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Canine adenovirus pneumonia   总被引:2,自引:0,他引:2  
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犬腺病毒感染   总被引:1,自引:0,他引:1  
犬腺病毒感染是犬的一种病毒性传染病,主要引起犬的肝炎、呼吸道病变及眼睛疾患等。除犬以外,尚可发生于狼、狐、熊等动物。近年来,国内外已证实存在两株相互有关但各具特点的腺病毒:犬腺病毒Ⅰ型(CAV-1)是犬传染性肝炎和狐狸脑炎的病原,且能导致眼睛损伤,而其Ⅱ型(CAV-2)则能引起犬的传染性喉气管炎和幼犬肺炎。  相似文献   

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Veterinary Research Communications - Canine parvovirus type 2 (CPV-2) is one of the most relevant pathogens associated with enteritis in dogs and is frequently reported in association with the...  相似文献   

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Four nine- to 11-week-old puppies developed respiratory and neurological signs due to an infection with canine adenovirus type 2 (cav-2); three of these were euthanased. They had moderate, diffuse pneumonia but there were no histological abnormalities in the central nervous system. Adenovirus-specific nucleic acid was detected by pcr in samples of lung and brain and the amplified product was 99.8 per cent homologous with the cav-2 reference strain Toronto a26/61. The positive pcr result was confirmed by in situ hybridisation in samples of lung, liver and spleen, but not in brain, and cav was isolated in cell culture from lung material; pcrs for canine distemper virus and canine herpesvirus-specific nucleic acids were negative, but large amounts of Bordetella bronchiseptica were isolated from lung material.  相似文献   

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Hypersensitivity reactions to live attenuated and virulent field strains of canine adenovirus can produce renal and ocular disease. The renal lesion is a focal interstitial nephritis which is probably a Type IV hypersensitivity reaction; it has not so far been shown to be of any clinical significance. The ocular lesion, thought to be a Type III immune complex hypersensitivity reaction, is characterized by anterior uveitis and corneal oedema. It is usually transitory but occasionally results in permanent eye defects.  相似文献   

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Canine adenovirus type 1 infection of a Eurasian river otter (Lutra lutra)   总被引:1,自引:0,他引:1  
A 10-year-old female Eurasian river otter (Lutra lutra) died after prolonged anorexia and weight loss in the Seoul Grand Park Zoo, Seoul, Republic of Korea. On necropsy, the liver was found to be swollen and friable with 1 lobe enlarged and necrotic. The other organs showed no significant alterations except for mild atrophy of the right kidney. Microscopically, there was multifocal hepatic necrosis. The hepatocytes around the necrotic areas were swollen and contained large basophilic intranuclear inclusions. Periportal infiltration by plasma cells and lymphocytes was also evident. Transmission electron microscopy revealed characteristic hexagonal virus particles sized approximately 70 nm in diameter in the nuclei of the hepatocytes, which were consistent with an adenovirus. Polymerase chain reaction of the formalin-fixed, paraffin-embedded liver sections was used to determine whether the virus was either the canine adenovirus type 1 (CAV-1), canine adenovirus type 2 (CAV-2), or some other viral agent. The results of these tests showed that the virus was CAV-1. To our knowledge, this is the first report on a CAV-1 infection in an otter.  相似文献   

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Twenty-four Beagle pups with high levels of maternal antibody to canine adenovirus type 1 (CAV-1) and canine adenovirus type 2 (CAV-2) were oronasally inoculated with CAV-2 at 4 weeks of age. The CAV-2 was isolated from pharyngeal swabs on postinoculation days 2 through 6. In spite of the infection, maternal antibody continued to decrease for 4 to 8 postinoculation weeks, and then homologous CAV-2 neutralizing antibody and, to a lesser extent, CAV-1 neutralizing antibody began to increase. When these pups were challenge inoculated with CAV-1 and CAV-2 at a time when maternal antibody to CAV-1 would normally have disappeared, they were immune. In addition, 3 pups with maternal antibody to CAV-1 and CAV-2 were intramuscularly inoculated with CAV-2 at 3 weeks of age. Virus was not isolated from these pups, and maternal antibody decreased at a normal rate. These pups were not immune to challenge inoculation with CAV-1 and CAV-2.  相似文献   

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Forty dogs with canine leishmaniosis (CL) participated in this study, which was designed to investigate the effect of allopurinol on the progression of the renal lesions associated with this disease. The animals were allocated into 5 groups. Group A dogs (n = 12) had neither proteinuria nor renal insufficiency, group B dogs (n= 10) had asymptomatic proteinuria, and group C dogs (n = 8) were proteinuric and azotemic. Two more groups, CA and CB, comprising 5 dogs each, served as controls for groups A and B, respectively. Group A, B, and C dogs received allopurinol PO (10 mg/kg q12h) for 6 months, whereas group CA and CB dogs were placebo-treated. Serum biochemistry profile, urinalysis, urine protein/creatinine ratio, and glomerular filtration rate (GFR) measurements were carried out at the beginning of the study, the 3rd month, and the 6th month, whereas renal biopsies were carried out only at the beginning and the end of the trial. Membranoproliferative glomerulonephritis was the most common cause of chronic renal failure. Mesangioproliferative and tubulointerstitial nephritis were detected even in group A and CA dogs. Allopurinol not only lowered proteinuria in group B dogs but also prevented the deterioration of GFR and improved the tubulointerstitial, but not the glomerular, lesions in both group A and group B dogs. Further, it resolved the azotemia in 5 of the 8 dogs admitted with 2nd stage chronic renal failure (group C). Consequently, treatment with allopurinol is advisable in CL cases with asymptomatic proteinuria or 1st-2nd stage chronic renal failure.  相似文献   

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Canine liposarcoma   总被引:1,自引:0,他引:1  
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Canine pyoderma     
Bacterial skin disease (or pyoderma) is a common canine disorder. It is usually associated with coagulase-positive staphylococci which multiply on skin and induce disease as a result of a number of poorly understood mechanisms. Pyoderma usually occurs as a result of another underlying disorder. Primary causes include hypersensitivity, ectoparasites and metabolic and immunological disorders. A detailed and systematic investigation is mandatory so that the underlying cause is discovered if possible. A number of cases are idiopathic. Pyodermas may be classified according to depth of infection as this affects the type and duration of therapy required and the prognosis. Deeper forms require more aggressive and prolonged therapy. Management of pyodermas depends on the identification and correction of the underlying cause along with adjunct therapy using systemic and topical antimicrobial agents. Idiopathic cases may require protracted or even lifelong therapy with such medicaments. Glucocorticoids are generally contraindicated in the management of pyoderma.  相似文献   

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Canine epilepsy     
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Urine from 237 dogs submitted for euthanasia was collected directly by needle aspiration from the urinary bladder. The bacteriological findings were correlated with the sex and age of the dogs. E. coli was the most frequent species found. The overall incidence of bladder infection was 6–2% for males and 26–6% for females. Bladder infection can be categorized on the basis of occurrence in either very young or in older dogs. The infection incidence increased linearly in bitches older than 4 years, ending at a 50% frequency in those more than 10 years old. Pyometra frequency also increased after 4 years of age and this pattern may indicate a common causative factor for urinary tract infection and pyometra. This investigation shows that subclinical urinary tract infection is common in dogs and is related to age in bitches.  相似文献   

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Hyperlipidaemia refers to an increased concentration of lipids in the blood. Hyperlipidaemia is common in dogs and has recently emerged as an important clinical condition that requires a systematic diagnostic approach and appropriate treatment. Hyperlipidaemia can be either primary or secondary to other diseases. Secondary hyperlipidaemia is the most common form in dogs, and it can be a result of endocrine disorders, pancreatitis, cholestasis, protein‐losing nephropathy, obesity, as well as other conditions and the use of certain drugs. Primary hyperlipidaemia is less common in the general canine population but it can be very common within certain breeds. Hypertriglyceridaemia of Miniature Schnauzers is the most common form of primary hyperlipidaemia in dogs but other breeds are also affected. Possible complications of hyperlipidaemia in dogs include pancreatitis, liver disease, atherosclerosis, ocular disease and seizures. Management of primary hyperlipidaemia in dogs is achieved by administration of ultra low‐fat diets with or without the administration of lipid lowering drugs such as omega‐3 fatty acids, fibrates, niacin and statins.  相似文献   

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