Veterinary pharmacovigilance. Part 1. The legal basis in the European Union

Pharmacovigilance is a growing discipline and nowhere is this more true than in the context of the legislative requirements for veterinary pharmacovigilance within the European Union (EU), or more specifically, within the European Economic Area. Since 1995, the legislation governing the authorization of veterinary medicinal products in the EU has resulted in the older national procedures being replaced by the mutual recognition procedure and the centralized procedure. Also since 1995, the regulatory requirements for pharmacovigilance have developed and grown, as have the associated guidelines. The recent review of European veterinary medicines legislation, which concluded with the publication of an amending directive and a new regulation in March 2004, has introduced refinements to the pharmacovigilance system. This paper examines the EU legislation governing the authorization of veterinary medicinal products, including the elaboration of maximum residue limits, and the way in which this relates to the requirements of pharmacovigilance.     

Veterinary pharmacovigilance. Part 2. Veterinary pharmacovigilance in practice -- the operation of a spontaneous reporting scheme in a European Union country -- the UK, and schemes in other countries

Veterinary pharmacovigilance, as it operates in the European Union (EU), covers a very broad remit, including adverse effects in treated animals, exposed humans and the environment, and in addition, it extends to cover the violation of maximum residue limits. The mainstay of veterinary pharmacovigilance is the spontaneous reporting scheme working along side other systems such as those reporting on residues surveillance. One of the most well established schemes in the EU is that operating in the UK and this paper examines the evolution of that scheme and some of its findings, data from other countries, and information available from the literature. It also tentatively examines the ways that pharmacovigilance can be used for regulatory purposes, and the contribution from pharmacoepidemiology.     

Permethrin toxicosis in cats

A retrospective analysis of all adverse experience reports received by the Australian Pesticides and Veterinary Medicines Authority's Adverse Experience Reporting Program for veterinary medicines since 1995, showed that permethrin toxicity in cats usually occurred after the owner applied a canine permethrin-containing product, typically a spot-on. Cats are also at risk from grooming or being in direct contact with recently treated dogs. This paper reviews permethrin toxicosis and its treatment in cats, incorporating information from the Australian and selected overseas veterinary pharmacovigilance programs.     

Pharmacovigilance in veterinary medicine in Chile: a pilot study

Iragüen, D., Urcelay, S., San Martín, B. Pharmacovigilance in veterinary medicine in Chile: a pilot study. J. vet. Pharmacol. Therap. 34 , 108–115. In Chile, there is no present government policy to survey and analyse adverse drug reactions (ADRs) in the field of veterinary medicine. The intent of this study is to assess, for the first time, ADR frequency in treated animals. To this purpose, a 6‐month period pilot study based on WHO recommendations was conducted to monitor ADRs in cats and dogs for frequently used drugs and common labelled signs. Of a total of 149 detected ADRs, 29 (6 in cats and 23 in dogs) were notified by means of ADR report forms, while the rest was identified after reviewing patient clinical records, thus evidencing strong under‐reporting problems. More than 70% of ADRs were related to antimicrobials, vaccines and tranquilizers. In dogs, there was a significant effect on ADRs’ presentation when acepromazine, amoxicillin, carprofen, ivermectin, sextuple vaccine (polyvalent vaccine that confers immunity against canine distemper virus, canine parvovirus, Leptospira canicola, L. icterohemmoragiae, canine adenovirus type 2 and canine parainfluenza virus) and phytomenadione (subcutaneous injection) were administered. In the case of cats, a significant influence on ADRs was detected when acepromazine, amoxicillin or vitamin K was administered. Present results suggest the need for a pharmacovigilance programme in veterinary medicine for timely ADR‐presenting drug detection and drug safety improvement.     

The future requirements and availability of veterinary manpower for New Zealand

Extract

The 1965 Annual Meeting of the New Zealand Veterinary Association endorsed a proposal to examine the future requirement for veterinary manpower in New Zealand. Support was subsequently forthcoming from members of the Association and from organizations interested in veterinary activities in providing data on which estimates could be based. Information was obtained on changes in the numbers of veterinary surgeons and in their employment in the past 15 years and on the estimated requirement for veterinary surgeons at the end of the forthcoming 15 years. A period of 15 years was regarded as one for which records are likely to be reliable and for which projections could be expected to have reasonable accuracy. The examination of data collected in this way forms the first part of this report.     

食品动物兽药残留试验注册资料评审主要内容及常见问题

食品动物使用兽药后,肉蛋奶等动物性食品中兽药残留对消费者可能产生毒害作用,影响人类健康和消费安全,因此,控制动物性食品中兽药残留问题已成为兽药研发和保障食品安全的重要内容。食品动物兽药残留试验资料主要包括兽药最大残留限量标准、兽药残留检测方法标准和休药期确定三个方面内容。本文结合近年来食品动物兽药残留试验注册资料的评审主要内容及常见问题进行综述,旨在为食品动物用兽药的研发与注册提供参考。     

西南部分地区中兽医验方收集分析与典型案例

中兽医是我国优秀的传统文化遗产,但随着近几年畜牧行业的发展和壮大,中兽医传统经方验方传承面临困境.为了改善这种困境,使中兽医更好应用于临床,服务于社会,传承并发扬中兽医学.研究选用问卷调查法,交流访谈法及文献资料法对西南片区中兽医验方进行收集,并对其进行归纳整理、分析,分析了验方来源地分布情况、验方使用时间情况、验方治...     

Pacemaker implantation in dogs: results of the last 30 years

Pacemaker implantation in veterinary practice is still not well known and remains uncommon. However, this technique is the only possible way to cure animals suffering from symptomatic bradycardia whose state does not improve with a medical treatment. In most cases, the use of pacemakers in veterinary medicine leads to the disappearance of the clinical and electrocardiographic signs. This retrospective study concerning the last 30 years draws up an evaluation of the improvements, advantages and drawbacks of this method. Moreover, this study allows the understanding of the evolution of pacemakers' use in veterinary cardiology.     

Length of veterinary working life

Objective To estimate the time veterinary graduates spend in private practice and in veterinary work generally, and to determine what factors influence this.
Methods Questionnaires were completed in the sixth year after graduation by 119 veterinarians who had participated in this longitudinal study since starting the veterinary course, and the data were analysed using the SAS System for Windows.
Results Of those who started the veterinary course, 90% graduated, and 96% of these then entered private practice. Five years later 94% (73% in full-time equivalents) were working as veterinarians, and 64% (50% in full-time equivalents) were still in private practice in Australia. Hours, attitudes of principals and clients, and inadequate rewards were the main reasons for leaving private practice. The likelihood of being still in private practice was greater for those who had had significant responsibility for animals before they entered the course, but it was not related to geographical origin (city vs country), age at entry or gender. Women were, however, more likely than men to be working part time as veterinarians. Predictions of veterinary working life were not affected by geographical origin or by previous experience with animals or on farms, but men expected to work longer than women.
Conclusion The average veterinary career, estimated by veterinarians who graduated 5 years earlier, is 24 years in fulltime equivalents for men, and 16 years for women. Almost all (94%, representing 73% in full-time equivalents) still work as veterinarians after 5 years, most of them (76%, representing 59% in full-time equivalents) in private practice. The likelihood of remaining in private practice is related to previous responsibility for animals.     

Gender and veterinary medicine: global historical perspectives

This essay will suggest research methodologies for historians interested in the history of gender and veterinary medicine over the past 200 years. This topic is a very timely one, because we are currently living through a transition in the interactions between gender and veterinary medicine. Traditionally male-dominated, veterinary medicine has recently experienced a world-wide increase in the number of women entering veterinary schools and practicing in all areas of the profession. Understanding this transition requires us to ask historical, cultural, and sociological questions in order to illuminate the roles of gender ideologies and the participation of women in the development of modern veterinary medicine. The following paragraphs outline three specific methodological strategies that historians have used to study the interactions between gender and science and gender and medicine. I will propose ways that we veterinary historians can use these strategies to study gender and veterinary medicine. It is beyond the scope of this paper to summarize the literature on women and veterinary medicine; but it will nonetheless highlight a few studies from nations around the world to illustrate the methodological strategies that I propose. I hope to provide scholars with ideas for future studies in the history of gender and veterinary medicine.     

新中国成立60年来我国兽医防疫科技事业成就辉煌

回顾了新中国成立60年来,我国兽医防疫科技水平逐步提高,应对突发新的重大动物传染病的快速反应和疾病预防控制能力显著增强,消灭或有效控制了一些长期危害我国的重大动物传染病,兽用疫苗研究开发能力显著增强,取得丰硕成果,动物防控体系和人员队伍进一步健全完备,总结了60年来我国兽医科技事业的辉煌成就。     

欧盟兽药市场发展动态

本文分析总结了欧盟2009至2019年来以猪、牛、绵羊和山羊养殖为主的畜牧养殖业发展动态及相应的兽药市场销售情况,并从欧盟兽药市场具体情况及其在全球兽药市场的地位角度进行了分析,认为欧盟兽药市场以驱虫药和疫苗为主,抗生素和其他兽药为辅。为国内兽药产业从业者了解欧盟兽药市场,以及国内外兽药产业对比提供了具体数据,有助于对国内外兽药产业进行全面的分析。     

200 years of education in veterinary medicine and veterinary activity in Czechoslovakia

The development of veterinary medicine in the Czechoslovak Socialist Republic is evaluated on the occasion of the 200th anniversary of the first lectures on veterinary science at Charles University in Prague (1784). Efforts to found a special veterinary school in Prague date back to the beginning of the 19th century; more than 20 petitions and interpellations concerning the establishment of such a school had been presented to the Bohemian Diet and the Imperial Parliament since 1841. The efforts for the establishment of this school were gradually conjoined with the national-revivalist and national-liberation movement. However, the veterinary university was established only in 1918, in Brno, when Czechoslovakia won independence. The development of veterinary medicine in the territory of today's Czechoslovakia is appreciated positively, mainly in the last 100 years. However, it was only after 1948--in the process of the transition from small-scale farming to large-scale socialist agricultural production--that all the needed practical and economic conditions were created for the development of veterinary medicine. The veterinary service was nationalized in 1951 and adequate material and technical backgrounds were built. Another veterinary university schools was introduced, and post-graduate studies and veterinary extension activities were started.(ABSTRACT TRUNCATED AT 250 WORDS)     

兽药产品批准文号管理新要求及常见问题解析

介绍了近年来文号管理相关制度和技术标准的主要变化，对文号审查中新兽药监测期、比对试验目录产品技术评审标准、特殊产品生产线要求等问题进行了解析。整理汇总了受新制度和技术标准影响的兽药品种，以期为兽药生产企业申请兽药产品批准文号提供参考。     

Virchow's contributions to veterinary medicine: celebrated then, forgotten now

In 1858, Rudolf Virchow, the professor of pathology in Berlin University, published the book "Cellular Pathology". A compendium of his lectures to physicians and medical students, he introduced the use of microscopy for the study of human diseases. To an astonishing extent Rudolf Virchow was helpful to the disciplines of veterinary medicine (and veterinary pathology). Considered a scientific genius in several disciplines, this essay deals exclusively with the devotion of Virchow, a scholarly physician, to the profession of veterinary medicine. He respected veterinary research, supported governmental veterinary education, and provided a role model for the veterinarians who were drafting control legislation of contagious diseases in livestock. Repeatedly, he responded in help when seemingly irretrievable problems arose. Examples of Virchow's activities in the realms of veterinary medicine and pathology are marshalled here to shed light on this pioneer "veterinary pathologist". In celebration of 50 years of the American College of Veterinary Pathologists in 1999, it is timely to remember that Rudolf Virchow, the father of cellular pathology, also fathered veterinary pathology, whose offsprings in Canada and the U.S.A. (Osler, Clement, Williams, Olafson, Jones) had enabled them to form and foster the A.C.V.P.     

A short history of veterinary education in Australia: the 120‐year transition from education for a trade to education for a profession

World Veterinary Year in 2011 celebrates the 250th anniversary of the establishment of the first modern veterinary school at Lyon in France. To put veterinary education in Australia in its historical context, the veterinary school at Lyon was established nine years before the British had discovered the east coast of Australia in 1770, and 27 years before a shipment of convicts transported from overcrowded gaols in England had arrived in Sydney in 1788. This paper discusses the development of veterinary education in Australia from that time to the present day.     

New food safety initiatives in the Food and Drug Administration

Concern over the presence of veterinary drug residues in food has been increasing world wide. Because of this concern the Food and Drug Administration's Center for Veterinary Medicine (CVM) has been involved on an international basis in efforts to develop food safety standards for veterinary drugs. The major thrust of the Codex Committee on Residues of Veterinary Drugs in Foods (CC/RVDF) has been to achieve international agreement on veterinary drugs issues. CVM is an active participant on this committee. The CC/RVDF has established a list of priority veterinary drugs that are, or that have the potential to cause trade problems as the result of public health concerns. Included in this list are anabolic hormones, chloramphenicol, sulfonamides, nitrofurans, nitroimidazoles, somatotropins, benzimidazoles and trypanocides. In the upcoming years, the CC/RVDF will work toward developing international maximum residue levels for these compounds. The evaluation of the toxicity of veterinary drug-bound residues is another area of international concern. In conjunction with the Bureau of Veterinary Medicine, Health and Welfare Canada, CVM is developing guidelines on biological models to demonstrate the safety of veterinary drug-bound residues. In working with veterinary drug regulators from other countries, CVM has new solutions to human food safety problems.     

兽医硕士专业学位研究生教育现状与发展前景分析

通过介绍近年兽医硕士专业学位研究生教育在招生规模、招生对象及培养过程中存在的相关问题,对兽医硕士专业学位研究生教育发展前景进行分析,指出我国教育体制改革、兽医体制改革及社会对兽医人才的需求是影响兽医硕士专业学位研究生教育发展的几个重要因素。     

我国兽医药学科近年研究与应用进展(Ⅰ)

兽药(含饲料药剂)是实现现代养殖的物质基础。本文通过2009与2011年全国10次和11次兽医药理毒理学术研讨会的论文[1,2]综述,介绍兽医药学科技近年研究与应用进展,分为:重要主题,基础药理与临床治疗学,兽药代谢动力学与药物残留,抗菌药与细菌耐药性,中草药及化药新剂型新制剂的研发等5部分。     

中兽医“治未病”学说在动物疾病防治中的应用研究

 中兽医“治未病”理论体系起源于2000多年前的《黄帝内经》,是最早的“预防兽医学”谋略。论文列举了古代医著对“治未病”理论的论述,结合当代中兽医“治未病”的临床实践效果,验证了中兽医“治未病”理论体系的科学性,建议当代集约化养殖应当继承和发扬中兽医“治未病”理念,或许能为防控当今畜禽疾病找到一条新的途径。