The DairyCHAMP program: a computerised recording system for dairy herds

The DairyCHAMP program is an animal health and management software program that helps daily animal management, herd performance monitoring and problem analysis. Data entry to the program uses a data dictionary and includes an error-checking system that ensures the consistency and appropriateness of data entered. DairyCHAMP performs health management functions, provides a convenient user interface, ensures uniform data across farms by using a standard data dictionary, can be fully integrated with decision-making software programs like DairyORACLE, and is flexible enough to be useful for many types of dairy facilities. Data are entered via a menu-based system. Animal events are organised around reproduction and lactation cycles and health records. Farm records include inventories for drug, feed and semen. Farm parameters can be established which customize the program for an individual farm. The database system is an integration of three schemas: the individual user's view, the community view and the storage system. The individual user's view must be easy to use, while the storage system must be compact enough to fit within the disc storage space on a microcomputer. This conflict requires a translation from one schema to another. The DairyCHAMP program accomplishes this through a coding system which assigns a code number to each event. The program can add synonyms to this event dictionary by assigning the same code number to the synonym the user chooses. The DairyCHAMP program provides access to the large amounts of data required to aid in daily animal management, allow performance monitoring and analyse problems. Its highly integrated system is efficient and easy to use and maintain.     

Use of Body Surface Area (BSA)-Based Dosages to Calculate Chemotherapeutic Drug Dose in Dogs: I. Potential Problems with Current BSA Formulae

The dose of most cancer chemotherapeutic drugs administered to dogs is calculated on the basis of estimated body surface area (BSA); however, results of some chemotherapy trials have revealed that this dosing method increases toxicosis in small dogs. The current formula used to estimate BSA in dogs may be inaccurate or the assumption that BSA correlates with chemotherapeutic drug exposure may be unfounded. Results presented in this review suggest that canine BSA estimates may be inaccurate because the values for the constant (K) and exponent (a) in the formulae (BSA = K.W^a) are incorrect or because a linear parameter such as body length is lacking from the formulae. Results that suggest the relationship between BSA and the physiologic/pharmacologic factors that influence drug exposure may not be closely correlated are also presented. Studies are warranted to determine whether there are dosing methods that normalize chemotherapeutic drug toxicity in dogs.     

Multiple regression analysis, using body size and cardiac cycle length, in predicting echocardiographic variables in dogs

A significant (P less than 0.0001) positive correlation was demonstrated between left ventricular internal chamber dimension in diastole or systole and body weight, body surface area, cycle length, and the square root of cycle length. On the basis of adjusted coefficients of determination, multiple regression analysis, using body weight or body surface area and cycle length or the square root of cycle length, was superior to separate simple regression with these variables in accounting for variations in left ventricular internal chamber dimensions. Shortening fraction had a significant (P less than 0.0001) negative correlation and left ventricular free wall measurements had a significant (P less than 0.0001) positive correlation to body weight and body surface area. For these echocardiographic variables, correlation to the square root of cycle length was insignificant (P greater than 0.05), and a multiple regression model was not helpful in developing confidence intervals. Septal wall measurements were not correlated with body weight, body surface area, cycle length, or the square root of cycle length.     

Profitability of Carbon Sequestration in Western Rangelands of the United States

Concerns over climate change have increased interest in carbon sequestration in agricultural lands. While the per-hectare carbon capture potential of rangelands is less than either cropland or forests, existing research suggests modest changes in carbon storage on rangelands can potentially alter the global carbon cycle. This paper examines the potential firm-level revenues from voluntary carbon offset programs, such as the Chicago Climate Exchange (CCX) Rangeland Soil Carbon Offset program. We estimate revenues for short-term voluntary offsets given historical prices and prices projected with potential cap-and-trade legislation. We also estimate revenues assuming 100-yr offsets are required to meet international sequestration standards. Simulation results indicate a relatively wide range of modest revenues from recent CCX contracts and carbon prices. The analysis suggests that recent carbon prices or low-end projected prices from cap-and-trade legislation are not likely to encourage producer participation. Medium and high carbon price projections for cap-and-trade legislation may make carbon sequestration a more attractive option for rangeland managers, but given potential requirements for projects to meet international guidelines for greenhouse gas offset projects, many issues remain before range managers may be interested in carbon sequestration as an enterprise.     

Pharmacokinetic properties of doxorubicin encapsulated in glutaraldehyde-treated canine erythrocytes.

Canine erythrocytes were loaded with the antineoplastic drug doxorubicin and then treated with 0.16% glutaraldehyde. This procedure has been previously shown to slow down the efflux of doxorubicin from erythrocytes and to result in the selective targeting of the carrier erythrocytes to liver. Three dogs were treated each with 2 different schedules of IV bolus administration of doxorubicin (0.4 mg/kg of body weight): free drug and doxorubicin encapsulated in glutaraldehyde-treated erythrocytes. The 2 treatments yielded consistent differences in the plasma pharmacokinetic properties of doxorubicin and of its only metabolite, doxorubicinol. A triphasic exponential decay of doxorubicin plasma concentrations was observed on injection of the free drug. Conversely, in the case of erythrocyte-encapsulated doxorubicin, 4 phases of plasma concentrations of doxorubicinol were found. The plasma concentrations of doxorubicinol, after a steady increase during the first hour, followed patterns of decay comparable to those of the parent drug. On the basis of the kinetic variables calculated with the 2 administration schedules, area under curve concentrations of plasma doxorubicin were 136 micrograms.h/L (free infusion) and 734 micrograms.h/L (erythrocyte-encapsulated drug). Significant alterations of hematologic and hematochemical factors were not observed in the 3 dogs during and after the 2 treatments. On the basis of our findings, doxorubicin-loaded and glutaraldehyde-treated erythrocytes may potentially be used in the treatment of systemic and hepatic tumors in dogs.     

Pharmacokinetic estimation for therapeutic dosage regimens (PETDR) – a software program designed to determine intravenous drug dosage regimens for veterinary applications

Pharmacokinetic estimation for therapeutic dosage regimens (PETDR) is a soft-ware program used to design individualized intravenous dosage regimens, determine concentration-time profiles, predict serum concentrations at a specific time after intravenous dosing and predict the time after the last dose to achieve a specified concentration of drug. The reference pharmacokinetic parameters may be based on an individual animal's pharmacokinetic disposition of drug or on FARAD (Food Animal Residue Avoidance Databank) mean population kinetic parameters. An individual animal's kinetic parameters may be input for predetermined analysis or the program can calculate these values by input of raw serum concentration-time data. The program allows the user to specify certain parameters of the dosage regimen, then calculates the other parameters (given desired maximum and minimum serum concentrations, dose and interval are calculated; given desired maximum serum concentration and interval, dose is calculated, etc.). Given the kinetic parameters, the dose and dosing interval, the program calculates and plots the serum concentration-time profile of the drug for that animal. The time and the number of doses to reach steady state can be calculated as well as the determination of loading dose. The percentage of the time of a dosing interval at steady state that the serum concentration is above a specific minimum inhibitory concentration (MIC) allows evaluation of efficacy of an antimicrobial regimen. Similarly, the time to reach a specific concentration (e.g. residue tolerance) or the MIC of a drug can be calculated. Legal tissue tolerances can be accessed from FARAD to aid in predicting for what period of time illegal residues will remain in the animal.(ABSTRACT TRUNCATED AT 250 WORDS)     

论重庆涪陵地名的命名类型及文化意义

一个地方的命名总有其根据，或依据自然因素，或依据人为因素，一个地名要么反映了该地的自然特征，要么反映了该地的人文特点。涪陵地名的通名主要以地理形态特征、建筑物和行政区划为命名依据，专名主要以地理形态特征、动植物、姓氏、生产活动、历史故事人物、宗教传说等为命名依据，文章从命名依据中探究了地名所蕴涵的文化意义。     

The relationship between oxygen consumption, body temperature and surface area in the hatching and young chick

There is an increase in the effective surface area of the chick at hatching and this is accompanied by an increase in the oxygen consumption so that there is little change in the oxygen uptake per square centimetre. This results in the body temperature of the chick being maintained at its prehatching level.

The body temperature of the chick rises for six days after hatching. This appears to be due to the progressive replacement of the yolk with actively metabolising tissue resulting in the active mass of the bird increasing at a greater rate than the effective surface area.

The oxygen consumption (ml./g./hr.) continues to rise after the body temperature becomes constant which suggests that there is an increase in the metabolic rate after hatching.     

Use of factor scores for predicting body weight from linear body measurements in three South African indigenous chicken breeds

Body weight and weight of body parts are of economic importance. It is difficult to directly predict body weight from highly correlated morphological traits through multiple regression. Factor analysis was carried out to examine the relationship between body weight and five linear body measurements (body length, body girth, wing length, shank thickness, and shank length) in South African Venda (VN), Naked neck (NN), and Potchefstroom koekoek (PK) indigenous chicken breeds, with a view to identify those factors that define body conformation. Multiple regression was subsequently performed to predict body weight, using orthogonal traits derived from the factor analysis. Measurements were obtained from 210 chickens, 22 weeks of age, 70 chickens per breed. High correlations were obtained between body weight and all body measurements except for wing length in PK. Two factors extracted after varimax rotation explained 91, 95, and 83 % of total variation in VN, NN, and PK, respectively. Factor 1 explained 73, 90, and 64 % in VN, NN, and PK, respectively, and was loaded on all body measurements except for wing length in VN and PK. In a multiple regression, these two factors accounted for 72 % variation in body weight in VN, while only factor 1 accounted for 83 and 74 % variation in body weight in NN and PK, respectively. The two factors could be used to define body size and conformation of these breeds. Factor 1 could predict body weight in all three breeds. Body measurements can be better selected jointly to improve body weight in these breeds.     

Economic evaluation of the production impact of bovine schistosomiasis and vaccination in the Sudan

This study was done to evaluate the estimated economic consequences of the recent discovery that an irradiated Schistosoma bovis vaccine was effective in reducing mortality and intensity of infection in cattle after field exposure to S. bovis in the White Nile province. The benefits and costs were hypothesized to occur over a 5-year period starting after the vaccine had been further developed to optimal commercial usefulness.

The potential benefits of vaccination are from the avoidance of mortality and growth delay losses caused by S. bovis infection and were based on an owner survey conducted in 1981. These benefits were discounted from the time of their potential marketing opportunity to the first year of a vaccination program at 15% per annum and were valued on a basis of 1982 prices for live cattle exported to Egypt and Saudi Arabia. Variations in benefits stem from degree of infection probability, mortality and morbidity estimates and percent of animals vaccinated. Since clinical schistosomiasis (“gorag” — sunken-eyed appearance) and associated production losses occur almost exclusively in 6- to 30-month-old cattle, and there is evidence for long-term immunity, vaccinations would be given to cattle in this age-specific group or younger once in their lifetime. The principal variation in vaccination program costs, also valued at 1982 prices, is from vaccine production costs; $0.50 or $4.00 per dose. A vaccine efficacy of 70%, observed in a previously reported field trial, was used in these calculations.

Present value benefit—cost (b–c) ratios were estimated for the central, western and southern areas for high- and low-level effects of S. bovis impact on production and the vaccination program, cost and effectiveness. In an area (central provinces) of high infection probability (90%), high percentage of animals vaccinated (90%), high mortality (7.1%), and low vaccine production costs, the b–c ratio was 12.7. In contrast, a b–c ratio of 0.7 was estimated for an area (southern provinces) assuming low infection probability (50%), low percent of animals vaccinated (50%), lower mortality (3.55%) and high vaccine production costs. Potential returns from increased future milk and calf production and from faster herd build-up with younger females were not included in these benefit calculations. These results indicate that under most conditions further development of the vaccine and cost-effective vaccine production techniques would yield very favorable returns from improved livestock production efficiency in the Sudan. Export prices were assumed to not vary significantly with increased supply of export-quality cattle resulting from the estimated production losses avoided by vaccination against schistosomiasis.     

Morphological investigation of carotid body and its arteries in rabbits

The purpose of this study was to determine the morphology of the rabbit carotid body and its artery at the light microscopy level. The carotid body was situated between the internal and external carotid arteries after the bifurcation point of the common carotid artery. The carotid body was usually found to be a single, ovoid tissue mass but, in some cases it consisted of two or three parts. More carotid bodies were supplied by a single carotid body artery (glomic artery) which arose from the common carotid artery or the internal or external carotid arteries near the bifurcation point of the common carotid artery. In only one case were there two arteries which arose from opposite sides of the external carotid artery at its origin. There was a distinguishable sinus (glomic sinus) at the origin of the glomic artery. This artery had a thin wall with elastic laminae in the sinus area which become thinner distal to the sinus.     

Effect of breed on body composition and comparison between various methods to estimate body composition in dogs

The objectives of this clinical study were firstly, to assess the effects of breed/genetic group on body composition in dogs using Dual-X-ray absorptiometry (DEXA) as the reference method and secondly, to check, in clinical field conditions, if methods easy to apply in veterinary practice [bioelectrical impedance (BIA), morphometric equations, body condition score and body mass index] can give similar body composition results to DEXA results, using canine breeds with very different genetic and morphologic backgrounds. 19 dogs from 6 breeds with different genetic origin were used. Results showed that breed differences exist regarding body composition in dogs. Body condition score and morphometric equation should be developed by breed or by groups of breeds for an accurate estimation of body composition of the various breeds of dogs with a different genetic background or morphology. Any of the other tested methodologies (BIA or morphometric equations) gave results in agreement with DEXA value, when dogs with different genetic background and morphologic characteristics are used, but BIA, eventually in combination with morphometric measurements, could be a method to develop to estimate fat-free mass in dogs of different breeds.     

Malassezia species isolated from the intermammary and preputial fossa areas of horses

BACKGROUND: Malassezia-type yeasts previously have been observed on cytologic examination of the intermammary region of mares that presented with tail-head pruritus; topical antiyeast treatment resolved the pruritus. Further, Malassezia dermatitis has been observed in horses in intertriginous areas such as the udder and prepuce; the species of yeast was not confirmed. It is not known whether healthy mares or male horses can be carriers of this yeast in these body areas. HYPOTHESIS: Malassezia spp. are present in the intermammary region in healthy mares and the preputial fossa in healthy geldings. ANIMALS: Eleven healthy horses (5 mares and 6 geldings). METHODS: Samples of surface material were taken digitally from the intermammary area of 5 mares and the preputial fossa region of 6 geldings. The samples were examined cytologically and were cultured on modified Sabouraud's dextrose agar. The DNA from yeast colonies grown on the agar was extracted, and samples were assayed using fungal generic polymerase chain reaction (PCR) analysis. Amplicons with positive PCR results were sequenced and compared with sequences in the BLAST database search program. RESULTS: Of 44 attempts at culture, 5 yielded a species identified as Malassezia equi, and 2 yielded M slooffiae. In contrast, of 44 cytologic examinations, yeasts with the morphology of Malassezia spp. were seen in 40 samples. CONCLUSIONS AND CLINICAL IMPORTANCE: Due to its presence in healthy horses, finding of Malassezia-type yeast on cytologic examination may not incriminate it as a pathogen. Despite difficulty in culturing, cytologic examination was an effective tool to rapidly demonstrate the organism.     

The Confusion of Common Names: A Methodological Challenge

The problem of dueling names for a species has been minimized within the scientific community through the development and use of standardized ordering and naming systems. Ambiguity, however, persists among common vernaculars. Such variation in names transcends countries and continents, and can result in a single species being known by multiple names in the same area, a single species being known by different names in neighboring communities, or many species being known by one name. As part of a group-administered survey regarding wildlife, we asked 932 Tanzanian primary school children to name the species represented by animal illustrations. Participants provided up to 37 different names for each species (M = 19.8, SD= 13.3). Determining if the names indicated familiarity with the species proved challenging. Our results highlight the complications common names can cause for human dimensions of wildlife researchers.     

家蚕蛹数量型体征值间关系的研究

根据蚕茧大小将蚕蛹分组,测其质量、体表面积等值,利用国际标准统计软件SAS的REG、GLM、NLIN过程处理数据。结果表明,蛹体质量与体表面积、相对体表面积特征值间均存在极显著的指数关系,如:质量与体表面积间呈正相关,决定系数达0.8717,模型为y=4.9265xe-0.2288x;质量与相对体表面积间呈负相关,决定系数达0.9493,模型为y=8.9331xe-0.8746x。即蛹体表面积随质量增加而变大,相对体表面积反而变小。其次,纵、横幅、体积等各特征值间的一元关系,质量、体积与纵、横幅,体表面积与纵幅、体积间的多元关系也都达显著或极显著水平。     

Concept and realization of a multimedia program for veterinary physiology

A multimedia program, a non-linear system which supplements the traditional, linear way of learning (e.g. with a text book), was developed. Non-linear systems allow the direct use of information in a free sequence. A problem of these systems is the danger that the reader becomes lost in detail. Therefore, a program was constructed which tries to combine the properties of linear and non-linear teaching systems. Student groups were continuously involved during all stages of the project. The program is organized in several levels. These are: (1) choice of chapters; (2) table of contents of one chapter; (3) summary; (4) text and (5) pictures, animations, simulations and video sequences. The program can be used in different ways. In the linear mode, the reader selects via action words different levels of the program. The user can read either only on the level of the summaries or on detailed information (text, pictures, simulations and videos). In the non-linear mode the user jumps via menu items or buttons to selected pictures, simulations or a searched term. In this way, more than 3500 screen pages are integrated into a multimedia program for veterinary physiology. The program is written in TOOLBOOK, and can be used on a personal computer with Windows 95 or higher.     

德昌水牛母牛体重体尺的相关性与回归分析

对德昌水牛95头生长发育母牛的体重与体尺指标进行相关分析,得出其体重与胸围、体长的相关系数达到0.9209和0.5788;经逐步回归分析法建立了最优回归方程：体重（y）=-737.381＋432.772×胸围＋262.598×体斜长,为早期考察德昌水牛生长发育情况提供了依据。     

Allometric basis of enrofloxacin scaling in green iguanas

When body size varies greatly, drug disposition can best be described as an allometric function of body weight. Therefore, the allometry of standard metabolic rate (SMR; 3/4 power) and body surface area (BSA; 2/3 power) have been advocated as surrogate markers for the prediction of key pharmacokinetic parameters. The goal of the present study was to examine the allometric basis of pharmacokinetic scaling within a species, green iguanas. Enrofloxacin was administered intravenously to 20 green iguanas (322-3824 g), and noncompartmental analysis was used to calculate standard pharmacokinetic parameters, which were log(10) transformed and regressed against log(10) body weight. The slopes of significant regressions were compared with the values of unity, 3/4, and 2/3. The slope of enrofloxacin total body clearance (Cl) was also compared with the slopes relating SMR and renal Cl of (99m)Tc-diethylenetriamine penta-acetic acid ((99m)DTPA) to body weight in iguanas. Enrofloxacin Cl depended allometrically on body weight with the power of 0.32. The slope of enrofloxacin Cl was significantly less than those of SMR, Cl of (99m)DTPA, and the 2/3 value. Therefore, the relationship between enrofloxacin Cl and body weight does not directly depend on the allometry of BSA, SMR, or renal Cl of (99m)DTPA in iguanas.     

CRITTER: A database for managing research animals

We describe CRITTER, a computer database program for managing research animals. We designed it especially for institutions which operate health surveillance plans, such as specific pathogen-free schemes. Because CRITTER can be used to record any type of test result in any species of animal, it can be customized to suit each institution and its management protocol. In addition to maintaining a current inventory of each individual animal and its location, the program retains historical information on those that have been removed from the colony. Output summaries are generated by selecting from a menu of standard reports or by designing a custom query. Although CRITTER has been designed for individual research establishments, it could be modified for use in area health surveillance programs. CRITTER operates on IBM compatible computers using a menu-driven, runtime version of Paradox.