共查询到20条相似文献,搜索用时 15 毫秒
1.
Nofrarías M Manzanilla EG Pujols J Gibert X Majó N Segalés J Gasa J 《Journal of animal science》2006,84(10):2735-2742
We evaluated the effects of a 6% spray-dried porcine plasma (SDPP) and a plant extracts mixture (XT; 5% carvacrol, 3% cinnamaldehyde, and 2% capsicum oleoresin) on the productive performance, intestinal morphology, and leukocyte cell subsets of early-weaned pigs compared with a control group. Morphometry of the jejunum, ileum, and colon, and immune cell analysis of blood, ileocolic lymph node (LN), and ileal Peyer's patches were done in 24 weaned pigs (20 +/- 2 d) at 19 or 21 d postweaning. Although SDPP and XT treatments did not increase ADG or ADFI, SDPP improved the G:F ratio (P = 0.024) compared with the control group. Dietary SDPP reduced the percentages of blood monocytes (P = 0.006) and macrophages in ileal Peyer's patches and LN (P = 0.04), of B lymphocytes (P = 0.04) and gammadelta+ T cells in LN (P = 0.009), and of intraepithelial lymphocytes (P = 0.026) as well as the density of lamina propria cells in the colon (P < 0.01). Dietary XT reduced intraepithelial lymphocyte numbers in jejunum (P = 0.034) and the percentages of blood cytotoxic cells (P = 0.07) and B lymphocytes in LN (P = 0.03); however, XT increased blood monocytes (P = 0.038) and the density of lamina propria lymphocytes in the colon (P = 0.003). These results indicate that dietary SDPP and plant extracts can affect intestinal morphology and immune cell subsets of gut tissues and blood in weaned pigs. Furthermore, the effects of SDPP suggest lower activation of the immune system of the piglets. 相似文献
2.
Twenty four, 21-d-old female pigs were fed diets containing either skim milk powder (CON+), spray-dried bovine colostrum (7.5%, BC+) or spray-dried bovine plasma (7.5%, BP+) and were dosed orally with 1 × 109 CFU of E. coli O149:K88. Another group of 8 unchallenged pigs was fed the skim milk powder diet (CON−). On d 19 of the experiment all piglets were euthanased. Adverse effects of the E. coli challenge were observed variously throughout the small intestine in pigs consuming either the BC+ or BP+ diets. In this experiment, similar responses to the E. coli challenge were observed in both plasma and colostrum fed pigs, which suggests that spray-dried bovine colostrum may be a potential alternative to spray-dried bovine plasma. 相似文献
3.
We investigated the effect of potato starch, a source of resistant starch (RS), in diets for newly weaned pigs on production of short chain fatty acids (SCFA) and intestinal morphology. At weaning, at 4 weeks of age, 24 pigs were divided into 3 groups and fed diets containing 0 (C), 80 (P80) or 160 (P160) g raw potato starch per kg feed for 12 days. Pigs fed P160 had the longest villi whereas pigs fed P80 had the deepest crypts. Villous height at the mid-small intestine and average daily gain were positively correlated (r = 0.59, P < 0.01). The daily gain tended to be lower (P = 0.08) for pigs fed P80 than for pigs fed C or P160. The colon weight increased in pigs fed RS which coincided with an increased crypt depth in the colon. The concentration of SCFA increased in the large intestine with increasing amount of RS. The proportion of acetic acid decreased and the proportion of butyric acid increased in pigs fed P80 and P160. The increased SCFA production, especially of butyrate, may explain the colonic growth. 相似文献
4.
An experiment was conducted to evaluate the effects of dietary spray-dried bovine and porcine plasma and spray-dried bovine colostrum on growth performance and intestinal histology in weaner pigs. Thirty-two 21-day-old piglets (6.65 ± 0.14 kg) were allocated to receive one of four dietary treatments: control, bovine plasma, porcine plasma, and bovine colostrum at weaning and another 8 piglets were killed at weaning to provide baseline data. The experimental diets were offered ad libitum for one week, after which animals were killed and post-mortem measurements obtained. No differences in average daily feed intake and growth rate were observed among dietary treatment groups (P > 0.05). Baseline piglets had taller villi and shallower crypts (P < 0.05) in the proximal jejunum, mid jejunum and distal ileum than those observed a week after weaning, irrespective of dietary treatment. Weaning-related expansion of intestinal lamina propria CD4+ and CD8+ T lymphocyte populations was observed (P < 0.05). Complex and variable treatment effects on villus height, crypt depth, villus and crypt goblet cell density, and lamina propria T cell density were observed, suggesting that the tested protein sources do not share a common or simple mode of action. 相似文献
5.
试验旨在探索对仔猪床进行加温处理以及采用定时饲喂的方式的对早期断奶仔猪不同肠段黏膜形态和肠道发育的影响,从而为确定断奶仔猪适宜的饲养温度和科学的饲喂方式提供理论依据。试验采用2×2因子设计。选用21日龄杜长大断奶仔猪240头,随机分到4个处理组:1):28~30℃的仔猪床加温处理组;2)23~25℃的低温对照组(炉火暖气管道舍内加热);加温处理组和低温对照组中又根据不同的饲喂模式分为每天6次定时饲喂组和自由采食组。每个处理6个重复,每个重复10头猪。经过14 d的试验之后,在每圈仔猪中随机抽取1头,屠宰后取样检测小肠黏膜的绒毛高度、隐窝深度和肠壁厚度。结果表明:加温饲养组(28~30℃)的仔猪空肠中段的绒毛高度显著高于低温对照组(23~25℃)(P<0.05)。加温饲养组十二指肠的隐窝深度和空肠中段的肠壁厚度显著低于低温对照组(P<0.05)。定时饲喂饲养的仔猪空肠后段的绒毛高度显著高于自由采食饲养的仔猪(P<0.05)。定时饲喂组仔猪空肠中段的肠壁厚度和十二指肠隐窝深度显著低于自由采食组(P<0.05)。2因子的互作效应表明:加温定时饲喂组饲养的仔猪空肠后段的绒毛高度显著高于其他处理组。低温自由采食组饲养的仔猪空肠后段的绒毛高度极显著低于其他处理组(P<0.01)。加温定时饲喂组的仔猪空肠中段的肠壁厚度极显著低于其他处理组(P<0.01)。由结果可知,28~30℃的加温饲养组以及定时饲喂的饲喂模式有利于仔猪的肠道黏膜形态的改善,有益于肠道的发育和健康。 相似文献
6.
D. Martinez-Puig E.G. Manzanilla J. Morales E. Borda J.F. Prez C. Pieiro C. Chetrit 《Livestock Science》2007,108(1-3):276-279
In the weaning period, transition from sow's milk to the post-weaning diet causes the withdrawal of important nutrients as milk nucleotides, which are known to be determinant for the development of the gastrointestinal tract and immune function. The objective of these investigations was to study the effect of including these nucleotides in solid diets for piglets. Nucleotide composition of sow's milk was analyzed using 5 sows at 21 days of lactation. The average free nucleotide concentration was 102.8 ± 9.16 μmol/100 mL. Two experiments were performed to assess the effect of a product based on this composition (Nucleoforce Piglets®) on digestive adaptation and incidence of diarrhoea of nursery piglets. In Exp. 1, three groups of 6 piglets were weaned at 21 days of age and fed with a diet supplemented with 0 (control), 1000 or 2000 ppm of nucleotides, and a fourth group of 6 piglets was maintained in lactation. Seven days after weaning, piglets were euthanized and samples of jejunal mucosa were processed for histological measurements. Villus height decreased from 448 μm in un-weaned pigs to 275 μm in the control group 7 days after weaning. Although there were no differences in feed intake among groups, the reduction in villous height was less pronounced (P < 0.001) in nucleotide supplemented groups showing a villous height of 351 and 378 μm with the doses of 1000 or 2000 ppm respectively. In Exp. 2, 384 early weaned pigs were fed during 14 days with a diet supplemented with 0 (control), 750 and 1000 ppm of nucleotides. ADG and ADFI were not modified by the treatment, but nucleotide supplementation reduced the number of pigs treated with antibiotic as a result of diarrhoea (15.63% vs 3.13% and 1.56%; for control, 750 and 1000 ppm; P < 0.001). These results suggest that dietary supplementation with nucleotides from yeast might help to prevent post-weaning diarrhoea in piglets. 相似文献
7.
L. Casini S.R. Kostantinov F. Coloretti S. De Filippi M. Mazzoni P. Trevisi P. Bosi 《Livestock Science》2007,108(1-3):226-228
Not nocuous bacteria are important for the maturation and the modulating activity of the gut immune system. However, the humoral immune response against commensal and probiotic bacteria is less documented, particularly in farmhouse animals. Blood serum and saliva were collected in two trials where probiotics, Lactobacillus rhamnosus GG (LbR), well-defined human isolate (Trial A), and a novel and abundant porcine commensal, Lactobacillus sobrius strain 001T (LbS) (Trial B), were supplemented to weaning pigs. Anti-LbR IgA were present in serum of pigs before treatment with LbR, but also after 1 or 2 weeks in control pigs, notwithstanding the absence of DNA from LbR in colon. Pigs fed or not LbS for 1 or 2 weeks had LbS-specific IgA, in saliva and in serum. Colon contents of control subjects were positive for DNA from LbS. We hypothesized that part of this IgA strain-specific activity is partially related to immune cross-reactivity between different Lactobacillus-species. With the procedure of Shu et al. [Shu, Q., Bird, S.H., Gill, H.S., Rowe, J.B., 1999. Immunological cross-reactivity between the vaccine and other isolates of Streptococcus bovis and Lactobacillus. FEMS Immunol. Med. Microbiol. 26, 153–158], after ELISA test on blood serum or saliva pre-incubated with LbR or LbS, each strain blocked a relevant part of IgA specific for the other. So bacteria with different affinity for the pig present reciprocal crossed immune activity. When probiotics are supplied to weaning pigs, the possible action of already present multi-effective IgA should be considered. The mechanism of IgA induction by certain probiotics needs to be addressed in further studies. 相似文献
8.
旨在研究基础日粮中添加不同水平的斜发沸石对苏淮育肥猪血液生化指标、肠道形态的影响,为斜发沸石在苏淮猪生产中的应用提供数据参考。选择体重(50±2)kg、健康的苏淮阉公猪40头,随机分为对照组、试验Ⅰ组、试验Ⅱ组、试验Ⅲ组共4个处理组。试验预饲期10 d,所有猪自由采食对照组基础日粮;正试期64 d,对照组饲喂基础日粮,试验Ⅰ至Ⅲ组分别在基础日粮中添加0.5%、1.0%、2.0%的斜发沸石。结果:随斜发沸石水平增加,血清免疫球蛋白G(IgG)、肠道黏膜分泌型免疫球蛋白(sIgA)和肠道黏膜IgG含量升高。随斜发沸石水平增加,血清碱性磷酸酶含量升高;血清甘油三酯含量先升高后降低。随斜发沸石水平增加,平均红细胞血红蛋白浓度含量升高;红细胞分布宽度变异系数降低。随斜发沸石水平增加,十二指肠隐窝深度降低;空肠绒毛高度和空肠段绒毛高度/隐窝深度有升高的趋势。试验表明,在各组日粮消化能和粗蛋白均满足且一致的情况下,添加适宜比例斜发沸石对改善猪的机体血液及肠道免疫功能有积极作用。综合考虑以上检测指标变化规律及斜发沸石添加成本,建议斜发沸石的适宜添加比例为1.0%。 相似文献
9.
Linseed as a feed ingredient contains a number of constituents, such as mucilage, gel forming polysaccharides, structural carbohydrates and ω-3 fatty acids, which could have functional properties in relation to maintaining and supporting gastro-intestinal health in post weaning piglets. Intestinal gene expression was studied in weanling piglets fed diets containing either or not linseed or linseed expeller meal. Piglets were either or not orally challenged with an enterotoxigenic strain of E. coli K88. Pairwise comparisons identified several mRNAs expressed significantly different, in particular between treatments C− (control, not challenged) and LS− (linseed, not challenged) and LS+ (linseed, challenged) and LSM+ (linseed expeller meal, challenged). The intestinal micro-array technique is a promising tool to study the relationship between nutrition and feeding and gut tissue responses under defined conditions. 相似文献
10.
Effects of essential oil supplementation of a low‐energy diet on performance,intestinal morphology and microflora,immune properties and antioxidant activities in weaned pigs
下载免费PDF全文
![点击此处可从《Animal Science Journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Zhikai Zeng Xiao Xu Qiang Zhang Ping Li Panfeng Zhao Qingyun Li Jundi Liu XiangShu Piao 《Animal Science Journal》2015,86(3):279-285
A total of 144 weaned piglets were used to evaluate the effects of essential oil (EO) supplementation of a low‐energy diet on performance, apparent nutrient digestibility, small intestinal morphology, intestinal microflora, immune properties and antioxidant activities in weaned pigs. Pigs received a low‐energy diet (negative control, NC, digestible energy = 3250 kcal/kg), NC plus 0.025% EO or a positive control diet (PC, digestible energy = 3400 kcal/kg) for 28 days. Growth performance was similar between the EO group and PC group. However, EO supplementation increased (P < 0.05) average daily gain and the apparent digestibility of dry matter, crude protein and energy compared with pigs fed the NC diet. Greater (P < 0.05) villus height and lower (P < 0.05) counts of Escherichia coli and total anaerobes in the rectum in the EO group were observed compared with NC or PC groups. Pigs fed EO diet had higher (P < 0.05) concentrations of albumin, immunoglobulin A (IgA), IgG and total antioxidant capacity and lower fecal score than pigs fed the PC and NC diets. Above all, this study indicates that supplementation of EO to a low‐energy pig diet has beneficial results and obtains similar performance compared with normal energy (PC) diet. 相似文献
11.
The intestinal microbiota has gained increased attention from researchers within the swine industry due to its role in promoting intestinal maturation,immune system modulation,and consequently the enhancement of the health and growth performance of the host.This review aimed to provide updated scientific information on the interaction among intestinal microbiota,dietary components,and intestinal health of pigs.The small intestine is a key site to evaluate the interaction of the microbiota,diet,and host because it is the main site for digestion and absorption of nutrients and plays an important role within the immune system.The diet and its associated components such as feed additives are the main factors affecting the microbial composition and is central in stimulating a beneficial population of microbiota.The microbiotaehost interaction modulates the immune system,and,concurrently,the immune system helps to modulate the microbiota composition.The direct interaction between the microbiota and the host is an indication that the mucosa-associated microbiota can be more effective in evaluating its effect on health parameters.It was demonstrated that the mucosa-associated microbiota should be evaluated when analyzing the interaction among diets,microbiota,and health.In addition,supplementation of feed additives aimed to promote the intestinal health of pigs should consider their roles in the modulation of mucosa-associated microbiota as biomarkers to predict the response of growth performance to dietary interventions. 相似文献
12.
文章旨在研究日粮添加不同水平抗菌肽替代抗生素对断奶仔猪生长性能、养分消化率、肠道微生物含量及绒毛结构的影响。试验选择平均体重为(5.76±0.02)kg的21 d断奶的杜×长×大仔猪672头,根据个体大小随机分为4组,每组4个重复,每个重复42头。试验分为1~14 d和15~28 d两个阶段,对照组饲喂基础日粮+60 mg/kg盐霉素,抗菌肽组饲喂基础日粮+0、50或100 mg/kg抗菌肽。试验进行28 d。对照组较抗菌肽组显著提高了断奶仔猪28 d体重(P <0.05),1~14 d和1~28 d日增重(P <0.05),1~14 d、15~28 d、1~28 d采食量,显著降低了1~28 d料重比(P <0.05)。随着日粮抗菌肽添加水平的升高,28 d体重、1~14 d、15~28 d及1~28 d日增重显著升高(P <0.05)。对照组较抗菌肽组显著提高了断奶仔猪14和28 d干物质、14 d粗蛋白质表观消化系数(P <0.05)。对照组较抗菌肽组显著降低了14和28 d粪中大肠杆菌含量(P <0.05),且总厌氧菌、梭菌和大肠杆菌含量随抗菌肽添加水平的升高而显著降低(P <0.05);与抗菌肽组相比,对照组显著降低了回肠总厌氧菌含量(P <0.05)。饲喂对照组日粮的断奶仔猪较抗菌肽组显著降低了空肠隐窝深度(P <0.05),显著提高了空肠绒毛高度与隐窝深度的比值(P <0.05)。根据试验结果推断,日粮添加抗菌肽可以作为抗生素替代品,具有提高断奶仔猪生长性能、干物质和粗蛋白质的表观消化率、绒毛形态及降低粪中有害菌含量的作用。 相似文献
13.
14.
文章旨在研究日粮添加不同水平的纳米银对断奶仔猪生长性能、肠道形态及微生物菌群的影响。本研究共进行3个试验,试验1收集8头断奶后7 d仔猪的回肠内容物,在体外37℃条件下分别添加0、20、40和80μg/kg纳米银,孵育4 h。结果显示,随着纳米银添加水平的升高,回肠内容物大肠杆菌和乳酸杆菌的含量显著线性降低(P<0.05),但对乳酸杆菌比例无显著影响(P>0.05)。试验2分为3个组,每组10头21 d断奶的仔猪,日粮中分别添加0、20和40 mg/kg纳米银,结果发现随着纳米银添加水平的升高,断奶后2周仔猪的日增重表现为显著线性升高(P<0.05),同时回肠大肠杆菌含量有显著线性降低的趋势(P=0.07),显著降低了细菌总量和奇异菌属含量(P<0.05)。20 mg/kg纳米银组产气荚膜杆菌与梭菌比例最低(P<0.05)。试验3分为3组,每组选择10头21 d断奶仔猪,日粮中分别添加0、20和40 mg/kg纳米银,结果发现,日粮纳米银添加水平对仔猪断奶后前两周绒毛形态无显著影响(P>0.05),而隐窝深度有降低趋势(P=0.08)。20 mg/kg纳米银组仔猪在断奶前两周表现为最高(P<0.05),之后随着纳米银添加水平的升高在3~4周显著降低(P<0.05),料比显著升高(P<0.05)。日粮添加低剂量的纳米银可以改善断奶仔猪的采食量和日增重,适宜添加水平为20~40 mg/kg。 相似文献
15.
Hrvoje Valpoti? Gordan Mr?i? Branka Gr?kovi? Daniel ?poljari? Dubravko Kezi? Sini?a Sre?ec Mirjana Matau?i?-Pi?l Gordana Lackovi? Darko Capak Damir Miheli? Ksenija Vlahovi? Ivica Valpoti? Ahmed Pirki? Deny Andjelinovic Maja Popovi? 《Acta veterinaria Scandinavica》2013,55(1):54
Background
Because European-wide directives are restricting the non-clinical use of antibiotics as in-feed growth promotors in swine production, there is an intensive search for alternative strategies for control and prevention of losses among young pigs. With the growing knowledge of the porcine immune system and its endogenous modulation, it has been clearly established that exogenous immunomodulation using adjuvants and immune response modifiers (IRMs) represents an important prophylactic/therapeutic approach in the prevention/treatment of both stress- and microbial-induced disorders that accompaning weaning. However, it is essential to select a fully evaluated agent which may act either as a nonspecific IRM or synergistically as an adjuvant with vaccines. The synthetic macromolecules with a long history as adjuvant and IRM are nonionic block copolymers which consist of polyoxyethylene (POE) and polyoxypropylene (POP) molecules.Methods
The aim of this work was to evaluate the effectiveness of POE-POP given as a single peroral dose on productivity parameters such as body weight gain, feed intake and feed conversion ratio, and systemic and intestinal immune parameters by assessing the proportions of CD45+ lymphoid cells, CD4+ and CD8+ T cells, and CD21+ B cells in the peripheral blood as well as the number of CD45RA+ naive lymphoid cells residing in the ileal mucosa in weaned pigs during a follow-up study 5 weeks after the treatment.Results
Pigs treated with POE-POP had better feed intake (+ 14.57%), higher average body mass at the end of the experiment (20.91 kg vs. 17.61 kg), and higher body weight gain in relation to Day 0 (191.63% vs. 144.58%) as well as in relation to nontreated pigs (+ 18.74%), with a lower feed conversion ratio (− 30.26%) in comparison to the control pigs. A much lower diarrhea severity score (5 vs. 54) was recorded in pigs treated with POE-POP (− 90.74%) than in the control pigs. A higher average diarrhea severity (ADS) was recorded in the control pigs (1.54 vs. 0.14), whereas the treatmant group had much a lower ADS ratio (− 90.91%) after 35 days of the experiment. The pigs that were treated with POE-POP had an increased proportion of CD45+, CD4+ and CD8+ cells at Day 21 (at p < 0.05, p < 0.05 or p < 0.01, respectively), Day 28 (at p < 0.01, respectively) and Day 35 (at p < 0.01, p < 0.05 or p < 0.01, respectively) as well as of CD21+ cells at Day 28 (p < 0.05) and Day 35 of the experiment (p < 0.01). Also, these pigs had more numerous CD45RA+ cells in interfollicular (p < 0.05) and follicular areas (p < 0.01) of the ileal Peyer’s patches than did control pigs.Conclusion
This property of POE-POP to induce recruitment of circulating and intestinal immune cell subsets in weaned pigs may allow the use of IRM-active block copolymers as adjuvants for vaccines, particularly those orally delivered and targeted to the gut-associated lymphoid tissues that are well known to promote rather tolerogenic than protective immune responses. 相似文献16.
17.
Effects of feeding linseed and linseed expeller meal to newly weaned piglets on growth performance and gut health and function 总被引:1,自引:0,他引:1
The effects were evaluated of the inclusion of full fat linseed (125 g/kg) (LS) or linseed expeller meal (85 g/kg) (LSM) in diets for weaned piglets on growth performance and parameters of gut health and function. The diets were fed to groups of 12 post weaning single housed piglets. Three of the five treatments (Control (C)+, LS+, LSM+) were challenged with an enterotoxigenic strain of E. coli on day 6. Two treatments were not challenged (C− and LS−). The main response criteria were daily feed intake, body weight gain, faecal shedding of the E. coli, faecal consistency score, faecal nutrient digestibility and gut wall morphology and histology of the jejunal mucosa on day 18/19 of the study. Over the total experimental period (day 0–18) feed intake and body weight gain were highest in treatment C− and lowest in treatment LSM+ (P < 0.05). Feed conversion ratio did not differ between treatments over the total experimental period. Over day 10–12 of the study, the faecal digestibility of dry matter, ash and energy was higher for treatments C− and C+ compared to treatments LS−, LS+ and LSM+ (P < 0.05). There was no significant difference in the faecal shedding of E. coli between treatments C+, LS+ and LSM+. Intestinal mucosal histology and morphology were only slightly affected by the dietary treatments. It was concluded that the use of full fat linseed or linseed expeller meal did not show to be functional ingredients in diets for post-weaning piglet in terms of supporting gut health. 相似文献
18.
Yi GF Carroll JA Allee GL Gaines AM Kendall DC Usry JL Toride Y Izuru S 《Journal of animal science》2005,83(3):634-643
Forty weaned barrows (5.32 +/- 0.3 kg BW) at 17 +/- 2 d of age were used to investigate the effects of feeding glutamine and spray-dried plasma on the growth performance, small intestinal morphology, and immune responses of Escherichia coli K88-challenged pigs. Pigs were allotted to four treatments including: 1) nonchallenged control (NONC); 2) challenged control (CHAC); 3) 7% (as-fed basis) spray-dried plasma (SDP); and 4) 2% (as-fed basis) glutamine (GLN). On d 11 after weaning, all pigs were fitted with an indwelling jugular catheter. On d 12 after weaning, pigs in the CHAC, SDP, and GLN groups were orally challenged with skim milk E. coli K88 culture, whereas pigs in the NONC group were orally inoculated with sterilized skim milk. Rectal temperatures and fecal diarrheic scores were recorded and blood samples collected at 0 (baseline), 6, 12, 24, 36, and 48 h after the challenge for serum hormone and cytokine measurements. At 48 h postchallenge, all pigs were killed for evaluation of small intestinal morphology. There was no effect of feeding SDP or GLN on growth performance during the 11-d prechallenge period (P = 0.13). At 48 h after the challenge, CHAC pigs had decreased ADG (P = 0.08) and G:F (P = 0.07) compared with the NONC pigs; however, SDP and NONC pigs did not differ in G:F, and GLN and NONC pigs did not differ for ADG and G:F. At 6, 36, and 48 h after the challenge, CHAC, SDP, and GLN pigs had increased rectal temperature relative to the baseline (P = 0.09). At 12 and 36 h after the challenge, CHAC pigs had the highest incidence of diarrhea among treatments (P = 0.08). Serum IL-6 and ACTH were not affected by treatment or time after E. coli challenge (P = 0.11). In proximal, midjejunum, and ileum, CHAC pigs had greater villous atrophy and intestinal morphology disruption than NONC pigs (P < 0.01), whereas SDP and GLN pigs had mitigated villous atrophy and intestinal morphology impairment after E. coli challenge. Pigs in the SDP had the lowest GH at 12 h and the greatest GH at 36 h after the challenge among treatments (P = 0.08). Pigs in the NONC had the highest IGF-1 at 12 and 36 h postchallenge (P < 0.04). These results indicate that feeding glutamine has beneficial effects in alleviating growth depression of E. coli K88-challenged pigs, mainly via maintaining intestinal morphology and function, and/or possibly via modulating the somatotrophic axis. 相似文献
19.
W.R. Caine B.U. Metzler-Zebeli M. McFall B. Miller T.L. Ward R.N. Kirkwood R. Mosenthin 《Research in veterinary science》2009,86(3):453-462
Eighty male pigs from 20 litters were used to evaluate dietary addition of 250 mg/kg of Zn from zinc amino acid complex (ZnAA) to sows during the last trimester of gestation and gastric intubation of 40 mg Zn from soluble zinc methionine (ZnMet) to suckling pigs at birth and on day 7 and 14 (weaning) on small intestinal morphology, Zn status and bacterial translocation in early-weaned pigs. At weaning, pigs were challenged with an intramuscular injection of saline without or with 120 μg/kg BW of lipopolysaccharide (LPS; from Escherichia coli O26:B6) and were euthanized 24 h later prior to collection of intestinal lymph nodes and small intestinal sections. Zinc concentration in serum 7 days after birth and at weaning were higher in pigs from ZnAA-supplemented sows and those receiving gastric intubation with ZnMet (P = 0.05 and P < 0.0001, respectively). Post-weaning liver tissue concentrations for Zn (P < 0.0001) and Fe (P = 0.04) were higher and for Cu lower (P < 0.0001) in pigs intubated with ZnMet. Pigs from ZnAA-supplemented compared with control-fed sows tended (P < 0.1) to have increased villi height and villus:crypt ratio in the jejunum and higher (P = 0.1) goblet cell counts in the ileum. Goblet cell counts of ZnMet-intubated (P = 0.03) and LPS-challenged pigs (P = 0.05) were also higher in the jejunum. Supplementation of ZnAA to gestating sows increased (P = 0.04) E. coli colony forming unit counts in the small intestinal mesenteric lymph nodes of early-weaned pigs. In conclusion, dietary addition of ZnAA to gestating sows and gastric intubation of ZnMet improved Zn status of suckling pigs. 相似文献
20.
本研究旨在探讨日粮添加壳寡糖对断奶仔猪生长性能、营养物质消化率和小肠功能的影响,评估其作为断奶仔猪日粮中抗生素替代品的效果。试验选择21 d断奶的三元仔猪280头,随机分为5组,每组4个重复,每个重复14头猪,各组猪只分别饲喂在基础日粮中分别添加0、80、160、240 mg/kg壳寡糖和45 mg/kg盐霉素的日粮,试验分为1~28 d和29~56 d两个阶段,共进行8周。结果显示,日粮添加160 mg/kg壳寡糖显著提高回肠粗蛋白质、粗脂肪、灰分、钙和磷的表观消化率(P <0.05),显著提高小肠绒毛高度及绒毛高度与隐窝深度的比值(P <0.05),同时显著提高56 d十二指肠和空肠隐窝细胞增殖活力(P <0.05)。结论:日粮添加160 mg/kg壳寡糖可以通过提高回肠养分表观消化率、绒毛高度和肠上皮细胞的数量来促进消化吸收能力,进而提高断奶仔猪生长性能和健康状态,其作用与盐霉素的效果相当。 相似文献