Community shared agriculture

Community shared agriculture is a concept that brings food producers and consumers together in a relationship that supports values associated with sustainable agriculture, community development, and food security. At the heart of the concept is the notion of sharing. Participants share the real costs of food production through fair prices for the farmer and by assuming part of the risk of poor harvests. They also share the rewards that come through a seasons supply of fresh produce, the development of fellowship, and the knowledge that they are part of an effort to “think globally, act locally.”     

Eye-tracking patterns in schizophrenia

A significant number of schizophrenic patients show patterns of smooth pursuit eye-tracking patterns that differ strikingly from the generally smooth eye-tracking seen in normals and in nonschizophrenic patients. These deviations are probably referable not only to motivational or attentional factors, but also to oculomotor involvement that may have a critical relevance for perceptual dysfunction in schizophrenia.     

Sexual deprivation increases ethanol intake in Drosophila

The brain's reward systems reinforce behaviors required for species survival, including sex, food consumption, and social interaction. Drugs of abuse co-opt these neural pathways, which can lead to addiction. Here, we used Drosophila melanogaster to investigate the relationship between natural and drug rewards. In males, mating increased, whereas sexual deprivation reduced, neuropeptide F (NPF) levels. Activation or inhibition of the NPF system in turn reduced or enhanced ethanol preference. These results thus link sexual experience, NPF system activity, and ethanol consumption. Artificial activation of NPF neurons was in itself rewarding and precluded the ability of ethanol to act as a reward. We propose that activity of the NPF-NPF receptor axis represents the state of the fly reward system and modifies behavior accordingly.     

Breakdown of an ant-plant mutualism follows the loss of large herbivores from an African savanna

Mutualisms are key components of biodiversity and ecosystem function, yet the forces maintaining them are poorly understood. We investigated the effects of removing large mammals on an ant-Acacia mutualism in an African savanna. Ten years of large-herbivore exclusion reduced the nectar and housing provided by plants to ants, increasing antagonistic behavior by a mutualistic ant associate and shifting competitive dominance within the plant-ant community from this nectar-dependent mutualist to an antagonistic species that does not depend on plant rewards. Trees occupied by this antagonist suffered increased attack by stem-boring beetles, grew more slowly, and experienced doubled mortality relative to trees occupied by the mutualistic ant. These results show that large mammals maintain cooperation within a widespread symbiosis and suggest complex cascading effects of megafaunal extinction.