The prevention of atrophic rhinitis of swine

In a pig breeding unit that for years had been infected with Atrophic Rhinitis, the weaned piglets were divided into four groups. Group 1 (10 weaned piglets) --Their mother was vaccinated with 2 ml Rhinipig i.m. 3 weeks prior to farrowing. --The piglets received 0.2 ml each of Pargenta 50 (= 10 mg Gentamycin) i.m. on the third, fifth and seventh days after birth. --The piglets were fed a food containing 10 ppm Gentamycin-base during the 6 weeks following their weaning. Group 2 (10 weaned piglets) --Their mother was vaccinated with 2 ml Rhinipig i.m. 3 weeks prior to farrowing. --The piglets received 0.2 ml each of Pargenta 50 (= 10 mg Gentamycin) i.m. on the third, fifth and seventh days after birth. Group 3 (10 weaned piglets) --Their mother was vaccinated with 2 ml Rhinipig i.m. 3 weeks prior to farrowing. Group 4 (10 weaned piglets, untreated, experimental control group) After 6 weeks of treatment, Group 1 showed significantly better food conversion and daily weight gain when compared to the other groups.     

猪传染性萎缩性鼻炎的诊断与防治

近年来 ,张掖地区某大型猪场发生以猪鼻甲骨萎缩 ,鼻部变形及生长迟缓等为特征的一种慢性疾病 ,造成巨大的经济损失。我们对该场病猪进行了临床诊断、病理剖检和微生物检查 ,最后确诊为支气管败血波氏杆菌引起的猪传染性萎缩性鼻炎。1　临床症状仔猪打喷嚏、流鼻涕、喷鼻息 ,有不同程度的卡他性鼻炎 ,产生不同量的浆液性或粘液性鼻分泌物 ,最早 1周龄 ,6～ 8周龄最显著。病猪表现不安 ,到处拱地、奔跑 ,以后病情逐渐加重 ,持续 3周以上开始发生鼻甲骨萎缩。病猪在整个病程中打喷嚏、流鼻涕、气喘 ,同时有不同量的浆液性、脓性分泌物流出。严…     

An experimental mouse model of progressive atrophic rhinitis of swine

Pasteurella multocida is responsible for a variety of diseases of veterinary importance, including the pig disease progressive atrophic rhinitis (PAR). The feasibility of using the mouse as an experimental model of PAR was evaluated. We experimentally infected the upper respiratory tract of immature mice with a pig isolate of P. multocida that produces the toxin responsible for causing the nasal lesions characteristic of PAR. We tracked the health status and weight gain of these mice for one month following infection, after which the mice were killed and the integrity of the nasal turbinates was examined. Mice infected with P. multocida appeared healthy throughout the study, although the growth rate of these mice was reduced significantly compared with non-infected control animals. Infected animals also demonstrated marked nasal atrophy analogous to that seen in naturally occurring PAR of swine, with shortening and thinning of the turbinate scrolls and inflammatory cell involvement. The mouse therefore provides a convenient model for the further investigation of PAR of swine.     

猪萎缩性鼻炎凝集反应抗原的制备及应用

为快速地诊断猪萎缩性鼻炎及监测其免疫状况,本试验在对支气管败血波氏杆菌保存菌种进行复苏和全面鉴定的基础上,制备了猪萎缩性鼻炎凝集反应抗原,经凝集反应试验表明,该抗原在PBS中不发生自凝,与猪传染性胸膜肺炎、猪喘气病和猪瘟的阳性血清均无凝集反应,而对猪萎缩性鼻炎标准阳性血清的凝集效价高达1∶10 240以上,具有较高的特异性和敏感性;对20份免疫母猪所产仔猪血清样本进行检测,检出率为95%.     

广东地区猪传染性萎缩性鼻炎流行病学调查

为了解广东地区猪传染性萎缩性鼻炎(AR)的流行情况,本研究采用细菌分离、鼻甲骨组织形态学测定(TPR值)等方法,对广东各区14个规模在500头母猪的养猪场随机抽样进行AR的流行病学调查。试验统计数据显示,调查的14个猪场均存在AR,平均发病率为58.58%,平均支气管败血波氏杆菌(Bb)感染率为46.74%;抽样猪场中猪的萎缩指数平均数为1.286,萎缩指数标准差为1.871。结果表明,AR在广东省广泛流行,Bb感染率高。