Vaccines. Malaria parasite outwits the immune system

Given a few million years of evolutionary practice, the malaria parasite has become extraordinarily proficient at one task: evading the immune system of its human hosts. This it does in four distinct life stages.     

关于加快发展农村经济的若干思考

安徽省是农业大省。如何加快农村经济发展,对整个国民经济发展十分重要。本文就如何加快农村经济发展,从5个方面进行了阐述,可供从事农村工作的同志借鉴。     

加速江苏海洋经济发展的问题思考

分析了江苏发展海洋经济的必要性以及现实意义的基础上,针对当前江苏沿海经济发展中存在的突出问题,提出了加强江苏沿海经济开发的对策建议。     

建立新型农村金融机构风险评价指标体系的探讨

建立一个科学适用的新型农村金融机构风险评价指标体系,是预防和化解新型农村金融机构运行风险的关键。在遵循全面性、准确性、科学性、重要性和灵敏性原则基础上,创建新型农村金融机构风险评价指标体系,可以从内部风险因素和外部风险因素两方面来考虑。运用层次分析法和专家打分法,将河北省新型金融机构面临的内部风险因素和外部风险因素的多层次指标赋予权重,并对各风险指标的风险程度进行排序,进而得出了河北省新型金融机构风险评级指标体系。在此基础上,提出了防范河北省新型金融机构运行风险的对策与建议。     

磐安县加快发展现代农业的对策探讨

分析了磐安县发展现代农业的有利条件和面临的主要问题,提出了磐安县加快发展现代农业的对策措施。     

Microbiology. Turning up the heat on Histoplasma capsulatum

Many fungal pathogens are opportunistic, that is, they infect individuals who have a compromised immune system. Histoplasma capsulatum is a common pathogenic fungus that lives happily inside the phagosomes of macrophages. As Klein explains in his Perspective, an important H. capsulatum virulence factor, CBP1, has been found, which mops up free calcium ions within the phagosome, enabling the yeast to live under calcium-poor conditions (Sebhgati et al.). Chelating calcium ions may also have the added benefit that when the phagosome fuses with the lysosome, destructive lysosomal enzymes that require calcium ions for activity remain inactive.