Tech.Sight. Gene therapy. Hurdles and hopes for cancer treatment

Remarkable progress has been achieved in the field of gene therapy over the past decade. The initial excitement in this young field has led to the development of more than 500 gene therapy protocols approved for evaluation in clinical trials. As these clinical trials progress, many obstacles have been identified that investigators in the field will need to overcome. Among the most important areas of investigation in the field of cancer gene therapy are 1) development of novel vectors to improve gene delivery, 2) development of tumor-selective binding to improve specific tumor targeting, and 3) improvement of the therapeutic window to reduce the toxicity of gene therapy administered alone or in combination with conventional agents. The challenge is not to replace current strategies for cancer therapy with gene therapy but to incorporate gene therapy as a more rational, molecularly based approach to increase our therapeutic armamentarium.     

蜕皮激素类似物美满防治甜菜夜蛾田间药效试验

蜕皮激素类似物美满(methoxyfenozide)对甜菜夜蛾(Spodoptera exigua Hubner)有突出的防治效果,田间使用24%美满悬浮剂3 000倍、6 000倍,药后1天、3天、7天防治效果分别达到93.42%,97.05%,98.39%和82.61%,88.87%,89.38%,与10%除尽(chloffenapyr)1 500倍相当.美满与乐斯本(chlorpyrifos)混配使用,也可以达到理想的防治效果.且能节约用药成本,在作物生长前期可适当使用.仿生的蜕皮激素类似物是当前无公害蔬菜生产中值得推荐的好农药.