Safety issues in the exotic pet practice.

Small animal practitioners are well versed in the potential zoonoses from dogs and cats. Although these account for the vast majority of documented cases of zoonotic disease in humans, there are documented as well as potential zoonotic diseases that the nontraditional companion animal is capable of transmitting. This article is a compilation of potential disease risks to veterinarians, staff, and owners of nontraditional companion animals. In addition, the article may serve as a training tool for veterinary practices.     

Equine odontoclastic tooth resorption and hypercementosis affecting all cheek teeth in two horses: Clinical and histopathological findings

This report describes the clinical presentation and histopathological findings of two horses with equine odontoclastic tooth resorption and hypercementosis (EOTRH) affecting all cheek teeth. Equine odontoclastic tooth resorption and hypercementosis is a well documented condition known to affect the incisors, canines and occasionally the premolars in horses. At this time there have been no documented cases of EORTH affecting all cheek teeth described in the peer reviewed literature. This paper documents the first reported cases of EOTRH affecting the cheek teeth in one horse in the United States and one from Germany.     

Clinical remission of idiopathic hypereosinophilic syndrome in a Rottweiler

Idiopathic hypereosinophilic syndrome (HES) is a rare syndrome for which Rottweilers appear to over-represent the canine cases. A 6-month-old female entire Rottweiler presented with seizures following a traumatic incident. The dog was identified as having a marked, sustained eosinophilia and investigations did not identify an underlying cause. Concurrently, the dog had chronic eosinophilic hepatitis with impaired liver function and mesenteric eosinophilic lymphadenitis. The dog went on to have spontaneous resolution of HES and normal liver function was subsequently documented. To date, the dog is still alive, more than 4 years after initial presentation. The diagnosis of idiopathic HES in Rottweilers may not carry a poor prognosis and the condition may spontaneously resolve, even in cases with documented organ damage.     

Feline hippocampal and piriform lobe necrosis as a consequence of severe cluster seizures in two cats in Finland

Feline hippocampal and piriform lobe necrosis (FHN) has been reported from several countries worldwide and is considered an important aetiology for feline epileptic seizures. The aetiology of FHN remains unclear, however it is suspected that FHN might occur secondary to intense epileptic activity as described in humans and dogs although this has not yet been documented in cats. The purpose of our report is to describe the first cases of FHN in Finland diagnosed by magnetic resonance imaging (MRI) and histopathology. The two cases we describe had a well documented history of pre-existing seizures with normal brain MRI at the onset of cluster seizures but MRI done when the cats exhibited clinical deterioration secondary to severe seizure activity, revealed lesions in the hippocampus and piriform lobes typical of FHN. Our report confirms that feline hippocampus and piriform lobe necrosis does occur in the Finnish cat population and should therefore be considered as a differential diagnosis in cats with seizures. In addition, the presentation, clinical findings, results of MRI and/or histopathology shows that cats may develop FHN secondary to severe seizure activity.     

Equine protozoal myeloencephalitis

Equine protozoal myeloencephalitis (EPM) is a disease that produces neurologic signs of brain or spinal cord dysfunction. The causative organism is believed to be a Sarcocystis species of protozoa. A definitive diagnosis can only be made on histopathology of affected spinal cord or brain. No preventive measures or documented treatment is available at this time for suspected cases of EPM.     

Survival of a cat with pneumonia due to cowpox virus and feline herpesvirus infection

Cowpox virus infection in cats is rare and usually leads to cutaneous lesions alone. Pulmonary infection and pneumonia have been documented occasionally but all such cases described to date have been fatal. Although usually affecting the upper respiratory tract, feline herpesvirus can also induce pneumonia. The present report describes the case of a cat that recovered from a pneumonia in which both poxvirus and feline herpesvirus were demonstrated.     

Methiocarb poisoning of a horse in Australia

Snail bait poisoning is rare in horses. Cases have been reported, but clinical signs and subsequent prognostic indicators have been poorly documented and must be extrapolated from cases in companion animals. We describe in detail the poisoning of a horse that consumed a lethal dose of the carbamate, methiocarb. There are currently no guidelines for treating equine methiocarb toxicoses, but the principles of management are based on supportive therapy.     

ULTRASONOGRAPHIC APPEARANCE OF HISTOPLASMOSIS IDENTIFIED IN THE SPLEEN IN 15 CATS

Histoplasmosis is the second most common fungal infection reported in the cat. The disseminated form involving lung, liver, lymph nodes, spleen, and bone marrow is a frequent manifestation of the disease. Limited information is available in the literature regarding the ultrasonographic appearance of the spleen in cats with disseminated or splenic histoplasmosis. A retrospective review of splenic ultrasound images from 15 cats confirmed to have histoplasmosis by splenic aspirates was performed. Size, echotexture, echogenicity, margin appearance, presence of nodules, and the overall shape of the spleen were reported in each case. Splenomegaly was documented in all cases (15/15) and a hypoechoic appearance of the spleen was documented in 14/15 of cases. The spleen was diffusely and uniformly affected in 14/15 (six homogenous and eight with a subtle mottled appearance) and had discrete nodules in 1/15 cats. Histoplasmosis should be included in the differential list for an enlarged and hypoechoic spleen in cats with consistent clinical findings. Additionally, ultrasound guided splenic aspirate may be a useful method to obtain a cytology sample for diagnosis.     

Healing of patellar fractures in two kittens

Two kittens aged between four and five months were presented having sustained patellar fractures. In both cases, healing was subsequently documented radiographically; this has not been reported previously in the literature. One kitten had bilateral patellar fractures - the symptomatic right stifle was treated with a pin and tension-band-wire which later failed, at which point partial patellectomy was performed. The fracture of the left patella was minimally displaced and was treated conservatively. A radiograph of the left patella taken eleven months after initial presentation showed complete healing of the fracture. The second case was treated surgically with a circumferential wire; healing of the fracture was demonstrated radiographically at twelve weeks postoperatively. Radiographic images taken five weeks postoperatively had shown some narrowing of the fracture gap. These two cases demonstrate that bony union of patellar fractures can be documented, given a long enough duration of radiographic follow-up; circumferential wire was an effective treatment in a displaced fracture, and conservative treatment resulted in complete healing of a minimally displaced fracture.     

Osteofluorosis in captive gerenuk (Litocranius walleri) and bongo (Tragelaphus eurycerus isaaci) antelope

Multiple cases of lameness in gerenuk (Litocranius walleri) and bongo antelope (Tragelaphus eurycerus isaaci) associated with high levels of fluoride in a commercial feed are reported. Clinical pathology and histopathology findings are described and the response to treatment is documented. The case highlights the importance of quality control in feed management.     

Tenosynovitis of the carpal sheath of the digital flexor tendons associated with tears of the radial head of the deep digital flexor: observations in 11 horses

Reasons for performing study: Tears of the radial head of the deep digital flexor (DDF) have not previously been documented. Objectives: To describe the presentation, clinical, ultrasonographic and tenoscopic features associated with tears of the radial head of the DDF and to report the results of treatment. Hypotheses: Tears of the radial head of the DDF cause lameness and distension of the carpal sheath of the digital flexor tendons. Removal of disrupted tissue that is extruded into the sheath can result in clinical resolution and restoration of function. Methods: Case records and diagnostic images of horses in which tearing of the radial head of the DDF was diagnosed were reviewed retrospectively and follow‐up information obtained. Results: Eleven cases were identified. Clinical, ultrasonographic and tenoscopic commonality was recorded and treatment techniques were documented. All cases returned post operatively to pre‐injury levels of work. Conclusion: Tearing of the radial head of the DDF is a clinical entity with consistent diagnostic features. Tenoscopic removal of the torn tissue is associated with a good outcome. Potential relevance: Clinicians evaluating lame horses should include tearing of the radial head of the DDF as a differential diagnosis in animals with distended carpal sheaths. Tenoscopic surgery is a recommended treatment.     

Acute poisoning in turkeys caused by incompatibility of monensin and tiamulin

The incompatibility of the anticoccidial monensin and the antibiotic tiamulin when administered simultaneously to chickens is well documented. Signs similar to monensin poisoning have been seen in turkeys given these two drugs together in field cases. This work describes a preliminary trial in which simultaneous administration of therapeutic doses resulted in acute severe poisoning with a high mortality.     

Two cases of paraprostatic cysts in castrated male dogs

Two castrated male dogs presented for evaluation of tenesmus. Presurgical evaluations included complete physical examinations, serum biochemistry, abdominal ultrasonography, and MRI (case 2 only). Paraprostatic cysts were diagnosed in both cases based on the results of abdominal ultrasonography, MRI, and histopathology of tissue samples obtained during exploratory laparotomy. To the authors' knowledge, the two cases presented herein are the first documented cases of paraprostatic cysts that developed after castration in male dogs. Paraprostatic cysts should be considered in the differential diagnoses for castrated male dogs with prostatic disease.     

Two cases of brachymelia in cats

In this report, two cases of brachymelia in related neonatal cats are described. The malformations are described in view of normal limb development, which is illustrated by scanning electron microscopic images. Hypoplasia and aplasia of the distal limb segments were the main disorders in both kittens. Additional malformations in the second case included fusion of the radius and ulna, congenital patella luxation and a shortened tail. Brachymelia and similar cases of feline dysmelia are poorly documented in the existing literature. Possible causes and terminology of these developmental deformations are discussed.     

Meningitis in a dog caused by Prevotella oralis

Prevotella oralis, an obligate Gram-negative anaerobe, was shown to be the cause of meningitis in a two-year-old crossbreed dog. The dog had a six-week history of lethargy and neck pain. On presentation, the animal was reluctant to walk, had a stiff gait and neck pain on flexion. Analysis of cerebrospinal fluid documented a neutrophilic pleocytosis (7488 cells/microl) and the presence of occasional intracellular bacterial coccobacilli. The aetiological diagnosis was confirmed by routine aerobic and anaerobic culture, and identification of the isolates. This report also reviews the literature of the documented cases of bacterial meningitis in dogs.     

Feline eosinophilic granuloma complex(ities): some clinical clarification

PRACTICAL RELEVANCE: The feline eosinophilic granuloma complex (EGC) comprises a group of clinically well recognised but poorly understood dermatoses that are common in cats. In many cases, lesions are severe and can be accompanied by varying degrees of (and sometimes considerable) pruritus and/or pain. In addition, lesions can be chronic and recurrent. It is, therefore, important to achieve a prompt and accurate diagnosis in order to provide optimal, often life-long, treatment for affected cats. PATIENT GROUP: There is no age predisposition or well documented breed predilection for the development of EGC lesions in cats. Some studies have reported a possible female predisposition, but this has not been consistently documented. CLINICAL CHALLENGES: The clinical diagnosis of EGC lesions is usually straightforward, but investigation of the potential underlying aetiology can pose a challenge for the clinician. Information on the indication for various diagnostic tests and their interpretation is lacking, and the tendency for these cases to be managed with chronic medical intervention prior to achieving a definitive diagnosis can further complicate the interpretation of any diagnostic investigation. In addition, successful therapeutic management of these cases can be challenging. Some cats suffer only a single episode of disease that resolves with treatment, while others have recurrent lesions and some of these can be refractory to treatment. The individual variation in both the clinical nature of the disease and the response to therapy could be related to disease severity, but could also be explained by differences in the underlying aetiopathogenesis. EVIDENCE BASE: This article reviews the published literature to discuss the complex aetiology of the EGC and present an overview of the different clinical presentations and diagnosis. A further and particular aim has been to provide some evidence-based recommendations for the management of this unusual group of dermatoses.     

Feline primary open angle glaucoma

Objectives We have documented the histomorphological features of feline primary open angle glaucoma. Design A retrospective morphologic study of eight affected eyes from eight cats, from 1992 to 2006 extracted from a pathology collection, which includes 4000 feline submissions and 1100 cases of feline glaucoma. Procedure Sections of affected globes, stained with H&E or with alcian blue were examined with a light microscope. Eyes that did not fulfill the criteria for primary open angle glaucoma were excluded from the study. Results The mean age was 9.1 years. Five cats were female and three cats were male. The breeds included five DSH, two Burmese, and one DLH cat. Significant histomorphological findings included an open irido‐corneal angle with an open ciliary cleft in all cases, loss of ganglion cells in eight of eight cases, cupping and gliosis of the optic nerve head in four of four cases in which the optic nerve was adequately sampled, and myxomatous changes of the stroma surrounding the vortex veins in seven of eight cases. Conclusions Primary open angle glaucoma in cats is a rare disease that should be taken into consideration when investigating cases of feline glaucoma. The pathogenesis of aqueous outflow obstruction in these cases is not known. This study describes eight additional cases of feline primary open angle glaucoma in cats without an identified cause.     

Protrusion of the Valvular Intestine in Captive Smalltooth Sawfish and Comments on Pristid Gastrointestinal Anatomy and Intestinal Valve Types

Abstract

We report on three separate instances of protrusion of the valvular intestine in the smalltooth sawfish Pristis pectinata, compare pristid gastrointestinal anatomy and intestinal valve structure with those of other elasmobranchs, and discuss the relevance of anatomy and valve structure to the husbandry of captive specimens. Protrusion of the valvular intestine, or intestinal eversion, has been documented in carcharhinid sharks with scroll-type intestines. All three cases of protrusion in smalltooth sawfish in this report involved specimens in multispecies display facilities and ultimately resulted in mortality. These are the first documented cases of intestinal eversion in any species of elasmobranch with a conicospiral valvular intestine. The valvular intestine of sawfishes (family Pristidae) is of the conicospiral type, which is similar to that described in other batoid species. However, unlike many other sharks and batoids, which possess short, stout pyloric stomachs, the pyloric stomachs in the pristids we examined were long and similar to those of carcharhinid sharks. The ability to protrude the valvular intestine in elasmobranchs may depend upon both valve morphology and the length of the pyloric stomach. The details of the gastrointestinal anatomy may be useful for systematics but also may be relevant to the captive husbandry of carcharhinids and sawfishes.     

Equine giant cell tumor of soft parts: a series of 21 cases (2000-2007).

In horses, giant-cell tumors of soft parts are rare neoplasms, with the majority of reported cases occurring within the hind limb muscles and soft tissues in older horses. The following article documents 21 cases of equine giant-cell tumors of soft parts clinically examined within the state of Colorado from 2000 to 2007. The majority of cases occurred in male horses aged 10 years or older. Nine (43%) arose within the hind limbs. Key histologic features included numerous multinucleated giant cells and hemosiderin-laden macrophages admixed with a spindle-cell proliferation. The majority demonstrated liposarcomatous change, variable areas of necrosis and hemorrhage, and an intermediate number of mitotic figures. Immunohistochemical results demonstrated 2 distinct cell populations: vimentin-expressing neoplastic mesenchymal cells and CD18 (histiocytic marker) expressing multinucleated giant cells. These results suggest a mesenchymal origin of the neoplasm with possible recruitment of the secondary histiocytic population. Surgical excision was attempted in the majority of horses and was considered clinically complete. A recurrence of the neoplasm was documented in 1 horse and 1 mule. In 18 horses, surgical excision, regardless of margin integrity, appeared successful with no recurrence of disease documented. Unfortunately, 10 of 21 horses were lost to follow-up within approximately 3 months of surgery. Of the 11 remaining horses that were available for follow-up evaluation, there has been no evidence of metastasis. A larger case series with more controlled follow-up is necessary to evaluate malignant potential and the importance of complete surgical excision.     

Poxvirus infection outbreak in common ringtails (Pseudocheirus peregrinus)

Viruses belonging to the Poxviridae family have long been recognised as pathogens of invertebrates and vertebrates alike. Poxvirus infection in Australian macropodids is well described, but few cases have been documented in marsupial species beyond this family. Only one instance has been previously reported in the common ringtail (Pseudocheirus peregrinus). This case report describes a poxvirus infection outbreak in a group of common ringtails held within a zoological collection in eastern Australia.